2001
1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies
Laden F, Collman G, Iwamoto K, Alberg A, Berkowitz G, Freudenheim J, Hankinson S, Helzlsouer K, Holford T, Huang H, Moysich K, Tessari J, Wolff M, Zheng T, Hunter D. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and Polychlorinated Biphenyls and Breast Cancer: Combined Analysis of Five U.S. Studies. Journal Of The National Cancer Institute 2001, 93: 768-775. PMID: 11353787, DOI: 10.1093/jnci/93.10.768.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskRisk factorsEffect modificationOdds ratioBreast cancer risk factorsElevated breast cancer riskAssess effect modificationBody mass indexCancer risk factorsConfidence intervalsPooled odds ratioPotential risk factorsPlasma/serum concentrationsAssociation of levelsLarge U.S. studiesRandom-effects modelCase patientsMass indexMiddle tertileFifth quintilePooled analysisControl subjectsSerum concentrations
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedBreastBreast NeoplasmsEnvironmental PollutantsFemaleHumansLogistic ModelsMiddle AgedPolychlorinated BiphenylsRiskConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionBreast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls
Zheng T, Holford TR, Tessari J, Mayne ST, Owens PH, Ward B, Carter D, Boyle P, Dubrow R, Archibeque-Engle S, Zahm SH. Breast Cancer Risk Associated with Congeners of Polychlorinated Biphenyls. American Journal Of Epidemiology 2000, 152: 50-58. PMID: 10901329, DOI: 10.1093/aje/152.1.50.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedBreast NeoplasmsCase-Control StudiesFemaleHumansMiddle AgedPolychlorinated BiphenylsRisk FactorsConceptsBreast cancer riskCancer riskCovariate-adjusted odds ratioBreast Cancer Risk AssociatedCase-control studyBreast cancer casesBreast adipose tissueMean tissue levelsCancer Risk AssociatedLowest tertileThird tertileBreast diseaseOdds ratioBreast cancerCancer casesConnecticut womenAdipose tissueFurther stratificationSignificant associationStudy participantsTissue levelsNonhormonal activitiesBody levelEnvironmental exposuresSpecific PCB congeners