2005
Association of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies
Grosso L, Triche E, Belanger K, Benowitz N, Holford T, Bracken M. Association of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies. Annals Of Epidemiology 2005, 15: 659-660. DOI: 10.1016/j.annepidem.2005.07.037.Peer-Reviewed Original ResearchPreterm deliveryQuartile changeCohort studyCord bloodRatio of paraxanthineProspective cohort studyMethodsProspective cohort studyUmbilical cord bloodSelf-reported caffeine consumptionLogistic regression modelsOne-unit increaseThird trimesterSerum caffeineIUGRUmbilical cordCaffeine exposureReproductive outcomesAssociation of caffeineCaffeine consumptionHealth outcomesCaffeine ratioImportant covariatesRiskOutcomesBlood
2003
Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk
Zheng T, Holford T, Zahm S, Owens P, Boyle P, Zhang Y, Zhang B, Wise J, Stephenson L, Ali-Osman F. Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk. British Journal Of Cancer 2003, 88: 58-62. PMID: 12556960, PMCID: PMC2376773, DOI: 10.1038/sj.bjc.6600708.Peer-Reviewed Original ResearchConceptsBreast cancer riskGSTT1 null genotypeCancer riskAlcohol consumptionGST genotypesBreast cancerPostmenopausal womenGenetic polymorphismsIncident breast cancer patientsGlutathione S-transferase M1Breast cancer patientsT1 genetic polymorphismsCase-control studyGSTT1 genetic polymorphismsGlutathione S-transferaseS-transferase M1Cancer patientsEffect modificationGSTM1 genotypeHigh riskNew Haven CountyYounger ageCancerWomenRisk
2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original ResearchRadiation exposure from diagnostic and therapeutic treatments and risk of breast cancer
Zheng T, Holford TR, Mayne ST, Luo J, Owens PH, Zhang B, Zhang W, Zhang Y. Radiation exposure from diagnostic and therapeutic treatments and risk of breast cancer. European Journal Of Cancer Prevention 2002, 11: 229-235. PMID: 12131656, DOI: 10.1097/00008469-200206000-00006.Peer-Reviewed Original ResearchConceptsBreast cancerTherapeutic radiation treatmentRadiation treatmentOdds ratioTherapeutic radiationSkin problemsBreast cancer risk factorsRadiation exposureCancer risk factorsBreast cancer riskCase-control studyDiagnostic X-ray exposurePostmenopausal womenRisk factorsCancer riskHigh riskYounger ageTherapeutic treatmentCancerDiagnostic X-raysPerson interviewsTreatmentX-ray exposureRiskStructured questionnaireA case-control study of occupation and breast-cancer risk in Connecticut.
Zheng T, Holford T, Taylor Mayne S, Luo J, Hansen Owens P, Hoar Zahm S, Zhang B, Zhang Y, Zhang W, Jiang Y, Boyle P. A case-control study of occupation and breast-cancer risk in Connecticut. Journal Of Cancer Epidemiology And Prevention 2002, 7: 3-11. PMID: 12369604, DOI: 10.1080/14766650252962621.Peer-Reviewed Original Research
2001
Lactation and breast cancer risk: a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Zhang Y, Zhang B, Boyle P, Zahm S. Lactation and breast cancer risk: a case–control study in Connecticut. British Journal Of Cancer 2001, 84: 1472-1476. PMID: 11384096, PMCID: PMC2363665, DOI: 10.1054/bjoc.2001.1793.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancerCancer riskIncident breast cancer casesMajor risk factorCase-control studyBreast cancer casesRisk reductionMenopausal statusParous womenPostmenopausal womenInverse associationRisk factorsCancer casesStudy interviewersFurther stratificationFirst childWomenStructured questionnaireLifetime durationCancerRiskLactationChildrenBreastfeeding
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionExposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk
Zheng T, Holford T, Mayne S, Owens P, Zhang B, Boyle P, Carter D, Ward B, Zhang Y, Zahm S. Exposure to Electromagnetic Fields from Use of Electric Blankets and Other In-Home Electrical Appliances and Breast Cancer Risk. American Journal Of Epidemiology 2000, 151: 1103-1111. PMID: 10873135, DOI: 10.1093/oxfordjournals.aje.a010154.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskOdds ratioAge frequency-matched controlsIncident breast cancer patientsElectric blanketFrequency-matched controlsAdjusted odds ratioBreast cancer patientsEstrogen receptor statusFemale breast cancerCase-control studyDuration of useReceptor statusCancer patientsNever usersBreast cancerStudy interviewersRegular useLifetime useRiskStructured questionnaireExposureTotalOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1998
Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds
Belanger K, Leaderer B, Hellenbrand K, Holford T, McSharry J, Power M, Bracken M. Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds. Epidemiology 1998, 9: 36-42. PMID: 9430266, DOI: 10.1097/00001648-199801000-00009.Peer-Reviewed Original ResearchConceptsElectric blanket useSpontaneous abortionPregnancy lossBlanket useEarly pregnancy lossHeated water bedsTime of conceptionMonth of conceptionWire code categoriesWeeks' gestationProspective studyEarly pregnancyUnadjusted analysesBed useGreater riskPregnancyAbortionDose responseWomenRiskElectric bedElectric blanketExposureSlight increaseGestationSeizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure
Berg A, Darefsky A, Holford T, Shinnar S. Seizures with Fever After Unprovoked Seizures: An Analysis in Children Followed from the Time of a First Febrile Seizure. Epilepsia 1998, 39: 77-80. PMID: 9578016, DOI: 10.1111/j.1528-1157.1998.tb01277.x.Peer-Reviewed Original ResearchConceptsFirst febrile seizureFebrile seizuresUnprovoked seizuresFurther seizuresFirst unprovoked seizureRecurrent febrile seizuresCox regression modelBenign febrile seizuresInfluence recurrenceTime-dependent covariatesProspective cohortSecond seizureTreatment decisionsFeverSeizuresSubstantial riskRate ratioYoung childrenChildrenOnsetRegression modelsSmall proportionRiskPredictorsRecurrence
1997
Mouthwash use and dentures in relation to oral epithelial dysplasia
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Kerpel S, Freedman P, Mayne S. Mouthwash use and dentures in relation to oral epithelial dysplasia. Oral Oncology 1997, 33: 338-343. PMID: 9415333, DOI: 10.1016/s1368-8375(97)00019-5.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaMouthwash useEpithelial dysplasiaDenture useOdds ratioYears of dentureOral Pathology LaboratoryCase-control studyConditional logistic regressionCase-control pairsOED casesAppointment datePotential associationLogistic regressionTelephone interviewsExposure informationPathology laboratoryConfidence intervalsDysplasiaDenturesMouthwashRiskSmokingYearsSurgeonsRisk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study
Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997, 33: 82-85. PMID: 9231164, DOI: 10.1016/s0964-1955(96)00056-5.Peer-Reviewed Original ResearchConceptsTongue cancerCase-control studyTobacco smokingAlcohol drinkingRisk factorsCurrent smokersCigarette equivalentsQuitting smokingEffect modificationTobacco consumptionSmokingAlcohol consumptionNumber of casesSignificant associationCancerYoung populationRiskRecent studiesDrinkingDaysSmokersYearsStudyDiseaseWeeks
1995
EXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS
Bracken M, Belanger K, Hellenbrand K, Dlugosz L, Holford T, McSharry J, Addesso K, Leaderer B. EXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS. Epidemiology 1995, 6: 263-270. PMID: 7619934, DOI: 10.1097/00001648-199505000-00013.Peer-Reviewed Original ResearchConceptsFetal growth retardationGrowth retardationBed useIntrauterine growth retardationVideo display terminal useDose-response relationPersonal monitorsEMF exposureTime-weighted analysisMonitoring of exposureThird trimesterProspective studyFetal growthWire codesHome measurementsReproductive outcomesHuman studiesPregnancyStudy designVideo display terminalsExposure measuresHours of useMeaningful increaseRiskExposure
1986
Risk of Late First and Second Trimester Miscarriage After Induced Abortion
Bracken M, Bryce-Buchanan C, Srisuphan W, Holford T, Silten R. Risk of Late First and Second Trimester Miscarriage After Induced Abortion. American Journal Of Perinatology 1986, 3: 84-91. PMID: 3964388, DOI: 10.1055/s-2007-999839.Peer-Reviewed Original ResearchConceptsFirst prenatal visitSecond trimester miscarriagePrivate obstetric practicesLate miscarriagePrenatal visitFirst pregnancySecond pregnancySecond trimesterSubsequent miscarriageTrimester miscarriagePregnancy historyObstetric practiceInduced abortionMiscarriagePregnancyWomenAbortionRiskLate FirstTrimesterCohortVisitsLOW BIRTH WEIGHT IN PREGNANCIES FOLLOWING INDUCED ABORTION: NO EVIDENCE FOR AN ASSOCIATION1
BRACKEN M, HELLENBRAND K, HOLFORD T, BRYCE-BUCHANAN C. LOW BIRTH WEIGHT IN PREGNANCIES FOLLOWING INDUCED ABORTION: NO EVIDENCE FOR AN ASSOCIATION1. American Journal Of Epidemiology 1986, 123: 604-613. PMID: 3953539, DOI: 10.1093/oxfordjournals.aje.a114280.Peer-Reviewed Original ResearchConceptsLow birth weightMean birth weightFirst pregnancyBirth weightSecond pregnancyInduced abortionLow birth weight newbornsLow birth weight rateAntecedent pregnancyWeight newbornsSubsequent pregnancyAbortion complicationsVacuum aspirationPrior abortionPregnancyAbortionWeight rateSimilar ratesMonthsWomenDeliveryRiskCurettageComplicationsGestation
1985
Menarcheal age and habitual miscarriage: evidence for an association
Bracken M, Bryce-Buchanan C, Stilten R, Holford T. Menarcheal age and habitual miscarriage: evidence for an association. Annals Of Human Biology 1985, 12: 525-531. PMID: 4091507, DOI: 10.1080/03014468500008101.Peer-Reviewed Original Research
1984
Acute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking
KELSEY J, GITHENS P, O'CONNER T, WEIL U, CALOGERO J, HOLFORD T, WHITE A, WALTER S, OSTFELD A, SOUTHWICK W. Acute Prolapsed Lumbar Intervertebral Disc An Epidemiologic Study with Special Reference to Driving Automobiles and Cigarette Smoking. Spine 1984, 9: 608-613. PMID: 6495031, DOI: 10.1097/00007632-198409000-00012.Peer-Reviewed Original ResearchConceptsCigarette smokingAverage riskNumber of pregnanciesPossible etiologic significanceCase-control studyEpidemiologic case-control studyRatio of menLumbar intervertebral discsNonoccupational factorsFemale ratioRisk factorsEpidemiologic studiesHigh riskSurgical casesEtiologic significanceNumber of childrenLumbar discIntervertebral discHigh heelsSmokingRiskNumber of hoursPast yearPregnancySurgeryAn epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc
Kelsey J, Githens P, White A, Holford T, Walter S, O'Connor T, Ostfeld A, Weil U, Southwick W, Calogero J. An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc. Journal Of Orthopaedic Research® 1984, 2: 61-66. PMID: 6491800, DOI: 10.1002/jor.1100020110.Peer-Reviewed Original Research
1983
Physical activity and the risk of spontaneous preterm delivery.
Berkowitz G, Kelsey J, Holford T, Berkowitz R. Physical activity and the risk of spontaneous preterm delivery. The Journal Of Reproductive Medicine 1983, 28: 581-8. PMID: 6631844.Peer-Reviewed Original ResearchConceptsPreterm deliveryPhysical activityLeisure-time physical activityYale-New Haven HospitalSingleton preterm infantsSingleton term infantsSpontaneous preterm deliveryPossible risk factorsModerate physical activityCase-control studyEpidemiologic case-control studyPhysical fitness exercisesPreterm infantsTerm infantsRisk factorsStudy groupPregnancyInfantsRiskFitness exercisesDeliveryMothersChild careQuestionnaire responsesHospital