2024
Cigarette smoking focus: A modeling approach for estimating the impact of health programs
Holford T. Cigarette smoking focus: A modeling approach for estimating the impact of health programs. Open Access Government 2024, 43: 82-83. DOI: 10.56367/oag-043-11502.Peer-Reviewed Original Research
2020
Modeling factors affecting age, period and cohort trends
Holford T. Modeling factors affecting age, period and cohort trends. 2020, 117-141. DOI: 10.4324/9780429056819-7.Peer-Reviewed Original ResearchAnalytical epidemiological studiesUnderstanding of etiologyCigarette smokingLung cancerEtiology of diseaseEpidemiological studiesCarcinogenesis modelDisease trendsCohort scaleCohort frameworkHealth careDiseaseExposure dataPopulation ratesCohort modelCohort trendsSmokingAgeEtiologyU.S. malesTemporal trendsEarly stepsCancerPeriodCare
2018
Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach.
Jeon J, Holford TR, Levy DT, Feuer EJ, Cao P, Tam J, Clarke L, Clarke J, Kong CY, Meza R. Smoking and Lung Cancer Mortality in the United States From 2015 to 2065: A Comparative Modeling Approach. Annals Of Internal Medicine 2018, 169: 684-693. PMID: 30304504, PMCID: PMC6242740, DOI: 10.7326/m18-1250.Peer-Reviewed Original ResearchConceptsLung cancer mortalityTobacco control effortsCancer mortalityLung cancer ratesLung cancerCancer ratesLung cancer burdenLung cancer deathsLung cancer screeningSmoking-related diseasesU.S. populationNational Cancer InstituteLonger life expectancyCancer burdenSmoking patternsCancer deathCessation effortsCancer screeningTobacco useCancer InstituteSmokingAdditional preventionNatural historyMortalityCancer
2015
Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate
Oh C, Holford TR. Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate. Statistics In Medicine 2015, 34: 1953-1964. PMID: 25715831, PMCID: PMC4980760, DOI: 10.1002/sim.6464.Peer-Reviewed Original ResearchConceptsCancer incidence ratesEstimates of incidenceHealth care planningCancer deathLung cancerCancer prevalenceCancer incidenceIncidence rateHealthy subjectsCare planningSurvival informationMortality statisticsCancerIncidence casesIncidenceAge periodDeathSubjectsCompartment modelCohortMortalityPrevalence
2012
Chapter 14: Comparing the Adequacy of Carcinogenesis Models in Estimating U.S. Population Rates for Lung Cancer Mortality
Holford TR, Levy DT. Chapter 14: Comparing the Adequacy of Carcinogenesis Models in Estimating U.S. Population Rates for Lung Cancer Mortality. Risk Analysis 2012, 32: s179-s189. PMID: 22882888, PMCID: PMC3478769, DOI: 10.1111/j.1539-6924.2011.01734.x.Peer-Reviewed Original ResearchConceptsLung cancer mortalityCancer mortalityCarcinogenesis modelLung cancer mortality ratesU.S. population ratesEffect of smokingCancer Prevention StudyCancer mortality ratesPopulation ratesTwo-stage clonal expansion modelEffect of ageSmoking trendsLung cancerPrevention StudyEstimates of riskMortality rateClonal expansionClonal expansion modelCohort modelSmokingIndividual cohortsCohortMortalityU.S. malesTemporal trendsImpact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000
Moolgavkar SH, Holford TR, Levy DT, Kong CY, Foy M, Clarke L, Jeon J, Hazelton WD, Meza R, Schultz F, McCarthy W, Boer R, Gorlova O, Gazelle GS, Kimmel M, McMahon PM, de Koning HJ, Feuer EJ. Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000. Journal Of The National Cancer Institute 2012, 104: 541-548. PMID: 22423009, PMCID: PMC3317881, DOI: 10.1093/jnci/djs136.Peer-Reviewed Original ResearchConceptsLung cancer deathsLung cancer mortalityCancer deathSmoking behaviorCancer mortalityMajor public health problemTobacco controlPublic health problemTobacco control strategiesNumber of deathsSmoking historyTobacco smokingLung cancerGroups of investigatorsBirth cohortHealth problemsFirst reportSmokingMortalityDeathUnited StatesWomenMenCohortCancer
1996
Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Mayne S, Liu W, Flannery J, Boyle P. Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 68: 172-176. PMID: 8900423, DOI: 10.1002/(sici)1097-0215(19961009)68:2<172::aid-ijc5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsUrinary bladder cancerMajor risk factorBladder cancerRisk factorsIncidence rateBirth-cohort patternSmoking-related cancersAnalytical epidemiologic studiesTime trendsTobacco smokingCigarette smokingLung cancerOccupational exposureEpidemiologic studiesCancerMarked increaseSmokingCohort effectsMalesRecent studiesCurrent studyFemalesIncidenceStudyConnecticutSecond solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation.
Salloum E, Doria R, Schubert W, Zelterman D, Holford T, Roberts K, Farber L, Kiehl R, Cardinale J, Cooper D. Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation. Journal Of Clinical Oncology 1996, 14: 2435-43. PMID: 8823321, DOI: 10.1200/jco.1996.14.9.2435.Peer-Reviewed Original ResearchConceptsOverall relative riskHodgkin's diseaseRT groupRelative riskSolid tumorsCMT groupRadiation therapyLung cancerBreast cancerEarly-stage Hodgkin's diseaseFull-dose radiation therapyInvolved-field radiationSecond solid tumorsConnecticut Tumor RegistryEarly-stage diseaseLong-term survivorsDifferent therapeutic approachesCases of lungLow-dose radiationSignificant increaseActuarial incidenceMedian followSalvage chemotherapyAdvanced diseaseDurable remissions
1994
Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989
Zheng T, Holford T, Boyle P, Chen Y, Ward B, Flannery J, Mayne S. Time trend and the age‐period‐cohort effect on the incidence of histologic types of lung cancer in connecticut, 1960‐1989. Cancer 1994, 74: 1556-1567. PMID: 8062189, DOI: 10.1002/1097-0142(19940901)74:5<1556::aid-cncr2820740511>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma, Bronchiolo-AlveolarAdultAge FactorsAgedAged, 80 and overCarcinomaCarcinoma, Small CellCarcinoma, Squamous CellCohort EffectCohort StudiesConnecticutFemaleHumansIncidenceLung NeoplasmsMaleMiddle AgedModels, StatisticalRegistriesSex FactorsSmokingTime FactorsConceptsAge-adjusted incidence ratesMajor histologic typesOverall age-adjusted incidence rateAge-specific incidence ratesHistologic typeLung cancer incidenceLung cancerIncidence rateBirth cohortRecent birth cohortsIncidence patternsObserved time trendsCell carcinomaCancer incidenceTime trendsConnecticut Tumor RegistryIncidence of adenocarcinomaSmall cell carcinomaSquamous cell carcinomaLung cancer casesRecent epidemiologic studiesDifferent histologic typesDifferent incidence patternsObserved incidence patternsTumor Registry