2000
Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
Bracken M, Aldrich E, Herr D, Hitchon P, Holford T, Marshall L, Nockels R, Pascale V, Shepard M, Sonntag V, Winn H, Young W. Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury. Journal Of Trauma And Acute Care Surgery 2000, 48: 558-561. PMID: 10744306, DOI: 10.1097/00005373-200003000-00036.Commentaries, Editorials and LettersConceptsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyClinical measurementsHigh-dose methylprednisoloneSecondary neuronal damageSpinal cord injuryRisk benefitNeuronal damageFunctional recoverySafety profileCord injuryPharmacologic agentsSpinal injuryInjury studiesInnovative therapiesTrialsStatistical analysisInjuryMulticenterMethylprednisoloneSeries of trialsTherapyPrevention
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareAdministration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury
BRACKEN M, SHEPARD M, HOLFORD T, LEO-SUMMERS L, ALDRICH E, FAZL M, FEHLINGS M, HERR D, HITCHON P, MARSHALL L, NOCKELS R, PASCALE V, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H, YOUNG W. Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury. Survey Of Anesthesiology 1998, 42: 197. DOI: 10.1097/00132586-199808000-00011.Peer-Reviewed Original Research
1996
MASCIS Evaluation of Open Field Locomotor Scores: Effects of Experience and Teamwork on Reliability
Basso D, Beattie M, Bresnahan J, Anderson D, Faden A, Gruner J, Holford T, Hsu C, Noble L, Nockels R, Perot P, Salzman S, Young W. MASCIS Evaluation of Open Field Locomotor Scores: Effects of Experience and Teamwork on Reliability. Journal Of Neurotrauma 1996, 13: 343-359. PMID: 8863191, DOI: 10.1089/neu.1996.13.343.Peer-Reviewed Original ResearchConceptsMulticenter Animal Spinal Cord Injury StudySpinal cord injuryBBB scoresCord injuryExperienced teamOpen field locomotor scoreSpinal Cord Injury StudyOpen field locomotor scaleSpinal-injured ratsMean scoreMotor recoveryLocomotor scoresLocomotor scaleInjury studiesHindlimb movementsToe clearanceReliability of scoringRatsCohortTrunk positionScoresSequential sessionsInjuryTeam scoresHigh reliability coefficient
1993
Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2.
Bracken M, Holford T. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. Journal Of Neurosurgery 1993, 79: 500-7. PMID: 8410217, DOI: 10.3171/jns.1993.79.4.0500.Peer-Reviewed Original ResearchConceptsNational Acute Spinal Cord Injury StudyNeurological recoveryIncomplete injuriesNeurological functionNaloxone administrationClinical managementAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneLong spinal tractsHours of injuryUltimate therapeutic goalInjury levelConsiderable clinical significanceNarrow treatment windowMethylprednisolone treatmentSpinal tractClinical significanceSegmental functionInjury studiesTherapeutic goalsTreatment windowMethylprednisoloneHigh dosesInjury
1992
A model for estimating level and net severity of spinal cord injuries
Holford T, Bracken M. A model for estimating level and net severity of spinal cord injuries. Statistics In Medicine 1992, 11: 1171-1186. PMID: 1509218, DOI: 10.1002/sim.4780110904.Peer-Reviewed Case Reports and Technical NotesConceptsSpinal cord injuryCord injuryNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyDetailed neurological assessmentNeurologic functionNeurological assessmentMotor assessmentInjury studiesOverall severityInjurySeverityScoresLevelsEpidemiology
1991
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
BRACKEN M, SHEPARD M, COLLINS W, HOLFORD T, YOUNG W, BASKIN D, EISENBERG H, FLAMM E, LEOSUMMERS L, MAROON J, MARSHALL L, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. Survey Of Anesthesiology 1991, 35: 50. DOI: 10.1097/00132586-199102000-00048.Peer-Reviewed Original Research
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose