2020
Modeling factors affecting age, period and cohort trends
Holford T. Modeling factors affecting age, period and cohort trends. 2020, 117-141. DOI: 10.4324/9780429056819-7.Peer-Reviewed Original ResearchAnalytical epidemiological studiesUnderstanding of etiologyCigarette smokingLung cancerEtiology of diseaseEpidemiological studiesCarcinogenesis modelDisease trendsCohort scaleCohort frameworkHealth careDiseaseExposure dataPopulation ratesCohort modelCohort trendsSmokingAgeEtiologyU.S. malesTemporal trendsEarly stepsCancerPeriodCare
2002
Associations between Exposure and Disease
Holford T. Associations between Exposure and Disease. 2002, 3-14. DOI: 10.1093/acprof:oso/9780195124408.003.0001.Peer-Reviewed Original ResearchAnalysis of Proportions
Holford T. Analysis of Proportions. 2002, 39-80. DOI: 10.1093/acprof:oso/9780195124408.003.0003.Chapters
1997
The increase of Hodgkin's disease incidence among young adults
Chen Y, Zheng T, Chou M, Boyle P, Holford T. The increase of Hodgkin's disease incidence among young adults. Cancer 1997, 79: 2209-2218. PMID: 9179069, DOI: 10.1002/(sici)1097-0142(19970601)79:11<2209::aid-cncr20>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsHodgkin's disease incidenceHodgkin's diseaseRisk factorsVirus infectionYoung adultsEpstein-Barr virus infectionHuman immunodeficiency virus (HIV) infectionConnecticut Tumor RegistryImmunodeficiency virus infectionAnalytical epidemiologic studiesMajor risk factorIncidence rate changesAdults ages 20Young adults ages 20Tumor RegistryHistologic typeDisease incidenceCohort analysisEpidemiologic studiesAge 20Cohort patternsCohort phenomenonIncidenceDiseaseYoung femalesRisk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study
Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997, 33: 82-85. PMID: 9231164, DOI: 10.1016/s0964-1955(96)00056-5.Peer-Reviewed Original ResearchConceptsTongue cancerCase-control studyTobacco smokingAlcohol drinkingRisk factorsCurrent smokersCigarette equivalentsQuitting smokingEffect modificationTobacco consumptionSmokingAlcohol consumptionNumber of casesSignificant associationCancerYoung populationRiskRecent studiesDrinkingDaysSmokersYearsStudyDiseaseWeeks
1995
Second solid malignancies after combined modality therapy for Hodgkin's disease.
Doria R, Holford T, Farber L, Prosnitz L, Cooper D. Second solid malignancies after combined modality therapy for Hodgkin's disease. Journal Of Clinical Oncology 1995, 13: 2016-22. PMID: 7636543, DOI: 10.1200/jco.1995.13.8.2016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceLymphoma, Non-HodgkinMaleMiddle AgedNeoplasms, Second PrimaryPoisson DistributionRadiation InjuriesRadiotherapyRadiotherapy DosageRecurrenceRemission InductionRisk FactorsConceptsSecond solid malignanciesActuarial incidenceRelative riskHodgkin's diseaseSolid tumorsGroup BRecurrent diseaseSolid malignanciesGroup AUntreated advanced Hodgkin's diseaseAdvanced Hodgkin's diseaseOverall relative riskLow-dose radiationSignificant increaseAdvanced diseaseUntreated patientsModality therapyHodgkin's lymphomaPatientsDiseaseCarcinogenic effectsChemotherapyLymphomaMalignancyCMT
1990
A Longitudinal Study Comparing Growth in Diabetic Pregnancies with Growth in Normal Gestations
REECE E, SMIKLE C, O'CONNOR T, HOLFORD T, NELSON-ROBINSON L, DEGENNARO N, HOBBINS J. A Longitudinal Study Comparing Growth in Diabetic Pregnancies with Growth in Normal Gestations. Obstetrical & Gynecological Survey 1990, 45: 160-164. PMID: 2190130, DOI: 10.1097/00006254-199003000-00003.Peer-Reviewed Original ResearchConceptsFetal growthDiabetic womenThird trimesterVascular diseaseMetabolic controlInsulin-dependent diabetic womenFetal growth accelerationStringent glucose controlNormal glycemic levelsPatients' metabolic controlDiabetic pregnanciesDiabetes mellitusGlycemic controlNormal pregnancyGlucose controlSecond trimesterSonographic evaluationGlycemic levelsNormal gestationGlycemic conditionsTrimesterUsual monitoringPregnancyRegression analysisDisease
1987
Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time
Peduzzi P, Holford T, Detre K, Chan Y. Comparison of the logistic and Cox regression models when outcome is determined in all patients after a fixed period of time. Journal Of Clinical Epidemiology 1987, 40: 761-767. PMID: 3597677, DOI: 10.1016/0021-9681(87)90127-5.Peer-Reviewed Original Research
1985
AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA
PASTIDES H, KELSEY J, HOLFORD T, LIVOLSI V. AN EPIDEMIOLOGIC STUDY OF FIBROCYSTIC BREAST DISEASE WITH REFERENCE TO DUCTAL EPITHELIAL ATYPIA. American Journal Of Epidemiology 1985, 121: 440-447. PMID: 4014134, DOI: 10.1093/oxfordjournals.aje.a114016.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseDuctal epithelial atypiaCase-control studyBreast diseaseDuctal atypiaEpithelial atypiaMinimal atypiaBreast cancerFirst-degree female relativesBreast biopsy specimensRecent checkupSurgical menopauseEpidemiologic characteristicsFirst pregnancyBiopsy specimensRisk factorsEpidemiologic studiesAtypiaCheckupAtypia scoreFrequent checkupsBreast lesionsDiseaseFemale relativesOnly variableESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1
BERKOWITZ G, KELSEY J, HOLFORD T, LIVOLSI V, MERINO M, BECK G, ORT S, O'CONNOR T, WHITE C. ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1. American Journal Of Epidemiology 1985, 121: 238-245. PMID: 4014118, DOI: 10.1093/oxfordjournals.aje.a113994.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseReplacement therapyPostmenopausal womenHospital-based case-control studyMedical care utilizationPossible risk factorsCase-control studyDuration of useOdds of diseasePostmenopausal women1Care utilizationMenopausal estrogensExcess oddsRisk factorsSurgical conditionsTherapyDiseasePositive associationMore yearsWomenOddsAssociationEstrogen
1984
Exogenous hormone use and fibrocystic breast disease by histopathologic component
Berkowitz G, Kelsey J, Livolsi V, Merino M, Holford T, Hildreth N, Ort S, O'Connor T, White C. Exogenous hormone use and fibrocystic breast disease by histopathologic component. International Journal Of Cancer 1984, 34: 443-449. PMID: 6490201, DOI: 10.1002/ijc.2910340403.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseEstrogen replacement therapyBreast diseaseGross cystsReplacement therapyHospital-based case-control studyExogenous hormone useOral contraceptive usePost-menopausal womenCase-control studyPostmenopausal womenPremenopausal womenHormone useOral contraceptivesEpithelial atypiaControl womenPapillary hyperplasiaBiopsy specimensFibrocystic lesionsSurgical conditionsContraceptive useHistopathologic componentsWomenIncreased occurrenceDiseaseORAL CONTRACEPTIVE USE AND FIBROCYSTIC BREAST DISEASE AMONG PRE- AND POSTMENOPAUSAL WOMEN1
BERKOWITZ G, KELSEY J, LIVOLSI V, HOLFORD T, MERINO M, ORT S, O'CONNOR T, GOLDENBERG I, WHITE C. ORAL CONTRACEPTIVE USE AND FIBROCYSTIC BREAST DISEASE AMONG PRE- AND POSTMENOPAUSAL WOMEN1. American Journal Of Epidemiology 1984, 120: 87-96. PMID: 6741927, DOI: 10.1093/oxfordjournals.aje.a113878.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseOral contraceptive useBreast diseaseOral contraceptivesContraceptive useHospital-based case-control studyOral contraceptive exposureGeneral surgical serviceCase-control studyLong-term useContraceptive exposurePostmenopausal women1Postmenopausal womenPremenopausal womenCystic diseaseStudy groupSurgical servicesDecreased frequencyPast usersDiseaseIncreased occurrenceWomenContraceptivesNegative associationAssociation
1983
Oral Contraceptive Use and Fibrocystic Breast Disease With Special Reference to Its Histopathology23
Pastides H, Kelsey J, LiVolsi V, Holford T, Fischer D, Goldenberg I. Oral Contraceptive Use and Fibrocystic Breast Disease With Special Reference to Its Histopathology23. Journal Of The National Cancer Institute 1983, 71: 5-9. PMID: 6575209, DOI: 10.1093/jnci/71.1.5.Peer-Reviewed Original ResearchConceptsOral contraceptive useFibrocystic breast diseaseOral contraceptivesContraceptive useBiopsy specimensBreast diseaseHospital-based case-control studyCase-control studyHigh atypiaEpithelial atypiaGross cystsHistopathologic characteristicsFibrocystic diseaseAtypiaContraceptivesDiseaseMicroscopic cystsCystsNew HavenSimilar patternPapillomatosisHistopathologySpecial referenceCasesControl
1979
Fibroadenoma in oral contraceptive users. A histopathologic evaluation of epithelial atypia
Livolsi V, Stadel B, Kelsey J, Holford T. Fibroadenoma in oral contraceptive users. A histopathologic evaluation of epithelial atypia. Cancer 1979, 44: 1778-1781. PMID: 498048, DOI: 10.1002/1097-0142(197911)44:5<1778::aid-cncr2820440535>3.0.co;2-y.Peer-Reviewed Original ResearchConceptsEpithelial atypiaLong-term usersOral contraceptivesOral contraceptive useOral contraceptive usersFibrocystic diseaseHistopathologic evaluationBreast diseaseContraceptive usersCytologic atypiaContraceptive useEpithelial componentAtypiaEpidemiological investigationsFibroadenomaDiseaseContraceptives
1978
Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia
Livolsi V, Stadel B, Kelsey J, Holford T, White C. Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia. New England Journal Of Medicine 1978, 299: 381-385. PMID: 566853, DOI: 10.1056/nejm197808242990803.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseOral contraceptivesLong-term usersBreast cancerEpithelial atypiaFibrocystic diseaseBreast diseaseOral contraceptive usersLong-term usePremenopausal womenHistopathological evaluationHistologic standpointCystic diseasePremalignant formsEpidemiological studiesDiseaseContraceptivesAtypiaCancerWomenSignificant differencesNontakersIncidenceORAL CONTRACEPTIVES AND BREAST DISEASE
KELSEY J, HOLFORD T, WHITE C, MAYER E, KILTY S, ACHESON R. ORAL CONTRACEPTIVES AND BREAST DISEASE. American Journal Of Epidemiology 1978, 107: 236-244. PMID: 629261, DOI: 10.1093/oxfordjournals.aje.a112530.Peer-Reviewed Original ResearchConceptsBenign breast diseaseOral contraceptivesBreast diseaseSequential oral contraceptivesCombination oral contraceptivesAge group 20Case-control studyCorpus uteriRelative riskBreast cancerGroup 20ContraceptivesNumber of casesAge groupsSignificant associationCancerDiseaseLarge hospitalsWomenRiskHospitalUterusBreast