2024
Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHIV InfectionsHumansMass ScreeningPredictive Value of TestsSouth AfricaZambiaConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2020
Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials
Brault MA, Spiegelman D, Abdool Karim SS, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports 2020, 17: 249-258. PMID: 32297219, PMCID: PMC7260110, DOI: 10.1007/s11904-020-00492-4.Peer-Reviewed Original Research
2019
Interventions to improve the HIV continuum of care in China
Zhang X, Wang N, Vermund SH, Zou H, Li X, Zhang F, Qian HZ. Interventions to improve the HIV continuum of care in China. Current HIV/AIDS Reports 2019, 16: 448-457. PMID: 31776975, PMCID: PMC10767704, DOI: 10.1007/s11904-019-00469-y.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV continuumHIV epidemicPublic health intervention programsFree ART programHIV sexual transmissionHIV testing campaignsFormer plasma donorsPurpose of ReviewToHealth intervention programsTwo-thirdsViral suppressionHeterosexual transmissionPediatric mortalitySexual transmissionRisk groupsMore infectionsPlasma donorsRecent FindingsTheIntervention programsYoung menCareHIVHeterosexual menLower ratesTreatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaEffect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherenceSuboptimal Recent and Regular HIV Testing Among Black Men Who Have Sex With Men in the United States: Implications From a Meta-Analysis.
Liu Y, Silenzio VMB, Nash R, Luther P, Bauermeister J, Vermund SH, Zhang C. Suboptimal Recent and Regular HIV Testing Among Black Men Who Have Sex With Men in the United States: Implications From a Meta-Analysis. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 81: 125-133. PMID: 30844996, PMCID: PMC6956840, DOI: 10.1097/qai.0000000000002013.Peer-Reviewed Original ResearchConceptsHIV testing prevalenceRegular HIV testingTesting prevalenceHIV testingDerSimonian-Laird random-effects modelContinuum of HIVHIV testing effortsHIV testing patternsFrequent HIV testingIllicit drug useRandom-effects modelMeta-regression analysisBlack menWeb of ScienceLow annual incomeEgger's testReceptive sexPRISMA guidelinesFunnel plotAlcohol consumptionDrug useIndependent investigatorsMeta-AnalysisPublication biasYounger age
2018
Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis
Zhang X, Yu Y, Yang H, Xu H, Vermund SH, Liu K. Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis. Medical Science Monitor 2018, 24: 7727-7735. PMID: 30370903, PMCID: PMC6216479, DOI: 10.12659/msm.910216.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesPregnancy outcomesCongenital syphilisPregnant womenFirst antenatal care visitEligible pregnant womenPrevention of motherAntenatal care visitsIndependent risk factorMultivariable regression analysisLogistic regression analysisRegression analysisChild transmissionMaternal syphilisAntenatal careCare visitsNeonatal asphyxiaNeonatal deathFirst trimesterRisk womenAntibody titersAntenatal testingEpidemiological characteristicsRisk factorsSyphilis diagnosis
2017
HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China
Liu Y, Vermund SH, Ruan Y, Liu H, Zhang C, Yin L, Shao Y, Qian HZ. HIV testing and sexual risks among migrant men who have sex with men: findings from a large cross-sectional study in Beijing, China. AIDS Care 2017, 30: 86-94. PMID: 28944685, PMCID: PMC6088860, DOI: 10.1080/09540121.2017.1381331.Peer-Reviewed Original ResearchConceptsLifetime male sexual partnersCondomless receptive anal sexHIV testingMigrant MSMHIV perceptionAnal sexHIV/syphilis infectionOlder ageLarge cross-sectional studyHIV/STI riskLikelihood of syphilisHIV/syphilisInsertive anal sexReceptive anal sexCross-sectional studyMale sexual partnersSyphilis infectionHIV transmissionLocal MSMSTI riskChinese MSMLower oddsEpidemiological studiesSexual partnersRisk profile
2016
Frequent HIV Testing
Liu Y, Qian HZ, Ruan Y, Wu P, Osborn CY, Jia Y, Yin L, Lu H, He X, Shao Y, Vermund SH. Frequent HIV Testing. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 452-461. PMID: 27003496, PMCID: PMC4925192, DOI: 10.1097/qai.0000000000001001.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression analysisCurrent HIV infectionHIV incidence reductionHIV testing historyPropensity score adjustmentCubic spline modelingBorderline significant trendLogistic regression analysisHigher testing ratesHIV infectionHIV serostatusPrevious HIVHIV epidemicBeijing MSMTesting ratesScore adjustmentIncidence reductionTesting historyHIVInfection statusBehavioral factorsRegression analysisMSMOddsMenEngagement of Men in Antenatal Care Services: Increased HIV Testing and Treatment Uptake in a Community Participatory Action Program in Mozambique
Audet CM, Blevins M, Chire YM, Aliyu MH, Vaz LM, Antonio E, Alvim F, Bechtel R, Wester CW, Vermund SH. Engagement of Men in Antenatal Care Services: Increased HIV Testing and Treatment Uptake in a Community Participatory Action Program in Mozambique. AIDS And Behavior 2016, 20: 2090-2100. PMID: 26906021, PMCID: PMC4995150, DOI: 10.1007/s10461-016-1341-x.Peer-Reviewed Original ResearchConceptsAntenatal careHIV testingPregnant womenProvider-initiated counselingAntenatal care servicesAntiretroviral therapy servicesPre-post intervention designUptake of ARTTraditional birth attendantsMale engagementCommunity health agentsRate of testingANC servicesTreatment uptakeBirth attendantsService uptakePartner's pregnancyCare servicesTherapy servicesHealth agentsTreatment acceptabilityMale partnersSimilar interventionsMale championsPregnancy
2015
Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia
Parham GP, Mwanahamuntu MH, Kapambwe S, Muwonge R, Bateman AC, Blevins M, Chibwesha CJ, Pfaendler KS, Mudenda V, Shibemba AL, Chisele S, Mkumba G, Vwalika B, Hicks ML, Vermund SH, H. BH, Stringer JS, Sankaranarayanan R, Sahasrabuddhe VV. Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia. PLOS ONE 2015, 10: e0122169. PMID: 25885821, PMCID: PMC4401717, DOI: 10.1371/journal.pone.0122169.Peer-Reviewed Original ResearchConceptsCervical cancer prevention programsCancer prevention programsHistopathologic evaluationCervical intraepithelial neoplasia grade 2Cervical cancer prevention servicesPrevention programsHIV-negative womenInvasive cervical cancerCancer prevention servicesCervical cancer preventionExpert physician opinionHIV/AIDS programsElectronic medical recordsLow-resource countriesProportion of womenSame-day servicesLow-resource settingsUnscreened womenEvaluable dataCervical diseaseCervical cancerScreening servicesMedical recordsCancer preventionCervical precancerViral co-infections in high-risk communities of Pakistan
Shah AA, Abidi SH, Kalish ML, Vermund SH, Ali S. Viral co-infections in high-risk communities of Pakistan. The Lancet HIV 2015, 2: e124-e125. PMID: 26424672, DOI: 10.1016/s2352-3018(15)00039-9.Peer-Reviewed Original Research
2014
Antiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning
Moon TD, Ossemane EB, Green AF, Ndatimana E, José E, Buehler CP, Wester CW, Vermund SH, Olupona O. Antiretroviral Therapy Program Expansion in Zambézia Province, Mozambique: Geospatial Mapping of Community-Based and Health Facility Data for Integrated Health Planning. PLOS ONE 2014, 9: e109653. PMID: 25329169, PMCID: PMC4201452, DOI: 10.1371/journal.pone.0109653.Peer-Reviewed Original ResearchConceptsHIV populationZambézia ProvinceCommunity-based VCTCommunity-based voluntary counselingHIV testing resultsProgram demographic informationHIV seropositivity rateHealth facility dataProgram expansionHIV careVoluntary counselingSeropositivity rateTesting deliveryEvidence-based decisionsHealth planningTreatment monitoringGeospatial mappingDemographic informationHealth estimatesClinicFacility dataCommunity-BasedProgram planningCareVCTClinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia
Bateman AC, Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Kapambwe S, Katundu K, Nkole T, Mulundika J, Pfaendler KS, Hicks ML, Shibemba A, Vermund SH, Stringer JS, Chibwesha CJ. Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 212-215. PMID: 24977474, PMCID: PMC4162769, DOI: 10.1097/qai.0000000000000270.Peer-Reviewed Original ResearchConceptsClinical performanceDigital cervicographyCervical intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsCervical cancer screeningSquamous intraepithelial lesionsIntraepithelial lesionsCancer screeningCervicographyGrade 2HIVCytologyWomenLesionsVisual inspectionSpecificityHome-Based HIV Testing for Men Who Have Sex with Men in China: A Novel Community-Based Partnership to Complement Government Programs
Tao J, Li MY, Qian HZ, Wang LJ, Zhang Z, Ding HF, Ji YC, Li DL, Xiao D, Hazlitt M, Vermund SH, Xiu X, Bao Y. Home-Based HIV Testing for Men Who Have Sex with Men in China: A Novel Community-Based Partnership to Complement Government Programs. PLOS ONE 2014, 9: e102812. PMID: 25051160, PMCID: PMC4106852, DOI: 10.1371/journal.pone.0102812.Peer-Reviewed Original ResearchMonitoring the performance of “screen‐and‐treat” cervical cancer prevention programs
Mwanahamuntu MH, Sahasrabuddhe VV, Blevins M, Kapambwe S, Shepherd BE, Chibwesha C, Pfaendler KS, Mkumba G, Vwalika B, Hicks ML, Vermund SH, Stringer JSA, Parham GP. Monitoring the performance of “screen‐and‐treat” cervical cancer prevention programs. International Journal Of Gynecology & Obstetrics 2014, 126: 88-89. PMID: 24810795, PMCID: PMC4123629, DOI: 10.1016/j.ijgo.2014.01.006.Peer-Reviewed Original ResearchHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm B
2013
Combination Prevention: New Hope for Stopping the Epidemic
Vermund SH, Hayes RJ. Combination Prevention: New Hope for Stopping the Epidemic. Current HIV/AIDS Reports 2013, 10: 169-186. PMID: 23456730, PMCID: PMC3642362, DOI: 10.1007/s11904-013-0155-y.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAnti-HIV AgentsFemaleHealth Knowledge, Attitudes, PracticeHealth PolicyHealth Services AccessibilityHIV InfectionsHumansInfectious Disease Transmission, VerticalMaleMass ScreeningPatient Acceptance of Health CarePregnancyPregnancy Complications, InfectiousRisk Reduction BehaviorSex WorkersSexual BehaviorSocial StigmaSocioeconomic FactorsWorld Health OrganizationConceptsAntiretroviral therapyVoluntary medical male circumcisionCombination prevention approachesOral antiretroviral drugsPre-exposure prophylaxisMedical male circumcisionSuccessful viral suppressionConsistent condom useEvidence-based modalitiesBoost vaccineViral suppressionHIV testingAntiretroviral coverageHIV transmissionAntiretroviral drugsBlood screeningVaginal microbicidesClean needlesInfection controlAdolescent sexual debutTransmission reductionFemale condomMale circumcisionSingle interventionHIV researchPredictors of HIV Testing Among Men Who Have Sex With Men in a Large Chinese City
Zhang L, Xiao Y, Lu R, Wu G, Ding X, Qian HZ, McFarland W, Ruan Y, Vermund SH, Shao Y. Predictors of HIV Testing Among Men Who Have Sex With Men in a Large Chinese City. Sexually Transmitted Diseases 2013, 40: 235-240. PMID: 23403605, PMCID: PMC3725775, DOI: 10.1097/olq.0b013e31827ca6b9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyAsian PeopleChinaCross-Sectional StudiesEducational StatusGovernment ProgramsHealth Knowledge, Attitudes, PracticeHealth PromotionHealth Services AccessibilityHIV InfectionsHomosexuality, MaleHumansMaleMass ScreeningOdds RatioPrevalenceRisk FactorsSexual PartnersSurveys and QuestionnairesUrban PopulationConceptsHIV testingAnal sexHIV testing ratesLow HIV riskReceptive anal sexCross-sectional studyRecent male partnersRespondent-driven samplingHIV testHIV infectionHIV riskHealth staffTesting ratesChinese menMale partnersNonjudgmental environmentFear of discriminationReceptive roleSexMenPositive resultsMSMPrevalenceSex preferenceRisk
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program