2020
Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis.
Graybill LA, Kasaro M, Freeborn K, Walker JS, Poole C, Powers KA, Mollan KR, Rosenberg NE, Vermund SH, Mutale W, Chi BH. Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. AIDS 2020, 34: 761-776. PMID: 32167990, PMCID: PMC7275092, DOI: 10.1097/qad.0000000000002487.Peer-Reviewed Original ResearchConceptsBreast-feeding womenMaternal HIV incidenceHIV incidenceHIV acquisitionIncidence rateHIV preventionSystematic reviewHigh HIV incidencePartner's HIV statusHIV incidence ratesCombination HIV preventionNonpregnant periodsIncident HIVTreatment landscapeHIV statusSaharan AfricaElevated riskSummary estimatesRelevant conferencesIncidenceAverage incidenceLimited evidenceWomenCalendar timePrevention
2018
Partners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol
Audet CM, Graves E, Barreto E, De Schacht C, Gong W, Shepherd BE, Aboobacar A, Gonzalez-Calvo L, Alvim MF, Aliyu MH, Kipp AM, Jordan H, Amico KR, Diemer M, Ciaranello A, Dugdale C, Vermund SH, Van Rompaey S. Partners-based HIV treatment for seroconcordant couples attending antenatal and postnatal care in rural Mozambique: A cluster randomized trial protocol. Contemporary Clinical Trials 2018, 71: 63-69. PMID: 29879469, PMCID: PMC6067957, DOI: 10.1016/j.cct.2018.05.020.Peer-Reviewed Original ResearchConceptsChild transmissionSeroconcordant couplesMale partnersResource-limited rural settingsElimination of motherRoutine clinical dataUptake of servicesClinical trial designMale partner approvalAntiretroviral therapyHIV careAntenatal careRural MozambiqueHIV servicesPostnatal carePregnant womenHIV treatmentTrial protocolClinical dataHealth facilitiesTrial designHIVNewborn childrenPartner approvalEngagement interventions
2004
Prevention of mother-to-child transmission of HIV in Africa.
Vermund SH. Prevention of mother-to-child transmission of HIV in Africa. Topics In Antiviral Medicine 2004, 12: 130-4. PMID: 15647608.Peer-Reviewed Original ResearchConceptsChild transmissionHIV infectionInternational AIDS Society-USA courseMaternal plasma viral loadExclusive formula feedingNevirapine resistance mutationsSingle-dose nevirapinePrevention of motherPlasma viral loadPerinatal transmission ratePerinatal transmissionAntiretroviral therapyExclusive breastfeedingFormula feedingViral loadMaternal mortalityRisk factorsMortality rateHIVAfrican childrenMixed feedingGreater riskResistance mutationsEarly weaningBreastfeeding
2003
Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine
Stringer J, Sinkala M, Chapman V, Acosta EP, Aldrovandi GM, Mudenda V, Stout JP, Goldenberg RL, Kumwenda R, Vermund SH. Timing of the maternal drug dose and risk of perinatal HIV transmission in the setting of intrapartum and neonatal single-dose nevirapine. AIDS 2003, 17: 1659-1665. PMID: 12853748, PMCID: PMC2745973, DOI: 10.1097/00002030-200307250-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBreast FeedingDrug Administration ScheduleFemaleHIV InfectionsHIV SeropositivityHumansInfant, NewbornInfectious Disease Transmission, VerticalLabor, ObstetricNevirapineObstetric Labor ComplicationsPregnancyPregnancy Complications, InfectiousProspective StudiesReverse Transcriptase InhibitorsRisk FactorsTime FactorsConceptsPerinatal HIV transmissionHIV transmissionInfant HIV infection statusNeonatal single-dose nevirapineMaternal drug doseSingle-dose nevirapineHIV infection statusProspective cohort studyPerinatal transmission rateOnset of laborMain outcome measuresMean drug concentrationWeeks of lifeRisk of transmissionNVP levelsNVP prophylaxisNVP syrupObstetrical clinicPerinatal transmissionCohort studyOral doseViral loadPregnant womenPolymerase chain reactionRisk factors
2002
Perinatal HIV transmission: developing country considerations
Goldenberg RL, Stringer JS, Sinkala M, Vermund SH. Perinatal HIV transmission: developing country considerations. The Journal Of Maternal-Fetal & Neonatal Medicine 2002, 12: 149-158. PMID: 12530611, DOI: 10.1080/jmf.12.3.149.158.Peer-Reviewed Original ResearchConceptsMaternal HIV infectionMaternal-child transmissionObstetric care systemTransmission of HIVMortality rate 10HIV infectionAntiviral therapyPregnant womenChildhood mortalityInfantsHIVCare systemDevastating problemEarly childhoodInfectionMothersSubstantial additional resourcesTherapyMortalityPrevalenceWomen
1999
Prevention of mother-to-child transmission of HIV-1
Stringer J, Vermund S. Prevention of mother-to-child transmission of HIV-1. Current Opinion In Obstetrics & Gynecology 1999, 11: 427-434. PMID: 10526917, DOI: 10.1097/00001703-199910000-00003.Peer-Reviewed Original ResearchConceptsChild transmissionHIV-1Infant formula supplementationPrevention of motherHIV-1 transmissionCombination drug regimensResource-poor settingsFormula supplementationAntiretroviral therapyCesarean deliveryAntiretroviral agentsBreast feedingDrug regimensRandomized trialsPoor settingsInfectious diseasesInfant survivalSubstantial proportionPreliminary dataMothersLower ratesCost implicationsDeliveryRegimensPatients