2024
Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHIV InfectionsHumansMass ScreeningPredictive Value of TestsSouth AfricaZambiaConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2023
Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis
Zhou Y, Zhang X, Gao Y, Alvi R, Erqou S, Chen Y, Wang H, Wang W, Li X, Zanni M, Neilan T, Vermund S, Qian H, Qian F. Risk of death and readmission among individuals with heart failure and HIV: A systematic review and meta-analysis. Journal Of Infection And Public Health 2023, 17: 70-75. PMID: 37992436, DOI: 10.1016/j.jiph.2023.11.004.Peer-Reviewed Original ResearchConceptsHeart failureHF patientsRisk of HFHuman immunodeficiency virus statusPoor HF outcomesRisk of deathWeb of ScienceCause deathCause readmissionHF outcomesAdult patientsCohort studyHIV infectionHIV statusCochrane LibraryIndependent associationVirus statusHigh riskDeath outcomesHIVReadmissionPatientsSystematic reviewSystematic searchRiskIncreasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study
Ransome Y, Taggart T, Huang A, Vermund S, Mayer K, Nunn A. Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 196-202. PMID: 37850978, DOI: 10.1097/qai.0000000000003278.Peer-Reviewed Original ResearchConceptsHIV seroconversionHIV incidenceBehavioral HIV prevention interventionsLower HIV incidenceProportional hazards regressionHIV prevention interventionsBlack menSpiritual beliefsOne-unit increaseHazards regressionLongitudinal riskPrevention interventionsHIVBiomedical assessmentLower hazard rateLongitudinal studyMenMonthsSeroconversionLongitudinal analysisReligious service attendanceIncidenceBaselineBMSMHigher proportionBrief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa
Yang B, Sloot R, Floyd S, Awoniyi D, Griffith S, Ayles H, Fidler S, Hayes R, Vermund S, Bock P, team H. Brief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 300-304. PMID: 37001128, PMCID: PMC10313787, DOI: 10.1097/qai.0000000000003197.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Retroviral AgentsFemaleHIV InfectionsHIV TestingHumansMaleResearchSouth AfricaZambiaConceptsHIV testingHousehold visitsWeekday shiftsNumber of menCommunity HIV care providersCommunity-based HIV testingHIV care providersHPTN 071 (PopART) trialUnknown HIV statusHigh-burden settingsAntiretroviral treatment coverageCommunity-based trialHigh-risk behaviorsCommunity-based servicesPopART interventionHIV statusHIV epidemicTreatment coverageCare providersLinear regression analysisStudy questionnaireMore menRecruitment of menVisitsWomenCombination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIVHigh-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsDrug Resistance, ViralGenotypeHIV InfectionsHIV-1HumansKazakhstanMutationPhylogenyConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men?
Lin Y, Gao Y, Sun Y, Turner D, Zou H, Vermund S, Qian H. Does Voluntary Medical Male Circumcision Reduce HIV Risk in Men Who Have Sex with Men? Current HIV/AIDS Reports 2022, 19: 522-525. PMID: 36520379, DOI: 10.1007/s11904-022-00637-7.Peer-Reviewed Original ResearchMeSH KeywordsCircumcision, MaleHIV InfectionsHumansMaleRisk Reduction BehaviorSexual and Gender MinoritiesSexual BehaviorConceptsVoluntary medical male circumcisionRandomized clinical trialsHIV riskMedical male circumcisionPurpose of ReviewToSubgroup of menHIV prevalenceClinical trialsAnal sexMale circumcisionPopulation-level impactAvailable evidenceMSMInsertive roleConflicting resultsMenSexRiskOriginal studyEfficacyInterventionEvidenceReviewToStrong evidencePrevalenceVoluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaCircumcision, MaleFemaleHIV InfectionsHumansIncidenceMalePrevalenceConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth sectionVoluntary Medical Male Circumcision for HIV Prevention: a Global Overview
Zhang C, Vermund S. Voluntary Medical Male Circumcision for HIV Prevention: a Global Overview. Current HIV/AIDS Reports 2022, 19: 474-483. PMID: 36348186, DOI: 10.1007/s11904-022-00632-y.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionMedical male circumcisionHIV preventionMale circumcisionPrevention strategiesEvidence-based HIV prevention strategiesBehavioral prevention strategiesHigher sexual risk behaviorsHIV prevention strategiesSexual risk behaviorsPurpose of ReviewWithDecreased riskClinical trialsCircumcision coverageVMMC coverageProtective effectRecent FindingsThereHealth professionalsSystematic reviewIncidence areaRisk behaviorsSexual partnersHealth authoritiesHealth systemMale partnersProjected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study
Probert W, Sauter R, Pickles M, Cori A, Bell-Mandla N, Bwalya J, Abeler-Dörner L, Bock P, Donnell D, Floyd S, Macleod D, Piwowar-Manning E, Skalland T, Shanaube K, Wilson E, Yang B, Ayles H, Fidler S, Hayes R, Fraser C, Team H, Hayes R, Fidler S, Beyers N, Ayles H, Bock P, El-Sadr W, Cohen M, Eshleman S, Agyei Y, Piwowar-Manning E, Bond V, Hoddinott G, Donnell D, Floyd S, Wilson E, Emel L, Noble H, Macleod D, Burns D, Fraser C, Cori A, Sista N, Griffith S, Moore A, Headen T, White R, Miller E, Hargreaves J, Hauck K, Thomas R, Limbada M, Bwalya J, Pickles M, Sabapathy K, Schaap, Dunbar R, Shanaube K, Yang B, Simwinga M, Smith P, Vermund S, Mandla N, Makola N, van Deventer A, James A, Jennings K, Kruger J, Phiri M, Kosloff B, Mwenge L, Kanema S, Sauter R, Probert W, Kumar R, Sakala E, Silumesi A, Skalland T, Yuhas K. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study. The Lancet HIV 2022, 9: e771-e780. PMID: 36332654, PMCID: PMC9646978, DOI: 10.1016/s2352-3018(22)00259-4.Peer-Reviewed Original ResearchConceptsStandard of careHome-based testingCluster-randomised trialHigh-prevalence communitiesHIV incidenceHIV epidemicNational guidelinesNational InstituteUniversal testingHIV care cascadeAntiretroviral therapy uptakeUS President's Emergency PlanGeneralised HIV epidemicPresident's Emergency PlanPopART interventionCare cascadeART eligibilityArm BTherapy uptakeTrial interventionTrial dataInfectious diseasesAIDS ReliefIntervention impactDrug abuseAntiretroviral therapy resistance mutations among HIV infected people in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Mukhatayev Z, Bayserkin B, Vermund SH, Ali S. Antiretroviral therapy resistance mutations among HIV infected people in Kazakhstan. Scientific Reports 2022, 12: 17195. PMID: 36229577, PMCID: PMC9562405, DOI: 10.1038/s41598-022-22163-7.Peer-Reviewed Original ResearchCommunity mobilisation to achieve HIV testing and care goals
Vermund SH. Community mobilisation to achieve HIV testing and care goals. The Lancet HIV 2022, 9: e597-e598. PMID: 36055289, PMCID: PMC10773955, DOI: 10.1016/s2352-3018(22)00218-1.Peer-Reviewed Original Research“If it weren’t for my traditional healer, I would be dead”: Engaging traditional healers to support people living with HIV in rural Mozambique
Audet CM, Pettapiece-Phillips M, Tian Y, Shepherd BE, Vermund SH, Salato J. “If it weren’t for my traditional healer, I would be dead”: Engaging traditional healers to support people living with HIV in rural Mozambique. PLOS ONE 2022, 17: e0270565. PMID: 35763519, PMCID: PMC9239464, DOI: 10.1371/journal.pone.0270565.Peer-Reviewed Original ResearchMeSH KeywordsHealth FacilitiesHIV InfectionsHumansMedicine, African TraditionalMozambiqueRural PopulationConceptsTraditional healersPsychosocial supportCommunity health worker interventionPre-post intervention study designWorker interventionHealth worker interventionMedication possession ratioMedication side effectsIntervention study designPositive test resultsHome-based supportObserved therapyPossession ratioClinical outcomesHIV treatmentPoor adherencePost-intervention participantsHealth facilitiesPatient's desireSide effectsZambézia ProvinceCare servicesStudy designHIVTherapyCOVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review
Huang D, Zunong J, Li M, Li D, Gong J, Vermund SH, Hu Y. COVID-19 Clinical Presentation Among HIV-Infected Persons in China: A Systematic Review. Current HIV/AIDS Reports 2022, 19: 167-176. PMID: 35394249, PMCID: PMC8990500, DOI: 10.1007/s11904-022-00606-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChinaCOVID-19COVID-19 TestingHIV InfectionsHumansMaleMiddle AgedPandemicsSARS-CoV-2Young AdultConceptsAntiretroviral therapyCOVID-19 clinical severityCOVID-19 clinical presentationCOVID-19Undetectable viral loadAsymptomatic COVID-19Severe COVID-19Last clinical visitCase series/reportsCase fatality rateCOVID-19 prognosisLate antiretroviral therapyIL-6 resultsSARS-CoV-2COVID-19 diagnosisMedian CD4Gastrointestinal symptomsHIV infectionMedian ageRespiratory distressClinical featuresClinical presentationClinical visitsViral loadClinical detailsIntersecting Pandemics of HIV and SARS-CoV-2: Commentary on the Special Issue
Vermund SH. Intersecting Pandemics of HIV and SARS-CoV-2: Commentary on the Special Issue. Current HIV/AIDS Reports 2022, 19: 1-4. PMID: 35192108, PMCID: PMC8862004, DOI: 10.1007/s11904-022-00599-w.Peer-Reviewed Original ResearchTreatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study
Jia J, Zhu Q, Deng L, Lan G, Johnson A, Chen H, Shen Z, Li J, Xing H, Ruan Y, Li J, Lu H, Vermund SH, Zhu J, Qian HZ. Treatment outcomes of HIV patients with hepatitis B and C virus co-infections in Southwest China: an observational cohort study. Infectious Diseases Of Poverty 2022, 11: 7. PMID: 34986877, PMCID: PMC8734096, DOI: 10.1186/s40249-021-00921-5.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusAntiretroviral therapyHigh mortalityHCV coinfectionC virusNational Free Antiretroviral Treatment ProgramHBV co-infected patientsHBV/HCV coinfectionRetrospective cohort study analysisEffect of ARTCohort study analysisObservational cohort studyAntiretroviral treatment programOverall mortality rateProportional hazards modelTreatment attrition rateCause deathHCV-coHIV patientsBaseline infectionCohort studyHBV-HCVHepatitis BHepatitis treatment
2021
Leveraging HIV Care Infrastructures for Integrated Chronic Disease and Pandemic Management in Sub-Saharan Africa
Brault MA, Vermund SH, Aliyu MH, Omer SB, Clark D, Spiegelman D. Leveraging HIV Care Infrastructures for Integrated Chronic Disease and Pandemic Management in Sub-Saharan Africa. International Journal Of Environmental Research And Public Health 2021, 18: 10751. PMID: 34682492, PMCID: PMC8535610, DOI: 10.3390/ijerph182010751.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaChronic DiseaseCOVID-19HIV InfectionsHumansPandemicsSARS-CoV-2ConceptsNon-communicable diseasesNon-communicable disease careInfectious diseasesHIV care infrastructureTropical infectious diseasesHIV/AIDS epidemicIntegrated service delivery modelCOVID-19Future pandemic threatsLow-cost interventionMinistry of HealthDisease careChronic diseasesCardiovascular diseaseSuch careIntegrated careAIDS ReliefHealth systemSub-Saharan AfricaDiseaseService delivery modelsPandemic threatAIDS epidemicCare infrastructureHealthcare modelReport From the National Academies of Sciences, Engineering and Medicine—STI: Adopting a Sexual Health Paradigm—A Synopsis for Sexually Transmitted Infection Practitioners, Clinicians, and Researchers
Rietmeijer CA, Kissinger PJ, Guilamo-Ramos V, Gaydos CA, Hook EW, Mead A, Yang S, Geller A, Vermund SH. Report From the National Academies of Sciences, Engineering and Medicine—STI: Adopting a Sexual Health Paradigm—A Synopsis for Sexually Transmitted Infection Practitioners, Clinicians, and Researchers. Sexually Transmitted Diseases 2021, 49: 169-175. PMID: 34475355, PMCID: PMC9365299, DOI: 10.1097/olq.0000000000001552.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultHIV InfectionsHumansPublic HealthSexual BehaviorSexual HealthSexually Transmitted DiseasesConceptsSexual health paradigmMedicine reportFuture public health programsDisease intervention specialistsSexual health practitionersPublic health staffCommunity outreach workersPublic health advancesPublic health programsTransmitted InfectionsSTI managementHealth staffHidden epidemicHealth paradigmSexual healthHealth programsReportable STIsSexual debutHealth practitionersSTIsOutreach workersHealth advancesIntervention specialistsInfectionCliniciansUnderstanding HIV outbreak among children in a rural community of Sindh province of Pakistan.
Altaf A, Shah SA, Khanani R, Vermund SH. Understanding HIV outbreak among children in a rural community of Sindh province of Pakistan. Journal Of The Pakistan Medical Association 2021, 71(Suppl 4): s1-s4. PMID: 34469421, PMCID: PMC10768810.Peer-Reviewed Original ResearchHepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan
Mukhatayeva A, Mustafa A, Dzissyuk N, Issanov A, Bayserkin B, Vermund SH, Ali S. Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan. Scientific Reports 2021, 11: 13542. PMID: 34188081, PMCID: PMC8241865, DOI: 10.1038/s41598-021-92688-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionFemaleHepatitis BHepatitis C, ChronicHIV InfectionsHumansKazakhstanMaleTuberculosisConceptsStudy participantsHepatitis CHepatitis BRegular screeningHIV-positive study participantsHCV/HBVHIV-positive patientsTB/HIVHIV/HCVDirect acting antiviralsHIV/tuberculosisOpiate substitution therapyInjection drug useHarm reduction effortsAvailability of ARTHCV infectionTB infectionActing antiviralsCertain age groupsPositive patientsHIV infectionHIV prevalenceSubstitution therapyVaccination protocolsQuadruple infections