2024
Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHIV InfectionsHumansMass ScreeningPredictive Value of TestsSouth AfricaZambiaConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2023
Brief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa
Yang B, Sloot R, Floyd S, Awoniyi D, Griffith S, Ayles H, Fidler S, Hayes R, Vermund S, Bock P, team H. Brief Report: How Do We Reach Men? Offering HIV Testing in Evenings and Weekends in the HPTN 071 (PopART) Community-Based Trial in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 300-304. PMID: 37001128, PMCID: PMC10313787, DOI: 10.1097/qai.0000000000003197.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-Retroviral AgentsFemaleHIV InfectionsHIV TestingHumansMaleResearchSouth AfricaZambiaConceptsHIV testingHousehold visitsWeekday shiftsNumber of menCommunity HIV care providersCommunity-based HIV testingHIV care providersHPTN 071 (PopART) trialUnknown HIV statusHigh-burden settingsAntiretroviral treatment coverageCommunity-based trialHigh-risk behaviorsCommunity-based servicesPopART interventionHIV statusHIV epidemicTreatment coverageCare providersLinear regression analysisStudy questionnaireMore menRecruitment of menVisitsWomen
2022
Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study
Probert W, Sauter R, Pickles M, Cori A, Bell-Mandla N, Bwalya J, Abeler-Dörner L, Bock P, Donnell D, Floyd S, Macleod D, Piwowar-Manning E, Skalland T, Shanaube K, Wilson E, Yang B, Ayles H, Fidler S, Hayes R, Fraser C, Team H, Hayes R, Fidler S, Beyers N, Ayles H, Bock P, El-Sadr W, Cohen M, Eshleman S, Agyei Y, Piwowar-Manning E, Bond V, Hoddinott G, Donnell D, Floyd S, Wilson E, Emel L, Noble H, Macleod D, Burns D, Fraser C, Cori A, Sista N, Griffith S, Moore A, Headen T, White R, Miller E, Hargreaves J, Hauck K, Thomas R, Limbada M, Bwalya J, Pickles M, Sabapathy K, Schaap, Dunbar R, Shanaube K, Yang B, Simwinga M, Smith P, Vermund S, Mandla N, Makola N, van Deventer A, James A, Jennings K, Kruger J, Phiri M, Kosloff B, Mwenge L, Kanema S, Sauter R, Probert W, Kumar R, Sakala E, Silumesi A, Skalland T, Yuhas K. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study. The Lancet HIV 2022, 9: e771-e780. PMID: 36332654, PMCID: PMC9646978, DOI: 10.1016/s2352-3018(22)00259-4.Peer-Reviewed Original ResearchConceptsStandard of careHome-based testingCluster-randomised trialHigh-prevalence communitiesHIV incidenceHIV epidemicNational guidelinesNational InstituteUniversal testingHIV care cascadeAntiretroviral therapy uptakeUS President's Emergency PlanGeneralised HIV epidemicPresident's Emergency PlanPopART interventionCare cascadeART eligibilityArm BTherapy uptakeTrial interventionTrial dataInfectious diseasesAIDS ReliefIntervention impactDrug abuseEstimating non-communicable disease treatment costs using probability-based cost estimation
Botha CR, Vermund SH. Estimating non-communicable disease treatment costs using probability-based cost estimation. Global Health Action 2022, 15: 2008627. PMID: 35147492, PMCID: PMC8843315, DOI: 10.1080/16549716.2021.2008627.Peer-Reviewed Original ResearchMeSH KeywordsHealth Care CostsHumansMortality, PrematureNoncommunicable DiseasesProbabilitySouth AfricaConceptsLevel dataCost estimationPublic financial resourcesDisease treatment costsSub-Saharan AfricaFuture costsHealthcare facility levelFinancial resourcesMiddle-income countriesCost estimatesInput variablesAvailability of dataResource allocationHealth sectorTotal costNon-communicable diseasesData-poor environmentsCostCountriesMean costPatient-level dataTreatment costsSouth AfricaTrend dataVariables
2021
Community-based health workers implementing universal access to HIV testing and treatment: lessons from South Africa and Zambia—HPTN 071 (PopART)
Viljoen L, Mainga T, Casper R, Mubekapi-Muzadaidzwa C, Wademan D, Bond V, Pliakas T, Bwalya C, Stangl A, Phiri M, Yang B, Shanaube K, Bock P, Fidler S, Hayes R, Ayles H, Hargreaves J, Hoddinott G, Seeley J, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Eshleman S, Macleod D, Moore A, Vermund S, Hauck K, Shanaube K. Community-based health workers implementing universal access to HIV testing and treatment: lessons from South Africa and Zambia—HPTN 071 (PopART). Health Policy And Planning 2021, 36: 881-890. PMID: 33963387, PMCID: PMC8227454, DOI: 10.1093/heapol/czab019.Peer-Reviewed Original ResearchConceptsCommunity-based health workersHIV testingHealth workersHIV prevention packageHPTN 071 (PopART) trialHIV epidemic controlPopulation health benefitsPopART interventionCHW interventionPrevention packageTreatment servicesIntervention staffTrial outcomesBaseline quantitative dataReferral servicesCHW retentionHealth benefitsIntervention packageProcess evaluationEpidemic controlGroup discussionsInterventionTrialsKey informant interviewsEmotional support
2020
An unrecognized key population? Traditional treatment practices associated with HIV risk among traditional healers in rural South Africa.
Audet CM, Ngobeni S, Mkansi M, Wafawanaka F, Aliyu MH, Vermund SH, Wagner RG. An unrecognized key population? Traditional treatment practices associated with HIV risk among traditional healers in rural South Africa. AIDS 2020, 34: 2313-2317. PMID: 33048882, PMCID: PMC7674239, DOI: 10.1097/qad.0000000000002710.Peer-Reviewed Original ResearchConceptsSkin incisionPatient's bloodHIV testTraditional healersHIV prevalenceKey populationsRapid HIV testsRisk of acquisitionHigh HIV prevalenceBlood-borne pathogensTraditional treatment practicesSouth African traditional healersPositive test resultsCross-sectional surveyPersonal protective equipmentHIV acquisitionHIV infectionPosttest counselingPretest counselingHIV riskOccupational exposureMAIN OUTCOMERural South AfricaHIVAfrican traditional healersIntegrating and Interpreting Findings from the Latest Treatment as Prevention Trials
Brault MA, Spiegelman D, Abdool Karim SS, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports 2020, 17: 249-258. PMID: 32297219, PMCID: PMC7260110, DOI: 10.1007/s11904-020-00492-4.Peer-Reviewed Original Research
2019
Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherence
2018
“I will leave the baby with my mother”: Long‐distance travel and follow‐up care among HIV‐positive pregnant and postpartum women in South Africa
Clouse K, Fox MP, Mongwenyana C, Motlhatlhedi M, Buthelezi S, Bokaba D, Norris SA, Bassett J, Lurie MN, Aronoff DM, Vermund SH. “I will leave the baby with my mother”: Long‐distance travel and follow‐up care among HIV‐positive pregnant and postpartum women in South Africa. Journal Of The International AIDS Society 2018, 21: e25121. PMID: 30027665, PMCID: PMC6053484, DOI: 10.1002/jia2.25121.Peer-Reviewed Original ResearchConceptsSouth AfricaNine provincesMotivation of travelLong-distance travelSouth Africa's nine provincesPostpartum womenPeripartum periodGreater JohannesburgSouth African provincesCare of familiesFragmented healthcare systemContinuity of HIVHIV-positive womenMobile populationsTravel patternsUrban African settingAfrican provincesJohannesburgHealthcare accessFrequent travelMedian durationMedian ageDiverse clinicsFrequent mobilityGauteng Province
2017
Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, Bell-Mandla N, Smith P, Floyd S, Bock P, Ayles H, Beyers N, Donnell D, Fidler S, Hayes R, Hauck K, Team H, Hargreaves J, Watson-Jones D, Godfrey-Faussett P, Cori A, Pickles M, Mandla N, Yang B, James A, Vermaak R, Makola N, Hoddinott G, Naidoo V, Bond V, Simwinga M, Mwinga A, Kosloff B, Limbada M, Bwalya J, Ngulube C, Fraser C, Eshleman S, Agyei Y, Cummings V, Catalano D, Emel L, Bunts L, Noble H, Burns D, Kouda A, Sista N, Moore A, White R, Headen T, Miller E, Hinson K, Vermund S, Barnes M, Horn L, Mwango A, Baldwin M, Wolf S, Hughes E. Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial. The Lancet Global Health 2017, 5: e1133-e1141. PMID: 28964756, PMCID: PMC5640509, DOI: 10.1016/s2214-109x(17)30367-4.Peer-Reviewed Original ResearchConceptsHIV-negative peopleHIV-positive individualsHIV-negative individualsAntiretroviral therapyHealth-related qualityHIV careHRQoL scoresHIV statusHerpes simplex virus type-2 statusNational InstituteHPTN 071 (PopART) studyHPTN 071 (PopART) trialLaboratory-confirmed HIVType 2 statusCross-sectional baseline surveyLarge cross-sectional surveyRecreational drug useCross-sectional surveyPresident's Emergency PlanGeneral population sampleHRQoL informationBetter HRQoLHIV-negativeHIV progressionHRQoL dataMobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa
Clouse K, Vermund SH, Maskew M, Lurie MN, MacLeod W, Malete G, Carmona S, Sherman G, Fox MP. Mobility and Clinic Switching Among Postpartum Women Considered Lost to HIV Care in South Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 74: 383-389. PMID: 28225717, PMCID: PMC5324708, DOI: 10.1097/qai.0000000000001284.Peer-Reviewed Original ResearchConceptsHIV careNational Health Laboratory Service databaseLow CD4 cell countsNational Antiretroviral Therapy ProgramCD4 cell countObservational cohort studyAntiretroviral therapy programsAntiretroviral therapyCohort studyPostpartum womenPublic clinicsService databaseCell countTherapy programCareWomenLTFUClinicOne-thirdDaysPatientsPregnancyTherapy
2014
HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm BHPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model
Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, Eaton JW, Hauck K, Smith P, Griffith S, Moore A, Donnell D, Vermund SH, Fidler S, Hayes R, Fraser C, . HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model. PLOS ONE 2014, 9: e84511. PMID: 24454728, PMCID: PMC3893126, DOI: 10.1371/journal.pone.0084511.Peer-Reviewed Original ResearchMeSH KeywordsAIDS SerodiagnosisAnti-HIV AgentsCluster AnalysisHIV InfectionsHumansSouth AfricaZambiaConceptsAntiretroviral therapyArm AHIV incidenceHIV transmissionThree-arm cluster-randomized trialHIV combination prevention interventionsPopulation-level HIV incidenceCombination prevention interventionsCombination prevention packageHPTN 052 trialHPTN 071 (PopART) trialPopulation-level incidenceHIV-positive individualsHeterosexual HIV transmissionUptake of testingNational surveillance dataCluster-randomized trialImpact of treatmentLarge population clustersART retentionHPTN 071Primary endpointArm BPrevention packageControl arm
2013
Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmission
2012
Transitioning HIV care and treatment programs in southern Africa to full local management
Vermund SH, Sidat M, Weil LF, Tique JA, Moon TD, Ciampa PJ. Transitioning HIV care and treatment programs in southern Africa to full local management. AIDS 2012, 26: 1303-1310. PMID: 22706012, PMCID: PMC3576840, DOI: 10.1097/qad.0b013e3283552185.Peer-Reviewed Original ResearchConceptsHIV careHIV/AIDS care programsAIDS ProgramPrimary health care systemUS President's Emergency PlanHealth care workersAIDS care programsHealth worker capacityHIV/AIDS programsPresident's Emergency PlanHealth care systemHIV programsAIDS careCare managementCare workersCare programTreatment programAIDS ReliefHealth care managementCare systemCarePrevention endeavorsEmergency plans