2024
Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial.
Gao Y, Zhan Y, Sun Y, Zheng W, Zhang W, Fu L, Guo Z, Lin Y, Li Y, Zheng L, Zhan Y, Zhu Z, Duan J, Zhang G, Huang T, Su B, Yu M, Wu G, Ouyang L, Zhao J, Wang G, Zhou Y, Qian H, Fitzpatrick T, Vermund S, Zou H. Efficacy of Voluntary Medical Male Circumcision to Prevent HIV Infection Among Men Who Have Sex With Men : A Randomized Controlled Trial. Annals Of Internal Medicine 2024, 177: 719-728. PMID: 38801778, DOI: 10.7326/m23-3317.Peer-Reviewed Original ResearchVoluntary medical male circumcisionEfficacy of VMMCPreventing incident HIV infectionsRandomized controlled trialsMedical male circumcisionIncident HIV infectionIntervention groupInsertive anal intercoursePractice insertive anal intercourseMale circumcisionAnal intercourseIncidence rate of syphilisHIV infectionRates of syphilisMale sex partnersSexually transmitted infectionsIntention-to-treat analysisPrevent HIV infectionHIV incidenceControl groupHIV riskIncidence rateHerpes simplex virus type 2HIV seroconversionSelf-report
2023
Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study
Ransome Y, Taggart T, Huang A, Vermund S, Mayer K, Nunn A. Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 196-202. PMID: 37850978, DOI: 10.1097/qai.0000000000003278.Peer-Reviewed Original ResearchConceptsHIV seroconversionHIV incidenceBehavioral HIV prevention interventionsLower HIV incidenceProportional hazards regressionHIV prevention interventionsBlack menSpiritual beliefsOne-unit increaseHazards regressionLongitudinal riskPrevention interventionsHIVBiomedical assessmentLower hazard rateLongitudinal studyMenMonthsSeroconversionLongitudinal analysisReligious service attendanceIncidenceBaselineBMSMHigher proportionCombination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis
Powers K, Mutale W, Rosenberg N, Graybill L, Mollan K, Freeborn K, Saidi F, Maman S, Mulenga P, Jahn A, Nyirenda R, Stringer J, Vermund S, H. B. Combination HIV prevention during pregnancy and the post‐partum period in Malawi and Zambia: a mathematical modelling analysis. Journal Of The International AIDS Society 2023, 26: e26128. PMID: 37403422, PMCID: PMC10320044, DOI: 10.1002/jia2.26128.Peer-Reviewed Original ResearchConceptsFemale HIV transmissionMaternal HIV acquisitionMaternal HIV incidenceHIV prevention strategiesPost-partum periodAntiretroviral therapyHIV transmissionMale partnersHIV acquisitionHIV incidenceANC patientsPrevention strategiesCombination HIV prevention strategiesCombination HIV prevention interventionSuppressive antiretroviral therapyPre-exposure prophylaxisVertical HIV transmissionAntenatal care programsCombination HIV preventionHIV prevention interventionsANC initiationART initiationUnsuppressed HIVIncident infectionsUndiagnosed HIVHigh-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
Sanaubarova A, Pujol-Hodge E, Dzissyuk N, Lemey P, Vermund S, Brown A, Ali S. High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan. Viruses 2023, 15: 1407. PMID: 37515095, PMCID: PMC10384832, DOI: 10.3390/v15071407.Peer-Reviewed Original ResearchConceptsAntiretroviral therapySubtype A6Drug-resistant mutationsDrug resistanceEffective antiretroviral therapySuppressive antiretroviral therapyAntiretroviral drug resistanceDrug resistance monitoringHigh-level drug resistanceDrug regimensHIV incidenceHIV epidemicHIV-1Sustained transmissionMolecular epidemiologySubtypesPLHIVHIVG190SDifferent mutational pathwaysMutationsK101ED67NHigh levelsA62V
2022
Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth sectionProjected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study
Probert W, Sauter R, Pickles M, Cori A, Bell-Mandla N, Bwalya J, Abeler-Dörner L, Bock P, Donnell D, Floyd S, Macleod D, Piwowar-Manning E, Skalland T, Shanaube K, Wilson E, Yang B, Ayles H, Fidler S, Hayes R, Fraser C, Team H, Hayes R, Fidler S, Beyers N, Ayles H, Bock P, El-Sadr W, Cohen M, Eshleman S, Agyei Y, Piwowar-Manning E, Bond V, Hoddinott G, Donnell D, Floyd S, Wilson E, Emel L, Noble H, Macleod D, Burns D, Fraser C, Cori A, Sista N, Griffith S, Moore A, Headen T, White R, Miller E, Hargreaves J, Hauck K, Thomas R, Limbada M, Bwalya J, Pickles M, Sabapathy K, Schaap, Dunbar R, Shanaube K, Yang B, Simwinga M, Smith P, Vermund S, Mandla N, Makola N, van Deventer A, James A, Jennings K, Kruger J, Phiri M, Kosloff B, Mwenge L, Kanema S, Sauter R, Probert W, Kumar R, Sakala E, Silumesi A, Skalland T, Yuhas K. Projected outcomes of universal testing and treatment in a generalised HIV epidemic in Zambia and South Africa (the HPTN 071 [PopART] trial): a modelling study. The Lancet HIV 2022, 9: e771-e780. PMID: 36332654, PMCID: PMC9646978, DOI: 10.1016/s2352-3018(22)00259-4.Peer-Reviewed Original ResearchConceptsStandard of careHome-based testingCluster-randomised trialHigh-prevalence communitiesHIV incidenceHIV epidemicNational guidelinesNational InstituteUniversal testingHIV care cascadeAntiretroviral therapy uptakeUS President's Emergency PlanGeneralised HIV epidemicPresident's Emergency PlanPopART interventionCare cascadeART eligibilityArm BTherapy uptakeTrial interventionTrial dataInfectious diseasesAIDS ReliefIntervention impactDrug abuse
2020
Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials
Brault MA, Spiegelman D, Abdool Karim SS, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports 2020, 17: 249-258. PMID: 32297219, PMCID: PMC7260110, DOI: 10.1007/s11904-020-00492-4.Peer-Reviewed Original ResearchIncident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis.
Graybill LA, Kasaro M, Freeborn K, Walker JS, Poole C, Powers KA, Mollan KR, Rosenberg NE, Vermund SH, Mutale W, Chi BH. Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. AIDS 2020, 34: 761-776. PMID: 32167990, PMCID: PMC7275092, DOI: 10.1097/qad.0000000000002487.Peer-Reviewed Original ResearchConceptsBreast-feeding womenMaternal HIV incidenceHIV incidenceHIV acquisitionIncidence rateHIV preventionSystematic reviewHigh HIV incidencePartner's HIV statusHIV incidence ratesCombination HIV preventionNonpregnant periodsIncident HIVTreatment landscapeHIV statusSaharan AfricaElevated riskSummary estimatesRelevant conferencesIncidenceAverage incidenceLimited evidenceWomenCalendar timePreventionBuilding Partnerships and Stakeholder Relationships for HIV Prevention: Longitudinal Cohort Study Focuses on Community Engagement.
DeShields RD, Lucas JP, Turner M, Amola K, Hunter V, Lykes S, Rompalo AM, Vermund SH, Fischer S, Haley DF. Building Partnerships and Stakeholder Relationships for HIV Prevention: Longitudinal Cohort Study Focuses on Community Engagement. Progress In Community Health Partnerships Research Education And Action 2020, 14: 29-42. PMID: 32280121, PMCID: PMC7228022, DOI: 10.1353/cpr.2020.0006.Peer-Reviewed Original ResearchConceptsCommunity engagementAfrican American womenCommunity engagement frameworkHIV Prevention Trials Network 064Human immunodeficiency virus (HIV) burdenHIV incidence studyLongitudinal cohort studyAmerican womenHPTN 064Community organizationsNew partnershipsVenue-based samplingBuilding partnershipsCommunity stakeholdersEngagement approachStakeholder relationshipsResearch mistrustCohort studyCommunity partnersEngagement activitiesVirus burdenHIV incidenceHIV preventionHigh prevalenceEngagement framework
2019
Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaPredicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China
Zhang C, Webb GF, Lou J, Shepherd BE, Qian HZ, Liu Y, Vermund SH. Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China. AIDS Care 2019, 32: 343-353. PMID: 31619058, PMCID: PMC6981072, DOI: 10.1080/09540121.2019.1679704.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV incidenceHIV casesMale circumcisionSignificant public health impactHIV prevention interventionsPublic health impactCoverage ratePrevention interventionsNew infectionsEvidence baseMSMMenHealth impactsIncidenceCircumcisionLong-term impactFirst studyDifferent coverage ratesInfectionPrevalenceBaselineModeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China
Zhang C, Penson DF, Qian HZ, Webb GF, Lou J, Shephard BE, Liu Y, Vermund SH. Modeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China. International Journal Of STD & AIDS 2019, 30: 630-638. PMID: 30890118, PMCID: PMC6666307, DOI: 10.1177/0956462419831859.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV casesMale circumcisionHIV/AIDS epidemicCoverage rateHIV acquisitionHIV incidenceCumulative numberCircumcision ratesDeterministic compartmental modelEpidemiological impactVMMC implementationAIDS epidemicMenMSMCircumcisionSexYearsCompartmental modelCasesIncidence
2017
Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China
Lou J, Hu P, Qian HZ, Ruan Y, Jin Z, Xing H, Shao Y, Vermund SH. Expanded antiretroviral treatment, sexual networks, and condom use: Treatment as prevention unlikely to succeed without partner reduction among men who have sex with men in China. PLOS ONE 2017, 12: e0171295. PMID: 28406992, PMCID: PMC5390964, DOI: 10.1371/journal.pone.0171295.Peer-Reviewed Original ResearchConceptsCondom use increasesNew HIV infectionsMale sexual partnersPartner reductionCondom useSexual partnersHIV infectionBeijing MSMHIV new infectionsSexual behavioral changesAntiretroviral treatmentHIV testingHIV incidenceHIV prevalenceCombination interventionsSubstantial additional benefitNew infectionsUse increasesSexual networksInfectionMSMMenRisk reductionBehavioral changesTreatment
2014
Global HIV Epidemiology: A Guide for Strategies in Prevention and Care
Vermund SH. Global HIV Epidemiology: A Guide for Strategies in Prevention and Care. Current HIV/AIDS Reports 2014, 11: 93-98. PMID: 24691698, PMCID: PMC4042676, DOI: 10.1007/s11904-014-0208-x.Peer-Reviewed Original ResearchConceptsRisk populationsFemale sex worker cohortSex worker cohortPrevention of motherOpiate substitution therapyHIV prevention strategiesConsiderable clinical benefitPublic health approachRepresentative population sampleLow infectiousnessAntiretroviral therapyChild transmissionHIV incidenceClinical benefitSubstitution therapyConcentrated epidemicsHIV epidemicSentinel populationYoung MSMPrevalence surveyGeneralized epidemicsIncidence estimatesNeedle useEffective carePrevention servicesModeling the Impact on HIV Incidence of Combination Prevention Strategies among Men Who Have Sex with Men in Beijing, China
Lou J, Blevins M, Ruan Y, Vermund SH, Tang S, Webb GF, Shepherd BE, He X, Lu H, Shao Y, Qian HZ. Modeling the Impact on HIV Incidence of Combination Prevention Strategies among Men Who Have Sex with Men in Beijing, China. PLOS ONE 2014, 9: e90985. PMID: 24626165, PMCID: PMC3953201, DOI: 10.1371/journal.pone.0090985.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV epidemicCondom useHIV prevalenceART coverageCombination prevention strategiesHIV/AIDSHIV testingHIV incidenceCombination interventionsBeijing MSMPrevention strategiesPrevalence estimatesPrevalenceEpidemic expansionMenInterventionEpidemicIncidenceBasic reproduction numberPrevention scenariosCurrent coverageSexReproduction numberIntervention levelsHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm BHPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model
Cori A, Ayles H, Beyers N, Schaap A, Floyd S, Sabapathy K, Eaton JW, Hauck K, Smith P, Griffith S, Moore A, Donnell D, Vermund SH, Fidler S, Hayes R, Fraser C, . HPTN 071 (PopART): A Cluster-Randomized Trial of the Population Impact of an HIV Combination Prevention Intervention Including Universal Testing and Treatment: Mathematical Model. PLOS ONE 2014, 9: e84511. PMID: 24454728, PMCID: PMC3893126, DOI: 10.1371/journal.pone.0084511.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyArm AHIV incidenceHIV transmissionThree-arm cluster-randomized trialHIV combination prevention interventionsPopulation-level HIV incidenceCombination prevention interventionsCombination prevention packageHPTN 052 trialHPTN 071 (PopART) trialPopulation-level incidenceHIV-positive individualsHeterosexual HIV transmissionUptake of testingNational surveillance dataCluster-randomized trialImpact of treatmentLarge population clustersART retentionHPTN 071Primary endpointArm BPrevention packageControl arm
2013
High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless
Samo RN, Altaf A, Agha A, Pasha O, Rozi S, Memon A, Azam S, Blevins M, Vermund SH, Shah SA. High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless. PLOS ONE 2013, 8: e81715. PMID: 24358123, PMCID: PMC3864804, DOI: 10.1371/journal.pone.0081715.Peer-Reviewed Original ResearchConceptsIncidence of HIVHIV seroconversionIncidence rateMultivariable Cox regression analysisNeedle/syringe exchangeCohort of PWIDHIV-seronegative personsHigh HIV incidenceOpiate substitution therapyCox regression analysisHIV incidence ratesHIV risk reductionSharing of syringesRisk reductionSubstance abuse treatmentSeronegative personsCohort studyRisk reduction programsHIV incidencePerson yearsSubstitution therapyDaily injectionsNeedle sharingRisk factorsPrevalence ratesCan Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmission
2010
Sociocultural and epidemiological aspects of HIV/AIDS in Mozambique
Audet CM, Burlison J, Moon TD, Sidat M, Vergara AE, Vermund SH. Sociocultural and epidemiological aspects of HIV/AIDS in Mozambique. BMC Public Health 2010, 10: 15. PMID: 20529358, PMCID: PMC2891693, DOI: 10.1186/1472-698x-10-15.Peer-Reviewed Original ResearchHIV/AIDSHealth care infrastructureHIV incidenceHIV epidemicSevere health worker shortagesHuman immunodeficiency virus (HIV) epidemicAntenatal clinic sitesChronic disease servicesAIDS mortality ratesHealth system strengtheningHealth worker shortagesHealth care systemTerms HIVDrug adherenceImmunodeficiency syndromeMost HIVHeterosexual infectionHIV prevalenceDisease servicesClinic sitesEpidemiological aspectsGeneral populationMortality ratePrevalence estimatesHIV