1988
The design and implementation of a software system for clinical studies: An illustration based on the needs of a Comprehensive Cancer Center
Voynick I, Makuch R. The design and implementation of a software system for clinical studies: An illustration based on the needs of a Comprehensive Cancer Center. Journal Of Medical Systems 1988, 12: 295-304. PMID: 3230375, DOI: 10.1007/bf00996580.Peer-Reviewed Original ResearchConceptsRelational database management systemDatabase management systemData management needsClinical research databaseSoftware systemsProgramming featuresSystem securityProgramming methodologyData checkingManagement systemData entryMicrocomputer systemComputerized systemSoftwareArt technologiesDevelopment timeCommercial softwareTimely mannerNontechnical personnelSystem costAdditional system costsEffective approachHardwareUsersCheckingA prospective randomized trial of HLA‐matched versus mismatched single‐donor platelet transfusions in cancer patients
Messerschmidt G, Makuch R, Appelbaum F, Ungerleider R, Abrams R, O'Donnell J, Holohan T, Fontana J, Wright D, Anagnou N, Shan T, Chesbro B, Deisseroth A. A prospective randomized trial of HLA‐matched versus mismatched single‐donor platelet transfusions in cancer patients. Cancer 1988, 62: 795-801. PMID: 3293762, DOI: 10.1002/1097-0142(19880815)62:4<795::aid-cncr2820620426>3.0.co;2-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmbulatory CareAntibody FormationBlood DonorsBlood PlateletsBlood TransfusionChildChild, PreschoolClinical Trials as TopicFemaleHemorrhageHistocompatibility TestingHumansInfantMaleMiddle AgedNeoplasmsPlatelet TransfusionProspective StudiesRandom AllocationThrombocytopeniaTransfusion ReactionConceptsSingle-donor platelet transfusionsPlatelet transfusionsCancer patientsFebrile patientsPosttransfusion incrementsThrombocytopenic cancer patientsTransfusion of HLASevere bleeding episodesMulti-institution trialNonfebrile patientsIntensive chemotherapyBleeding episodesAntiplatelet antibodiesAntibody titersSignificant thrombocytopeniaHistocompatability antigensTransfusionPatientsMismatched groupHLAThrombocytopeniaPlateletsEpisodesSeparate episodesTrials
1984
Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience.
Tester W, Kinsella T, Waller B, Makuch R, Kelley P, Glatstein E, DeVita V. Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. Journal Of Clinical Oncology 1984, 2: 762-9. PMID: 6547479, DOI: 10.1200/jco.1984.2.7.762.Peer-Reviewed Original ResearchConceptsSecond malignant neoplasmsHodgkin's diseaseMalignant neoplasmsSolid tumorsNational Cancer Institute ExperienceChronic myeloid leukemiaCases of sarcomaRisk of leukemiaUntreated patientsPatient ageHodgkin's lymphomaMedical recordsInstitute experienceMyeloid leukemiaSimilar riskAge 40Treatment groupsPatientsGreater riskLeukemiaTen yearsDiseaseTumorsLymphomaPositive associationA non‐parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non‐responder bias
Simon R, Makuch R. A non‐parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non‐responder bias. Statistics In Medicine 1984, 3: 35-44. PMID: 6729287, DOI: 10.1002/sim.4780030106.Peer-Reviewed Original Research
1981
Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy
Von Hoff D, Casper J, Bradley E, Sandbach J, Jones D, Makuch R. Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy. The American Journal Of Medicine 1981, 70: 1027-1032. PMID: 7234870, DOI: 10.1016/0002-9343(81)90859-7.Peer-Reviewed Original ResearchConceptsIndividual patient's tumorPatient tumorsHuman tumorsGeneral oncology patientsParticular patient's tumorSeparate histologic typesProspective clinical trialsDrug sensitivity assaysColony-forming assaysHistologic typeOncology patientsClinical trialsPatient responsePatientsRetrospective mannerTumorsAntineoplastic agentsFluid specimenEnough cellsVivo resultsSensitivity assaysDrugsAssaysAssociationChemotherapy
1980
Serum glycoproteins in cancer patients: First report of correlations with in vitro and in vivo parameters of cellular immunity
Baskies A, Chretien P, Weiss J, Makuch R, Beveridge R, Catalona W, Spiegel H. Serum glycoproteins in cancer patients: First report of correlations with in vitro and in vivo parameters of cellular immunity. Cancer 1980, 45: 3050-3060. PMID: 7388749, DOI: 10.1002/1097-0142(19800615)45:12<3050::aid-cncr2820451229>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsDepressed cellular immunityLymphocyte reactivityCellular immunityCancer patientsAlpha 2 HS-glycoproteinAlbumin levelsTumor extentHS-glycoproteinVivo parametersLevels of haptoglobinLevels of APPSerum glycoprotein levelsSerum protein levelsSerum glycoproteinsOngoing trialsPreoperative patientsRegional tumorsSerum levelsImmune statusImmunologic functionSolid malignanciesNormal controlsPatientsGlycoprotein levelsPrimary site
1979
EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPY
Chretien P, Lipson S, Makuch R, Kenady D, Cohen M. EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPY. Annals Of The New York Academy Of Sciences 1979, 332: 135-147. PMID: 316979, DOI: 10.1111/j.1749-6632.1979.tb47107.x.Peer-Reviewed Original ResearchRecommendations for the analysis of the effect of treatment on the development of second malignancies
Makuch R, Simon R. Recommendations for the analysis of the effect of treatment on the development of second malignancies. Cancer 1979, 44: 250-253. PMID: 455251, DOI: 10.1002/1097-0142(197907)44:1<250::aid-cncr2820440141>3.0.co;2-1.Peer-Reviewed Original ResearchAbnormalities of Zinc and Copper During Total Parenteral Nutrition
LOWRY S, GOODGAME J, SMITH J, MAHER M, MAKUCH R, HENKIN R, BRENNAN M. Abnormalities of Zinc and Copper During Total Parenteral Nutrition. Annals Of Surgery 1979, 189: 120. PMID: 103506, PMCID: PMC1396940, DOI: 10.1097/00000658-197901000-00023.Peer-Reviewed Original ResearchConceptsParenteral nutritionSerum zincSerum levelsLimited oral intakeTotal parenteral nutritionMean serum zincNormal serum levelsSupplementation of zincCopper levelsPositive nitrogen retentionOral intakeUrinary outputBlood administrationUrinary nitrogen excretionHyperalimentation fluidsNormal limitsUrinary zincPatientsCopper excretionCopper intakeCopper supplementationExcretionNutritionIntakeSupplementation