1987
myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course.
Johnson B, Ihde D, Makuch R, Gazdar A, Carney D, Oie H, Russell E, Nau M, Minna J. myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. Journal Of Clinical Investigation 1987, 79: 1629-1634. PMID: 3034978, PMCID: PMC424486, DOI: 10.1172/jci112999.Peer-Reviewed Original ResearchConceptsMyc family DNA amplificationPatient tumorsTumor cell linesC-myc amplificationCell linesSmall cell lung cancer patientsCell lung cancer patientsSmall cell lung cancer cell linesCell lung cancer cell linesExtensive-stage patientsLung cancer patientsLung cancer cell linesCancer cell linesRelapsed patientsStage patientsClinical statusCancer patientsChemotherapy treatmentPatientsTumorsDNA amplificationOncogene amplification
1986
Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene.
Johnson B, Battey J, Linnoila I, Becker K, Makuch R, Snider R, Carney D, Minna J. Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. Journal Of Clinical Investigation 1986, 78: 525-532. PMID: 3016030, PMCID: PMC423589, DOI: 10.1172/jci112604.Peer-Reviewed Original ResearchConceptsSmall cell lung cancer cell linesCell lung cancer cell linesLung cancer cell linesCancer cell linesBombesin-like immunoreactivityLarge cell morphologyC-myc messenger RNAC-myc expressionC-MycCell linesSmall cell lung cancerHuman small cell lung cancer cell linesCell lung cancerSmall cell lung cancer linesCell lung cancer linesMessenger RNALung cancer linesC-myc amplificationC-myc geneLung cancerVariant phenotypesCloning efficiencyDecarboxylase levelsCancer linesBiologic properties