Periconceptional folic acid and neural tube defects: public health issues.
Pérez-Escamilla R. Periconceptional folic acid and neural tube defects: public health issues. Bulletin Of The Pan American Health Organization 1995, 29: 250-63. PMID: 8520610.Peer-Reviewed Original ResearchConceptsNeural tube defectsFolic acid supplementationPublic health issueAcid supplementationUnfavorable benefit/risk ratioPericonceptional folic acid intakeTube defectsBenefit/risk ratioRecurrent neural tube defectsHealth issuesFolic acidFolic acid intakePericonceptional folic acidDietary counselingPrimary preventionAcid intakeNTD pregnanciesRisk ratioProtective effectLow prevalenceFood fortificationMedical guidanceLow dosagePericonceptionSupplementation