Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants
Görk A, Ehrenkranz R, Bracken M. Continuous infusion versus intermittent bolus doses of indomethacin for patent ductus arteriosus closure in symptomatic preterm infants. Cochrane Database Of Systematic Reviews 2008, 2010: cd006071. PMID: 18254092, PMCID: PMC8912238, DOI: 10.1002/14651858.cd006071.pub2.Peer-Reviewed Original ResearchConceptsSymptomatic patent ductus arteriosusPatent ductus arteriosusTreatment of PDAContinuous indomethacin infusionRetinopathy of prematurityPDA closurePreterm infantsBolus administrationBolus injectionBlood flowBronchopulmonary dysplasiaIndomethacin infusionIntraventricular hemorrhagePremature infantsContinuous infusionMesenteric circulationRelative riskRisk differencePatent ductus arteriosus closureCerebral blood flow velocityAdverse effectsCochrane Neonatal reviewsContinuous infusion groupIntermittent bolus dosesSymptomatic preterm infants