2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2015
Confronting the missing epistasis problem: on the reproducibility of gene–gene interactions
Murk W, Bracken MB, DeWan AT. Confronting the missing epistasis problem: on the reproducibility of gene–gene interactions. Human Genetics 2015, 134: 837-849. PMID: 25998948, DOI: 10.1007/s00439-015-1564-3.Peer-Reviewed Original Research
2014
Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbationLongitudinal associations between asthma and general and abdominal weight status among Norwegian adolescents and young adults: the HUNT Study
Egan KB, Ettinger AS, DeWan AT, Holford TR, Holmen TL, Bracken MB. Longitudinal associations between asthma and general and abdominal weight status among Norwegian adolescents and young adults: the HUNT Study. Pediatric Obesity 2014, 10: 345-352. PMID: 25405952, DOI: 10.1111/ijpo.271.Peer-Reviewed Original ResearchConceptsRisk of asthmaWeight statusSelf-reported physician-diagnosed asthmaSubsequent weight statusPhysician-diagnosed asthmaBaseline weight statusPopulation-based surveyConsequences of obesityAsthmatic malesBaseline asthmaGeneral overweightAbdominal obesitySubsequent asthmaNormal weightObese adolescentsAsthma statusOverweight malesAdiposity associationsAsthmaAsthma associationsOverweightObesitySex stratificationBidirectional associationsAdiposityGeneral, but not abdominal, overweight increases odds of asthma among Norwegian adolescents: the Young‐HUNT study
Egan KB, Ettinger AS, DeWan AT, Holford TR, Holmen TL, Bracken MB. General, but not abdominal, overweight increases odds of asthma among Norwegian adolescents: the Young‐HUNT study. Acta Paediatrica 2014, 103: 1270-1276. PMID: 25131148, DOI: 10.1111/apa.12775.Peer-Reviewed Original ResearchConceptsPubertal development statusBody mass indexWaist circumferenceYoung-HUNT studyOdds ratioSelf-reported physician diagnosisOdds of asthmaAdjusted odds ratioPopulation-based studyConfidence intervalsPotential effect modifiersSelf-administered questionnaireYear old NorwegiansAbdominal obesityMass indexPhysician diagnosisIncrease oddsWeight statusAsthmaEffect modifiersNord-TrøndelagObesityOddsAdolescentsAssociation
2013
Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies
Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatrics 2013, 13: 121. PMID: 23941287, PMCID: PMC3751452, DOI: 10.1186/1471-2431-13-121.Peer-Reviewed Original ResearchConceptsBody mass indexCombined risk ratioProspective cohort studyRisk ratioYears of ageCohort studyMass indexChildhood body mass indexDescription of cohortPhysician-diagnosed asthmaNormal-weight childrenOverweight/obesityPotential effect modificationPotential effect modifiersIncident asthmaObesity definitionObserved sex effectsAsthma definitionsBMI assessmentObese childrenWeight childrenLanguage restrictionsSubgroup analysisObesity prevalenceEffect modificationMaternal Infection in Pregnancy and Risk of Asthma in Offspring
Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal Infection in Pregnancy and Risk of Asthma in Offspring. Maternal And Child Health Journal 2013, 17: 1940-1950. PMID: 23338127, DOI: 10.1007/s10995-013-1220-2.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRisk of asthmaChildhood asthmaMaternal infectionTract infectionsMaternal urinary tract infectionMultivariable logistic regression modelAdjusted odds ratioChildren of womenYears of lifeLogistic regression modelsAntepartum infectionChart reviewPhysician diagnosisPregnant womenStreptococcus colonizationHospital visitsOdds ratioAsthmaPregnancyInfectionWomenRiskStructured interviewsAge six
2010
PDE11A associations with asthma: Results of a genome-wide association scan
DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O’Connor G, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: Results of a genome-wide association scan. Journal Of Allergy And Clinical Immunology 2010, 126: 871-873.e9. PMID: 20920776, PMCID: PMC3133448, DOI: 10.1016/j.jaci.2010.06.051.Peer-Reviewed Original Research
2001
Use of Health Services by Insurance Status Among Children With Asthma
Ortega A, Belanger K, Paltiel A, Horwitz S, Bracken M, Leaderer B. Use of Health Services by Insurance Status Among Children With Asthma. Medical Care 2001, 39: 1065-1074. PMID: 11567169, DOI: 10.1097/00005650-200110000-00004.Peer-Reviewed Original ResearchConceptsPrimary care visitsHealth care useEmergency departmentInsurance statusCare visitsAsthmatic childrenMedication useCare useAsthma-related risk factorsRoutine primary care visitsProspective cohort studyHealth care visitsHealth care utilizationChildhood asthma severityPatient-provider communicationWhite childrenMedical DictionaryNew England hospitalsRace/ethnicityAsthma specialistCohort studyMedicaid childrenAsthma severityIndependent predictorsCare utilizationThe relation between fungal propagules in indoor air and home characteristics
Ren P, Jankun T, Belanger K, Bracken M, Leaderer B. The relation between fungal propagules in indoor air and home characteristics. Allergy 2001, 56: 419-424. PMID: 11350305, DOI: 10.1034/j.1398-9995.2001.056005419.x.Peer-Reviewed Original ResearchMeSH KeywordsAir MicrobiologyAir Pollution, IndoorAnimalsAnimals, DomesticAsthmaCatsEnvironmental MonitoringEpidemiological MonitoringFamily CharacteristicsFungiHeatingHousingHumansHumidityIncomeInfantNew EnglandPredictive Value of TestsProspective StudiesSeasonsSurveys and QuestionnairesTime FactorsVentilationConceptsCFU/m3 airInfants' bedroomsMain living areaProspective cohort studyDevelopment of asthmaHome characteristicsAnnual household incomeAllergen exposureCohort studyEpidemiologic studiesM3 airPresence of petsExposure levelsExposure assessmentSignificant differencesBurkard portable air samplerLiving areasQuestionnaireIndoor airFungal exposure assessmentHouse characteristicsHousehold incomeHomeDG-18AsthmaA childhood asthma severity scale: symptoms, medications, and health care visits
Ortega A, Belanger K, Bracken M, Leaderer B. A childhood asthma severity scale: symptoms, medications, and health care visits. Annals Of Allergy Asthma & Immunology 2001, 86: 405-413. PMID: 11345283, DOI: 10.1016/s1081-1206(10)62486-6.Peer-Reviewed Original ResearchConceptsHealth care visitsChildhood asthma severityCare visitsAsthma severityLarge-scale epidemiologic studiesAsthma severity scaleMedication useSeverity ScaleEpidemiologic studiesHome interviewsProspective cohort studyHealth care utilizationCohort studyAsthmatic childrenCare utilizationDaily symptomsInsurance statusConnecticut hospitalsGeneral populationClinimetric propertiesClinimetric validityMaternal educationClinical diagnosisParticipant characteristicsSymptoms
1993
Possible Role of Asthma in the Risk of Preterm Labor and Delivery
Doucette J, Bracken M. Possible Role of Asthma in the Risk of Preterm Labor and Delivery. Epidemiology 1993, 4: 143-150. PMID: 8452903, DOI: 10.1097/00001648-199303000-00010.Peer-Reviewed Original ResearchConceptsPreterm laborPreterm deliveryRespiratory problemsOdds ratioHistory of asthmaLogistic regression modelsAsthmatic womenSingleton livebirthsPotential confoundersMaternal historyMedical historyHigh riskStudy participantsAsthmaPregnancyAsthmaticsWomenRiskPossible roleRegression modelsOddsDeliveryNonasthmaticsBirthweightLivebirths