2009
P9. Age as a Key Determinant of Mortality, Impairment and Disability Following Traumatic Spinal Cord Injury: Analysis of the NASCIS-3 Database
Furlan J, Bracken M, Fehlings M. P9. Age as a Key Determinant of Mortality, Impairment and Disability Following Traumatic Spinal Cord Injury: Analysis of the NASCIS-3 Database. The Spine Journal 2009, 9: 118s. DOI: 10.1016/j.spinee.2009.08.267.Peer-Reviewed Original Research
2008
Article 6: Functional Recovery in the Geriatric Population Following Acute Traumatic Spinal Cord Injury: Analysis of the Third National Acute Spinal Cord Injury Study Database
Furlan J, Bracken M, Fehlings M. Article 6: Functional Recovery in the Geriatric Population Following Acute Traumatic Spinal Cord Injury: Analysis of the Third National Acute Spinal Cord Injury Study Database. Archives Of Physical Medicine And Rehabilitation 2008, 89: e2. DOI: 10.1016/j.apmr.2008.08.014.Peer-Reviewed Original Research202. Assessment of Age as Key Determinant of Mortality and Neurological Outcome after Acute Traumatic Spinal Cord Injury: Analysis of the NASCIS-2 Database
Furlan J, Bracken M, Fehlings M. 202. Assessment of Age as Key Determinant of Mortality and Neurological Outcome after Acute Traumatic Spinal Cord Injury: Analysis of the NASCIS-2 Database. The Spine Journal 2008, 8: 101s. DOI: 10.1016/j.spinee.2008.06.241.Peer-Reviewed Original Research
2007
The Impact of Age at The Time of Injury on the Mortality and Neurological Outcome After Acute Traumatic Spinal Cord Injury: Examination of the NASCIS-2 Database
Furlan J, Bracken M, Fehlings M. The Impact of Age at The Time of Injury on the Mortality and Neurological Outcome After Acute Traumatic Spinal Cord Injury: Examination of the NASCIS-2 Database. Spine: Affiliated Society Meeting Abstracts 2007, &NA;: 19-20. DOI: 10.1097/01.brs.0000317716.47139.aa.Peer-Reviewed Original Research
2001
Methylprednisolone and Acute Spinal Cord Injury
Bracken M. Methylprednisolone and Acute Spinal Cord Injury. Spine 2001, 26: s47-s54. PMID: 11805609, DOI: 10.1097/00007632-200112151-00010.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryMethodologic qualitySystematic reviewImproved functional recoveryHigh methodologic qualityNeurologic recoveryClinical recoveryPharmacologic therapyFunctional recoveryRandomized trialsInjury trialsCochrane LibraryEffective therapySurgical trialsEarly treatmentFurther trialsTherapeutic interventionsInjuryMeSH headingsMethylprednisoloneScore improvementPatientsEvidence base
2000
Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury
Bracken M, Aldrich E, Herr D, Hitchon P, Holford T, Marshall L, Nockels R, Pascale V, Shepard M, Sonntag V, Winn H, Young W. Clinical Measurement, Statistical Analysis, and Risk-Benefit: Controversies from Trials of Spinal Injury. Journal Of Trauma And Acute Care Surgery 2000, 48: 558-561. PMID: 10744306, DOI: 10.1097/00005373-200003000-00036.Commentaries, Editorials and LettersConceptsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyClinical measurementsHigh-dose methylprednisoloneSecondary neuronal damageSpinal cord injuryRisk benefitNeuronal damageFunctional recoverySafety profileCord injuryPharmacologic agentsSpinal injuryInjury studiesInnovative therapiesTrialsStatistical analysisInjuryMulticenterMethylprednisoloneSeries of trialsTherapyPrevention
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareAdministration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury
BRACKEN M, SHEPARD M, HOLFORD T, LEO-SUMMERS L, ALDRICH E, FAZL M, FEHLINGS M, HERR D, HITCHON P, MARSHALL L, NOCKELS R, PASCALE V, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H, YOUNG W. Administration of Methylprednisolone for 24 or 48 Hours or Tirilazad Mesylate for 48 Hours in the Treatment of Acute Spinal Cord Injury. Survey Of Anesthesiology 1998, 42: 197. DOI: 10.1097/00132586-199808000-00011.Peer-Reviewed Original Research
1994
The Effectiveness of Surgery on the Treatment of Acute Spinal Cord Injury and Its Relation to Pharmacological Treatment
Duh M, Shepard M, Wilberger J, Bracken M. The Effectiveness of Surgery on the Treatment of Acute Spinal Cord Injury and Its Relation to Pharmacological Treatment. Neurosurgery 1994, 35: 240???249. DOI: 10.1097/00006123-199408000-00009.Peer-Reviewed Original ResearchThe effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2
Shepard M, Bracken M. The effect of methylprednisolone, naloxone, and spinal cord trauma on four liver enzymes: observations from NASCIS 2. Spinal Cord 1994, 32: 236-245. PMID: 8022633, DOI: 10.1038/sc.1994.43.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryLiver enzymesDrug protocolsNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyStudy drug infusionEnzyme levelsLiver enzyme levelsEffect of methylprednisoloneSpinal cord traumaDays post infusionSeverity of injuryTotal bilirubin testsSteroid protocolCord traumaLiver functionSpinal cordDrug infusionPost infusionInjury studiesLarge dosesBilirubin testInjury
1993
Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2.
Bracken M, Holford T. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. Journal Of Neurosurgery 1993, 79: 500-7. PMID: 8410217, DOI: 10.3171/jns.1993.79.4.0500.Peer-Reviewed Original ResearchConceptsNational Acute Spinal Cord Injury StudyNeurological recoveryIncomplete injuriesNeurological functionNaloxone administrationClinical managementAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneLong spinal tractsHours of injuryUltimate therapeutic goalInjury levelConsiderable clinical significanceNarrow treatment windowMethylprednisolone treatmentSpinal tractClinical significanceSegmental functionInjury studiesTherapeutic goalsTreatment windowMethylprednisoloneHigh dosesInjuryPharmacological treatment of acute spinal cord injury: current status and future projects.
Bracken M. Pharmacological treatment of acute spinal cord injury: current status and future projects. Journal Of Emergency Medicine 1993, 11 Suppl 1: 43-8. PMID: 8445202.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injurySecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyEffectiveness of methylprednisoloneMethylprednisolone-treated patientsRecovery of motorHours of injuryLevel of injuryMethylprednisolone groupPinprick sensationTirilazad mesylateMethylprednisolone infusionGlucocorticoid activityInitial bolusNeurological functionPharmacological treatmentMotor functionSpinal cordInjury studiesSensory functionInjury
1992
Pharmacological treatment of acute spinal cord injury: current status and future prospects
Bracken M. Pharmacological treatment of acute spinal cord injury: current status and future prospects. Spinal Cord 1992, 30: 102-107. PMID: 1589282, DOI: 10.1038/sc.1992.34.Peer-Reviewed Original ResearchA model for estimating level and net severity of spinal cord injuries
Holford T, Bracken M. A model for estimating level and net severity of spinal cord injuries. Statistics In Medicine 1992, 11: 1171-1186. PMID: 1509218, DOI: 10.1002/sim.4780110904.Peer-Reviewed Case Reports and Technical NotesConceptsSpinal cord injuryCord injuryNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudyAcute spinal cord injurySpinal Cord Injury StudyDetailed neurological assessmentNeurologic functionNeurological assessmentMotor assessmentInjury studiesOverall severityInjurySeverityScoresLevelsEpidemiology
1991
Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial.
Bracken M. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. Journal Of Neurotrauma 1991, 8 Suppl 1: s47-50; discussion s51-2. PMID: 1920461.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryAdministration of methylprednisoloneApparent contraindicationsNeurological improvementClinical trialsPermanent paralysisMethylprednisoloneLow dosesInjuryAdministrationDosesTrialsTreatmentMulticenterPlaceboContraindicationsNaloxoneParalysisDoseA Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
BRACKEN M, SHEPARD M, COLLINS W, HOLFORD T, YOUNG W, BASKIN D, EISENBERG H, FLAMM E, LEOSUMMERS L, MAROON J, MARSHALL L, PEROT P, PIEPMEIER J, SONNTAG V, WAGNER F, WILBERGER J, WINN H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. Survey Of Anesthesiology 1991, 35: 50. DOI: 10.1097/00132586-199102000-00048.Peer-Reviewed Original Research
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1985
Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Hellenbrand K, Collins W, Leo L, Freeman D, Wagner F, Flamm E, Eisenberg H, Goodman J, Perot P, Green B, Grossman R, Meagher J, Young W, Fischer B, Clifton G, Hunt W, Rifkinson N. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1985, 63: 704-13. PMID: 3903070, DOI: 10.3171/jns.1985.63.5.0704.Peer-Reviewed Original ResearchConceptsTotal steroid doseNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneSteroid treatment protocolFunction 1 yearCase fatality rateSpinal cord injuryPinprick responseSteroid doseNeurological recoveryCord injuryStandard dosePatient genderClinical trialsMotor functionTreatment protocolStudy groupInjury studiesTreatment groupsFatality rateInjuryMethylprednisoloneTreatment effects
1984
Efficacy of Methylprednisolone in Acute Spinal Cord Injury
Bracken M, Collins W, Freeman D, Shepard M, Wagner F, Silten R, Hellenbrand K, Ransohoff J, Hunt W, Perot P, Grossman R, Green B, Eisenberg H, Rifkinson N, Goodman J, Meagher J, Fischer B, Clifton G, Flamm E, Rawe S. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA 1984, 251: 45-52. PMID: 6361287, DOI: 10.1001/jama.1984.03340250025015.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryEarly case fatalityEfficacy of methylprednisoloneHigh-dose regimenLight touch sensationHigh-dose protocolGroups six weeksNeurological recoveryCase fatalityWound infectionStandard doseMotor functionInitial lesionHigh doseOperative siteSix weeksInjuryMethylprednisoloneTreatment effectsTouch sensationDoseEfficacyMulticenter