2024
Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study
Hoobler R, Puklin L, Harrigan M, Cartmel B, Li F, Sanft T, Ferrucci L, Irwin M, Playdon M. Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study. Journal Of Cancer Survivorship 2024, 1-9. PMID: 39528779, DOI: 10.1007/s11764-024-01702-3.Peer-Reviewed Original ResearchBreast cancer survivorsClinically meaningful weight lossCancer survivorsWeight loss interventionCancer SurvivorsBreast cancer survivorsWeight loss successConclusionBreast cancer survivorsPrevention of weight gainAssociated with lower oddsHistory of weight gainHealthy body weightMultivariate logistic regressionCancer treatmentSuccessful weight lossBreast cancer treatmentIntervention armLower oddsResultsBaseline dataDesign of programsWeight lossLogistic regressionC-statisticWeight gainSurvivorsIntervention
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight management
2021
Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth records
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2012
Post diagnosis weight gain and the role of exercise in breast cancer survivors.
Sanft T, Alvarez-Reeves M, Irwin M. Post diagnosis weight gain and the role of exercise in breast cancer survivors. Journal Of Clinical Oncology 2012, 30: 9007-9007. DOI: 10.1200/jco.2012.30.15_suppl.9007.Peer-Reviewed Original ResearchBone mineral densityLean body massDual-energy X-ray absorptiometryBreast cancer survivorsUsual careCA survivorsObese womenCancer survivorsBody fatBody compositionPoor breast cancer outcomesWeight gainFavorable body composition changesNon-obese womenBreast cancer outcomesRole of exerciseEffects of exerciseMin/wkPhysical activity levelsBody composition changesX-ray absorptiometrySupervised exerciseExercise groupExercise interventionUC group
2011
Obesity and Cancer: Epidemiology
Irwin M. Obesity and Cancer: Epidemiology. Energy Balance And Cancer 2011, 1: 101-110. DOI: 10.1007/978-1-4419-9911-5_4.Peer-Reviewed Original ResearchA review of web‐based weight loss interventions in adults
Arem H, Irwin M. A review of web‐based weight loss interventions in adults. Obesity Reviews 2011, 12: e236-e243. PMID: 20804523, PMCID: PMC3086798, DOI: 10.1111/j.1467-789x.2010.00787.x.Peer-Reviewed Original ResearchConceptsWeight lossWeb-based weight loss interventionObesity-related health complicationsWeight loss interventionBurden of diseasePublic health practitionersInternet-delivered interventionsAssociated health consequencesLoss interventionLow adherenceHealthcare costsEfficacious interventionsHealth complicationsObesity ratesControl groupNon-Caucasian participantsHealth consequencesWeight gainHealth practitionersIntervention resultsDefinitive conclusionsPopulation-specific researchPeer-reviewed literatureInterventionMore males
2008
Impact of Nutrition and Exercise on Cancer Survival
Irwin ML, Mayne ST. Impact of Nutrition and Exercise on Cancer Survival. The Cancer Journal 2008, 14: 435-441. PMID: 19060611, DOI: 10.1097/ppo.0b013e31818daeee.Peer-Reviewed Original ResearchConceptsCancer survivorsSupplement useCancer survivalAdverse prognostic factorPhysical activity recommendationsNutrient supplement useAmerican Cancer SocietyLifestyle-based approachLong-term survivalImpact of nutritionLifestyle interventionPrognostic factorsRandomized trialsCancer outcomesPhysical inactivityActivity recommendationsCurrent guidelinesNumber of menCancer SocietyPhysical activityWeight gainAvailable evidenceSurvivorsSurvivalObesity
2004
Physical activity levels among breast cancer survivors.
Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Physical activity levels among breast cancer survivors. Medicine & Science In Sports & Exercise 2004, 36: 1484-91. PMID: 15354027, PMCID: PMC3000611.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsHispanic breast cancer survivorsLevel of PACancer survivorsPhysical activityWeight gainBlack breast cancer survivorsObese breast cancer survivorsSurveillance Epidemiology End ResultsPostdiagnosis weight gainNegative prognostic factorBreast cancer survivalRecreational physical activityPhysical activity levelsGeneral adult populationBreast cancer prognosisNon-Hispanic whitesCategories of adiposityPrognostic factorsType of sportDisease stageCancer survivalLifestyle StudyBreast cancerPA recommendations
2003
Physical activity levels before and after a diagnosis of breast carcinoma
Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard‐Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma. Cancer 2003, 97: 1746-1757. PMID: 12655532, PMCID: PMC3034406, DOI: 10.1002/cncr.11227.Peer-Reviewed Original ResearchConceptsBody mass indexPhysical activityBreast carcinomaIncident breast carcinomaPopulation-based studyRisk of recurrenceTotal physical activitySport physical activityPrediagnosis levelsAdjuvant treatmentPatient ageMass indexType of sportAdverse outcomesDisease stageTime patientsBaseline interviewBody weightPA levelsWeight gainPatientsDiagnosisCarcinomaWomenChemotherapy