2008
LOT: a tool for linkage analysis of ordinal traits for pedigree data
Zhang M, Feng R, Chen X, Hu B, Zhang H. LOT: a tool for linkage analysis of ordinal traits for pedigree data. Bioinformatics 2008, 24: 1737-1739. PMID: 18535081, PMCID: PMC2566542, DOI: 10.1093/bioinformatics/btn258.Peer-Reviewed Original Research
2007
A forest-based approach to identifying gene and gene–gene interactions
Chen X, Liu CT, Zhang M, Zhang H. A forest-based approach to identifying gene and gene–gene interactions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19199-19203. PMID: 18048322, PMCID: PMC2148267, DOI: 10.1073/pnas.0709868104.Peer-Reviewed Original ResearchA score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research
2006
Family‐based association tests for ordinal traits adjusting for covariates
Wang X, Ye Y, Zhang H. Family‐based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology 2006, 30: 728-736. PMID: 17086513, DOI: 10.1002/gepi.20184.Peer-Reviewed Original ResearchLinkage analysis of longitudinal data and design consideration
Zhang H, Zhong X. Linkage analysis of longitudinal data and design consideration. BMC Genomic Data 2006, 7: 37. PMID: 16768806, PMCID: PMC1550417, DOI: 10.1186/1471-2156-7-37.Peer-Reviewed Original ResearchAscertainment adjustment in genetic studies of ordinal traits
Feng R, Zhang H. Ascertainment adjustment in genetic studies of ordinal traits. Human Genetics 2006, 119: 429-435. PMID: 16528520, DOI: 10.1007/s00439-006-0147-8.Peer-Reviewed Original ResearchDetection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies
Zhang H, Wang X, Ye Y. Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies. Genetics 2006, 172: 693-699. PMID: 16219774, PMCID: PMC1456175, DOI: 10.1534/genetics.105.049122.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsQuantitative traitsOrdinal traitsTraditional linkage studiesGenomewide association analysisAssociation of genesDetection of genesGametic disequilibriumLoci existAssociation studiesAssociation analysisGenesLinkage disequilibriumTraitsComplex diseasesLinkage studiesGrowth-associated protein 43Protein 43DisequilibriumPolymorphismFamilyMarkersNuclear families
2005
Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
Zhong X, Zhang H. Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data. BMC Genomic Data 2005, 6: s31. PMID: 16451641, PMCID: PMC1866754, DOI: 10.1186/1471-2156-6-s1-s31.Peer-Reviewed Original ResearchConceptsLinkage analysisAssociation analysisSusceptibility genesGenetic Analysis Workshop 14Alcoholism dataCombination of linkageComplex disease mappingDisease susceptibility genesEntire genomeMean identityLinkage disequilibriumTransmission/disequilibrium testAssociation TestGenesPresence of linkageDisequilibrium testGenomeChromosomesGeneticsLinkageDisequilibriumAssociation strategyGreater numberRegion
2004
Linkage analysis of ordinal traits for pedigree data
Feng R, Leckman JF, Zhang H. Linkage analysis of ordinal traits for pedigree data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16739-16744. PMID: 15548606, PMCID: PMC534720, DOI: 10.1073/pnas.0404623101.Peer-Reviewed Original ResearchConceptsLinkage analysisOrdinal traitsTourette Syndrome Association International ConsortiumLinkage analysis methodsQuantitative traitsEvidence of linkageGenome scanLinkage scanHuman diseasesAllele sharingTraitsPedigree dataInheritance patternDichotomous traitsSignificant allele sharingPhenotypeProportional odds logistic modelGENEHUNTERGenesGeneticsMarkersInternational ConsortiumResults of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.Peer-Reviewed Original Research
2002
Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome
Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR, Genetics T. Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome. American Journal Of Human Genetics 2002, 70: 896-904. PMID: 11840360, PMCID: PMC379118, DOI: 10.1086/339520.Peer-Reviewed Original ResearchAllelesBehavioral SymptomsChromosomes, HumanChromosomes, Human, Pair 17Chromosomes, Human, Pair 4Chromosomes, Human, Pair 5Gene FrequencyGenetic LinkageGenetic MarkersGenome, HumanHumansMatched-Pair AnalysisNuclear FamilyObsessive-Compulsive DisorderPhenotypeQuantitative Trait, HeritableSoftwareStatistics, NonparametricTourette Syndrome
2000
Use of classification trees for association studies
Zhang H, Bonney G. Use of classification trees for association studies. Genetic Epidemiology 2000, 19: 323-332. PMID: 11108642, DOI: 10.1002/1098-2272(200012)19:4<323::aid-gepi4>3.0.co;2-5.Peer-Reviewed Original Research
1997
Cost-effective sib-pair designs in the mapping of quantitative-trait loci.
Zhao H, Zhang H, Rotter JI. Cost-effective sib-pair designs in the mapping of quantitative-trait loci. American Journal Of Human Genetics 1997, 60: 1211-21. PMID: 9150169, PMCID: PMC1712450.Peer-Reviewed Original Research
1996
Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes.
Zhang H, Risch N. Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. American Journal Of Human Genetics 1996, 59: 951-7. PMID: 8808613, PMCID: PMC1914798.Peer-Reviewed Original ResearchMapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.
Risch N, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. American Journal Of Human Genetics 1996, 58: 836-43. PMID: 8644748, PMCID: PMC1914664.Peer-Reviewed Original Research
1995
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
Risch N, Zhang H. Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans. Science 1995, 268: 1584-1589. PMID: 7777857, DOI: 10.1126/science.7777857.Peer-Reviewed Original Research