2018
Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation
Barnhart K, Giudice L, Young S, Thomas T, Diamond MP, Segars J, Youssef WA, Krawetz S, Santoro N, Eisenberg E, Zhang H, Network F. Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation. Contemporary Clinical Trials 2018, 68: 1-6. PMID: 29524590, PMCID: PMC5899676, DOI: 10.1016/j.cct.2018.03.002.Peer-Reviewed Original ResearchConceptsReproductive Medicine NetworkDisease-specific questionnaireReproductive-aged womenTime of surgeryEstrogen-dependent conditionStage of endometriosisExtensive clinical evaluationSeverity of diseaseNoninvasive diagnostic biomarkersAcademic medical centerPelvic painEndometrial biopsyNonsurgical diagnosisSerum cytokinesSurgical ablationGynecologic surgeryClinical evaluationClinical reasonsMedical CenterAged womenPharmacological controlEndometriosisGenomic classifierSpecific questionnaireTherapy shifts
2005
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome
Leckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.Peer-Reviewed Original ResearchConceptsEarly-onset obsessive-compulsive disorderObsessive-compulsive disorderSymptom exacerbationInterleukin-12Control subjectsImmune responseTourette syndromeTumor necrosis factor-alpha concentrationsNecrosis factor-alpha concentrationsAge-matched control subjectsInvolvement of innateLocal cytokine synthesisT cell immunityHumoral immune responseCentral nervous systemInnate immune responseLongitudinal studyProspective longitudinal studyT cell activationCell immunitySerum levelsPediatric populationCommon infectionsSerum concentrationsInflammatory process