2019
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis
Wang R, Li W, Bordewijk E, Legro R, Zhang H, Wu X, Gao J, Morin-Papunen L, Homburg R, König T, Moll E, Kar S, Huang W, Johnson N, Amer S, Vegetti W, Palomba S, Falbo A, Özmen Ü, Nazik H, Williams C, Federica G, Lord J, Sahin Y, Bhattacharya S, Norman R, van Wely M, Mol B, Network+ R, Collaboration T. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Human Reproduction Update 2019, 25: 717-732. PMID: 31647106, DOI: 10.1093/humupd/dmz029.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical pregnancy rateClomiphene citrateLive birth rateOvulation inductionTime-to-pregnancyAnovulatory infertilityFrequent cause of anovulatory infertilityPregnancy rateCause of anovulatory infertilityBirth rateMetformin to CCOvulation induction agentsIncreased clinical pregnancyLive birthsPrimary randomised controlled trialsClinical pregnancyRandomised controlled trialsInfertilityIndividual participant dataIPD meta-analysesWomenPositive interactionsLetrozoleAccurate assessment of outcomes
2014
Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype
Legro RS, Chen G, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Foulds J, Barnhart K, Martino L, Timbers K, Lambe L, DeWire R, Yang H, Bodine C, Mark D, Puscheck E, Ginsburg K, Collins K, Brossoit M, Leach R, Yelian F, Perez M, Buster J, Amato P, Torres M, Dodson W, Gnatuk C, Ober J, Demers L, Heller D, Colon J, Weiss G, Solnica A, Gatlin K, Hahn S, Roark M, Blackwell R, Willis V, Love L, Laychak K, Nazmy M, Stovall D, Evans W, Turner K, Chang J, Malcolm P, Coddington C, Permanente K, Faber K, Hasenleider D, Huang H. Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype. Human Reproduction 2014, 29: 2680-2686. PMID: 25324541, PMCID: PMC4227579, DOI: 10.1093/humrep/deu239.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeSerum cotinine levelsCase-control studySmoking statusInfertility treatmentCotinine levelsPast smokersCurrent smokersOvary syndromeInfertile womenInsulin resistanceFirst-line ovulation induction agentsMulti-center clinical trialOvulation induction agentsWorse insulin resistanceTotal testosterone levelsLive birth rateSecond-hand smokePARTICIPANTS/MATERIALSNational InstituteROLE OF CHANCESelf-reported changesHirsutism scoreSmoking groupRecent smokers