2018
Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence
Zhang H, Liu D, Zhao J, Bi X. Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence. The Annals Of Applied Statistics 2018, 12: 2359-2378. PMID: 30666272, PMCID: PMC6338437, DOI: 10.1214/18-aoas1156.Peer-Reviewed Original ResearchFull likelihoodComplicated likelihood functionsParametric frameworkParametric modeling frameworkHigh computational complexityExtensive simulation studyModel fitting algorithmStatistical inferenceRank-based methodLikelihood functionComputational burdenType I error ratesComputational complexityFitting algorithmSimulation studyNovel multivariate modelModeling frameworkEffect size estimationLatent variablesHybrid modelInferenceSize estimationModelFrameworkTheory
2016
The screening and ranking algorithm for change-points detection in multiple samples
Song C, Min X, Zhang H. The screening and ranking algorithm for change-points detection in multiple samples. The Annals Of Applied Statistics 2016, 10: 2102-2129. PMID: 28090239, PMCID: PMC5233178, DOI: 10.1214/16-aoas966.Peer-Reviewed Original ResearchChange-point detectionExtensive simulation studyScan statisticNumber statesPrimary open-angle glaucoma genesEnergy bagging tree.
Cao T, Wang X, Zhang H. Energy bagging tree. Statistics And Its Interface 2016, 9: 171-181. PMID: 26594301, PMCID: PMC4648255, DOI: 10.4310/sii.2016.v9.n2.a5.Peer-Reviewed Original ResearchMeasures of dispersionMultivariate nonparametric regression problemReal data analysisNonparametric regression problemsGini’s mean differenceNon-parametric extensionExtensive simulation studyRegression problemsSimulation studyEnergy distanceComplex dataBagging treesRegression tree methodTree methodSample variationData analysisDispersion
2015
Association Tests of Multiple Phenotypes: ATeMP
Guo X, Li Y, Ding X, He M, Wang X, Zhang H. Association Tests of Multiple Phenotypes: ATeMP. PLOS ONE 2015, 10: e0140348. PMID: 26479245, PMCID: PMC4610695, DOI: 10.1371/journal.pone.0140348.Peer-Reviewed Original ResearchConceptsExtensive simulation studyStatistical literatureJoint association analysisMultiPhenSimulation studyEquivalence relationshipProportional odds modelReal case studyMeasurement errorMultivariate methodsOdds modelMultiple intermediate phenotypesJoint analysisMultiple phenotypesExplanatory variablesEquivalenceEstimationDistributionPhenotypic distributionATempSolutionError