Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data
Tang H, Wei P, Duell EJ, Risch HA, Olson SH, Bueno-de-Mesquita HB, Gallinger S, Holly EA, Petersen G, Bracci PM, McWilliams RR, Jenab M, Riboli E, Tjønneland A, Boutron-Ruault MC, Kaaks R, Trichopoulos D, Panico S, Sund M, Peeters PH, Khaw KT, Amos CI, Li D. Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. Carcinogenesis 2014, 35: 1039-1045. PMID: 24419231, PMCID: PMC4004205, DOI: 10.1093/carcin/bgu010.Peer-Reviewed Original ResearchConceptsIngenuity Pathway AnalysisKEGG pathwaysSingle nucleotide polymorphism (SNP) levelAxonal guidanceGenome-wide levelGene ontology pathwaysSalivary secretion pathwaysSlit/RoboGenes/SNPsOntology pathwaysPolymorphism levelSecretion pathwayGWAS dataGene setsPancreatic Cancer Case-Control ConsortiumCanonical pathwaysPathway analysisAxon guidanceGenesSNPsRegion SNPsPathwayIPA analysisPancreatic cancerDiscovery studiesGenes–Environment Interactions in Obesity- and Diabetes-Associated Pancreatic Cancer: A GWAS Data Analysis
Tang H, Wei P, Duell EJ, Risch HA, Olson SH, Bueno-de-Mesquita HB, Gallinger S, Holly EA, Petersen GM, Bracci PM, McWilliams RR, Jenab M, Riboli E, Tjønneland A, Boutron-Ruault MC, Kaaks R, Trichopoulos D, Panico S, Sund M, Peeters PH, Khaw KT, Amos CI, Li D. Genes–Environment Interactions in Obesity- and Diabetes-Associated Pancreatic Cancer: A GWAS Data Analysis. Cancer Epidemiology Biomarkers & Prevention 2014, 23: 98-106. PMID: 24136929, PMCID: PMC3947145, DOI: 10.1158/1055-9965.epi-13-0437-t.Peer-Reviewed Original ResearchConceptsPancreatic cancerIngenuity Pathway AnalysisSingle nucleotide polymorphismsAssociation of obesityPancreatic Cancer Case-Control ConsortiumRisk of obesityAlterable risk factorsPancreatic cancer riskRisk factor dataLogistic regression modelsGenome-wide levelAdditional large datasetsMajor contributing genesInsulin resistanceRisk factorsInflammatory responseCancer riskGene-environment interactionsObesityGene-environment interaction analysisSignificant interactionDiabetesGWAS data analysisCancerGenetic susceptibility