2015
Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis
Schulte A, Pandeya N, Fawcett J, Fritschi L, Risch HA, Webb PM, Whiteman DC, Neale RE. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes & Control 2015, 26: 1027-1035. PMID: 25951801, DOI: 10.1007/s10552-015-0595-3.Peer-Reviewed Original ResearchConceptsH. pylori seropositivityPancreatic cancer riskPylori seropositivityPancreatic cancerOdds ratioCancer riskAustralian population-based case-control studyConfidence intervalsH. pyloriPopulation-based case-control studyHelicobacter pyloriOverall associationStrain-specific associationsLaird random-effects modelAdjusted odds ratioCase-control studyCytotoxin-associated geneSignificant overall associationRandom-effects modelEnzyme-linked immunosorbentPancreatic cancer studiesCagA seropositivityMethodsBlood samplesEpidemiological studiesSeropositivity
2014
Helicobacter pylori Seropositivities and Risk of Pancreatic Carcinoma
Risch HA, Lu L, Kidd MS, Wang J, Zhang W, Ni Q, Gao YT, Yu H. Helicobacter pylori Seropositivities and Risk of Pancreatic Carcinoma. Cancer Epidemiology Biomarkers & Prevention 2014, 23: 172-178. PMID: 24234587, PMCID: PMC3947155, DOI: 10.1158/1055-9965.epi-13-0447.Peer-Reviewed Original ResearchConceptsCagA-positive strainsPancreatic cancerPancreatic carcinomaCagA seropositivityPylori seropositivityPylori colonizationGastric acidityH. pyloriLarge population-based case-control studyPopulation-based case-control studyPancreas cancer riskParticular cancer siteVirulence protein CagAHelicobacter pylori seropositivityH. pylori seropositivityBody mass indexH. pylori colonizationCase-control studyHelicobacter pylori colonizationH. pylori CagAStrain typesPathophysiologic actionsVenipuncture specimensAntibody seropositivityCase patients
2011
Pancreatic cancer: Helicobacter pylori colonization, N‐Nitrosamine exposures, and ABO blood group
Risch HA. Pancreatic cancer: Helicobacter pylori colonization, N‐Nitrosamine exposures, and ABO blood group. Molecular Carcinogenesis 2011, 51: 109-118. PMID: 22162235, DOI: 10.1002/mc.20826.Peer-Reviewed Original ResearchConceptsN-nitrosamine exposurePancreatic cancerPylori colonizationH. pyloriPancreatic secretory functionH. pylori colonizationHost inflammatory responseHelicobacter pylori colonizationHost-organism interactionsABO blood groupH. pylori bindsPancreatic carcinogenicityRecent genome-wide association studiesCigarette smokingGastric ulcerRisk factorsDietary intakeInflammatory responsePancreatic adenocarcinomaGastric cancerPhysiologic actionsAnimal modelsGastrointestinal epitheliumGastric colonizationHelicobacter pylori