Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria
Baker KC, Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Sun F, Wild R, Masson P, Smith JF, Santoro N, Zhang H, Network R. Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria. F&S Reports 2022, 3: 110-115. PMID: 35789726, PMCID: PMC9250115, DOI: 10.1016/j.xfre.2022.03.003.Peer-Reviewed Original ResearchFertility centerCore laboratoryStrict morphologySecondary cohort analysisPlacebo-controlled trialSame semen sampleMultisite clinical trialLower reference limitSemen samplesInfertility trialsClinical trialsFertility laboratoriesCohort analysisCutoff valueEffect of antioxidantsReference limitsInterobserver agreementCentral laboratoryModerate agreementSemen valuesLack of correlationTrialsGrading criteriaMale fertilityCenter Laboratory