2023
Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original ResearchPaired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2018
A community-based evaluation of proximity to unconventional oil and gas wells, drinking water contaminants, and health symptoms in Ohio
Elliott EG, Ma X, Leaderer BP, McKay LA, Pedersen CJ, Wang C, Gerber CJ, Wright TJ, Sumner AJ, Brennan M, Silva GS, Warren JL, Plata DL, Deziel NC. A community-based evaluation of proximity to unconventional oil and gas wells, drinking water contaminants, and health symptoms in Ohio. Environmental Research 2018, 167: 550-557. PMID: 30145431, DOI: 10.1016/j.envres.2018.08.022.Peer-Reviewed Original Research
2017
Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy
Warren JL, Son JY, Pereira G, Leaderer BP, Bell ML. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy. American Journal Of Epidemiology 2017, 187: 992-1000. PMID: 29053768, PMCID: PMC5928458, DOI: 10.1093/aje/kwx335.Peer-Reviewed Original ResearchConceptsLow birth weightTerm low birth weightMaternal residential mobilityBirth weightCritical windowBirth cohortWeekly exposurePregnancy week 16Adverse birth outcomesWindow of susceptibilityAmbient air pollutionPregnancy windowsBirth outcomesWeek 16Mother's residencePM10 exposurePregnancyResidential addressesExposure misclassificationDisease developmentCohortAir pollutionExposureAerodynamic diameterPossible mechanismTraffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population
Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2017, 13: 342-347. PMID: 28730729, PMCID: PMC5775922, DOI: 10.1111/ijpo.12228.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseTraffic-related air pollutionNon-alcoholic steatohepatitisHepatic fat fractionCK-18Pre-existing non-alcoholic fatty liver diseaseCytokeratin 18Fatty liver diseaseObese pediatric populationPediatric obesity clinicNitrogen dioxide exposureMagnetic resonance imagingObesity clinicStudy entryFatty liverLiver diseaseObese childrenPediatric populationLiver enzymesLiver susceptibilityHepatocellular apoptosisAnimal modelsResidential buffersResonance imagingAir pollution associationsNIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management. Journal Of Allergy And Clinical Immunology 2017, 140: 933-949. PMID: 28502823, PMCID: PMC5632590, DOI: 10.1016/j.jaci.2017.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAnimalsAsthmaBiomedical ResearchChildConsensus Development Conferences, NIH as TopicDrug IndustryEnvironmental HealthFund RaisingHumansNational Heart, Lung, and Blood Institute (U.S.)National Institute of Allergy and Infectious Diseases (U.S.)National Institute of Environmental Health Sciences (U.S.)Organizations, NonprofitUnited StatesConceptsEnvironmental exposuresCommon chronic childhood diseaseEnvironmental interventionsMerck Childhood Asthma NetworkControl of asthmaExacerbation of asthmaManagement of asthmaChronic childhood diseaseHome environmental interventionsExposure reduction techniquesNational InstituteAirway allergyAsthma preventionAsthma managementAsthma NetworkBlood InstituteChildhood asthmaNational HeartChildhood diseasesAsthmaEnvironmental Health SciencesInfectious diseasesStudy designBiologic propertiesIndoor exposure
2016
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence
Elliott EG, Trinh P, Ma X, Leaderer BP, Ward MH, Deziel NC. Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. The Science Of The Total Environment 2016, 576: 138-147. PMID: 27783932, PMCID: PMC6457992, DOI: 10.1016/j.scitotenv.2016.10.072.Peer-Reviewed Original ResearchConceptsWater contaminantsPotential water contaminantsMajority of compoundsWater pollutantsPolycyclic aromatic hydrocarbonsHydraulic fracturing fluidsPollutantsAromatic hydrocarbonsAir pollutantsU.S. Environmental Protection AgencyCompoundsEnvironmental Protection AgencyPotential air pollutantsPossible human carcinogenContaminantsChemicalsCarcinogenicity of compoundsLeukemia/lymphomaProtection AgencyChildhood leukemiaWaterButadieneBenzeneFracturing fluidOilIndoor microbial communities: Influence on asthma severity in atopic and nonatopic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children. Journal Of Allergy And Clinical Immunology 2016, 138: 76-83.e1. PMID: 26851966, PMCID: PMC5357886, DOI: 10.1016/j.jaci.2015.11.027.Peer-Reviewed Original ResearchConceptsAsthma severityAtopic statusAtopic childrenNonatopic childrenLogistic regressionMicrobial exposureChildhood asthma severityCohort of childrenAsthmatic childrenAllergenic fungal speciesTotal fungal concentrationsSeverityHouse dustCryptococcus speciesExposure metricsChildrenT-testCohortQuantitative PCRFungal concentrationsAssociationExposureNext-generation DNA sequencingStatusRegressionSpatiotemporal calibration and resolution refinement of output from deterministic models
Gilani O, McKay LA, Gregoire TG, Guan Y, Leaderer BP, Holford TR. Spatiotemporal calibration and resolution refinement of output from deterministic models. Statistics In Medicine 2016, 35: 2422-2440. PMID: 26790617, DOI: 10.1002/sim.6867.Peer-Reviewed Original ResearchConceptsGrid-cell formatCurrent calibration techniquesSpatiotemporal calibrationModeling strategyCommunity Multiscale Air Quality (CMAQ) modelAir quality modelsMultiscale Air Quality modelCalibration techniqueObserved measurementsPixel sizeSpatial resolutionGrid dataMonitoring stationsQuality modelDeterministic modelRegular gridAmbient nitrogen dioxide concentrationsDaily estimatesMeasurementsProcess of interestGridNitrogen dioxide concentrationsProcessPixelsDioxide concentrationHousehold concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels
Li T, Cao S, Fan D, Zhang Y, Wang B, Zhao X, Leaderer BP, Shen G, Zhang Y, Duan X. Household concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels. The Science Of The Total Environment 2016, 548: 6-12. PMID: 26799802, PMCID: PMC4760902, DOI: 10.1016/j.scitotenv.2016.01.038.Peer-Reviewed Original ResearchConceptsInhalation exposure levelsExposure levelsEnvironmental risk factorsTotal PM2.5 exposuresDifferent cooking fuelsDifferent age groupsRisk factorsPM2.5 exposureAge groupsPremature deathHousehold concentrationsPersonal exposureIndoor combustion sourcesHigher indoor concentrationsCooking fuelExposureOutdoor PM2.5 concentrationsNon-heating seasonLevelsIndoor concentrationsDiseaseA systematic evaluation of chemicals in hydraulic-fracturing fluids and wastewater for reproductive and developmental toxicity
Elliott EG, Ettinger AS, Leaderer BP, Bracken MB, Deziel NC. A systematic evaluation of chemicals in hydraulic-fracturing fluids and wastewater for reproductive and developmental toxicity. Journal Of Exposure Science & Environmental Epidemiology 2016, 27: 90-99. PMID: 26732376, DOI: 10.1038/jes.2015.81.Peer-Reviewed Original ResearchConceptsWater quality standardsFederal water quality standardsQuality standardsHuman health impactsNatural gas developmentEnvironmental concentrationsHundreds of substancesDevelopmental toxicityReprotox databasesHuman exposureToxicity informationGas developmentExposure assessmentIncorporation of dataHealth StudyHealth impactsSystematic screening approachHydraulic-fracturing fluidsChemical Abstract Service Registry NumbersCandidate analytesChemicalsDrinking waterLikely etiologic agentWastewaterUnconventional oil
2015
Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children. Indoor Air 2015, 26: 179-192. PMID: 25833176, PMCID: PMC4591094, DOI: 10.1111/ina.12205.Peer-Reviewed Original ResearchConceptsHousing characteristicsCommunity structureFungal community structureAC usePresence of petsBacterial community structureIndoor microbial communitiesBeneficial bacterial taxaNext-generation DNA sequencingAir conditioning useMicrobial assemblyFungal communitiesMicrobial ecologyCommunity compositionMicrobial communitiesBacterial communitiesBacterial taxaSpecies segregationLevel of urbanizationMicrobial richnessOccupancy characteristicsSuburban homesWater leaksSouthern New EnglandOccupant characteristicsDistributions of heavy metals in maternal and cord blood and the association with infant birth weight in China.
Hu X, Zheng T, Cheng Y, Holford T, Lin S, Leaderer B, Qiu J, Bassig BA, Shi K, Zhang Y, Niu J, Zhu Y, Li Y, Guo H, Chen Q, Zhang J, Xu S, Jin Y. Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China. The Journal Of Reproductive Medicine 2015, 60: 21-9. PMID: 25745747, PMCID: PMC4961246.Peer-Reviewed Original ResearchConceptsInfant birth weightCord blood samplesBirth weightCord bloodBlood samplesChinese pregnant womenMother-infant pairsBirth outcomesSerum levelsPregnant womenPrenatal exposureSerum concentrationsChinese infantsMultiple linear regression analysisLarger sample sizeLinear regression analysisSignificant associationChinese womenPilot studyBloodRegression analysisNewbornsAssociationWomenHigh concentrations
2014
Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China
Zhao N, Qiu J, Zhang Y, He X, Zhou M, Li M, Xu X, Cui H, Lv L, Lin X, Zhang C, Zhang H, Xu R, Zhu D, Lin R, Yao T, Su J, Dang Y, Han X, Zhang H, Bai H, Chen Y, Tang Z, Wang W, Wang Y, Liu X, Ma B, Liu S, Qiu W, Huang H, Liang J, Chen Q, Jiang M, Ma S, Jin L, Holford T, Leaderer B, Bell ML, Liu Q, Zhang Y. Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China. Environment International 2014, 76: 71-77. PMID: 25553395, PMCID: PMC4526148, DOI: 10.1016/j.envint.2014.12.009.Peer-Reviewed Original ResearchConceptsPreterm birthEntire pregnancyClinical subtypesUnconditional logistic regression modelingVery preterm birthSingleton live birthsBirth cohort studyLimited epidemiologic studiesMonths of pregnancyExposure time windowsLogistic regression modelingHigh-level exposureHealth policy makersHigh exposure levelsLast 6weeksCohort studyVery pretermRisk factorsLive birthsPM10 exposureEpidemiologic studiesAir pollution levelsPregnancyLevel exposureExposure levelsAsthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbation
2013
Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons ≥ 65 Years of Age
Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons ≥ 65 Years of Age. Environmental Health Perspectives 2013, 122: 138-144. PMID: 24213019, PMCID: PMC3915260, DOI: 10.1289/ehp.1306656.Peer-Reviewed Original ResearchHousehold Levels of Nitrogen Dioxide and Pediatric Asthma Severity
Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology 2013, 24: 320-330. PMID: 23337243, PMCID: PMC3686297, DOI: 10.1097/ede.0b013e318280e2ac.Peer-Reviewed Original ResearchConceptsAsthma severityNight symptomsAsthma morbiditySeverity scoreNO2 exposureHigher asthma severity scoresFrequency of wheezeIndoor NO2 exposurePediatric asthma severityRescue medication useIndoor allergen exposureAsthma severity scoreAdverse respiratory effectsDose-dependent increaseYears of ageInner-city childrenLogistic regression modelsRescue medicationActive asthmaAllergen exposureAsthmatic childrenMedication useRespiratory effectsChildren 5Health outcomes
2012
Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity
Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity. Environmental Research 2012, 118: 86-93. PMID: 22863552, PMCID: PMC3604733, DOI: 10.1016/j.envres.2012.07.005.Peer-Reviewed Original ResearchConceptsRisk of wheezeSpecific allergen sensitizationRescue medication useChildhood asthma morbidityAsthma severity scoreMedication useAllergen sensitizationPersistent coughAsthma morbiditySeverity scoreHigher asthma severity scoresCommon household allergensCommon indoor allergensFel d 1Der p 1Asthma exacerbationsAllergen exposureLevel of exposureAsthmatic childrenDer pAllergy testingIndoor allergensSchool-aged childrenPet allergensDust allergensAn environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood