2023
Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original Research
2016
Spatiotemporal calibration and resolution refinement of output from deterministic models
Gilani O, McKay LA, Gregoire TG, Guan Y, Leaderer BP, Holford TR. Spatiotemporal calibration and resolution refinement of output from deterministic models. Statistics In Medicine 2016, 35: 2422-2440. PMID: 26790617, DOI: 10.1002/sim.6867.Peer-Reviewed Original ResearchConceptsGrid-cell formatCurrent calibration techniquesSpatiotemporal calibrationModeling strategyCommunity Multiscale Air Quality (CMAQ) modelAir quality modelsMultiscale Air Quality modelCalibration techniqueObserved measurementsPixel sizeSpatial resolutionGrid dataMonitoring stationsQuality modelDeterministic modelRegular gridAmbient nitrogen dioxide concentrationsDaily estimatesMeasurementsProcess of interestGridNitrogen dioxide concentrationsProcessPixelsDioxide concentration
2015
Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children. Indoor Air 2015, 26: 179-192. PMID: 25833176, PMCID: PMC4591094, DOI: 10.1111/ina.12205.Peer-Reviewed Original ResearchMeSH KeywordsAir MicrobiologyAir Pollution, IndoorAsthmaBacteriaChildEnvironmental ExposureFungiHousingHumansConceptsHousing characteristicsCommunity structureFungal community structureAC usePresence of petsBacterial community structureIndoor microbial communitiesBeneficial bacterial taxaNext-generation DNA sequencingAir conditioning useMicrobial assemblyFungal communitiesMicrobial ecologyCommunity compositionMicrobial communitiesBacterial communitiesBacterial taxaSpecies segregationLevel of urbanizationMicrobial richnessOccupancy characteristicsSuburban homesWater leaksSouthern New EnglandOccupant characteristics
2014
Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China
Zhao N, Qiu J, Zhang Y, He X, Zhou M, Li M, Xu X, Cui H, Lv L, Lin X, Zhang C, Zhang H, Xu R, Zhu D, Lin R, Yao T, Su J, Dang Y, Han X, Zhang H, Bai H, Chen Y, Tang Z, Wang W, Wang Y, Liu X, Ma B, Liu S, Qiu W, Huang H, Liang J, Chen Q, Jiang M, Ma S, Jin L, Holford T, Leaderer B, Bell ML, Liu Q, Zhang Y. Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China. Environment International 2014, 76: 71-77. PMID: 25553395, PMCID: PMC4526148, DOI: 10.1016/j.envint.2014.12.009.Peer-Reviewed Original ResearchConceptsPreterm birthEntire pregnancyClinical subtypesUnconditional logistic regression modelingVery preterm birthSingleton live birthsBirth cohort studyLimited epidemiologic studiesMonths of pregnancyExposure time windowsLogistic regression modelingHigh-level exposureHealth policy makersHigh exposure levelsLast 6weeksCohort studyVery pretermRisk factorsLive birthsPM10 exposureEpidemiologic studiesAir pollution levelsPregnancyLevel exposureExposure levels
2013
Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity
Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology 2013, 24: 320-330. PMID: 23337243, PMCID: PMC3686297, DOI: 10.1097/ede.0b013e318280e2ac.Peer-Reviewed Original ResearchConceptsAsthma severityNight symptomsAsthma morbiditySeverity scoreNO2 exposureHigher asthma severity scoresFrequency of wheezeIndoor NO2 exposurePediatric asthma severityRescue medication useIndoor allergen exposureAsthma severity scoreAdverse respiratory effectsDose-dependent increaseYears of ageInner-city childrenLogistic regression modelsRescue medicationActive asthmaAllergen exposureAsthmatic childrenMedication useRespiratory effectsChildren 5Health outcomes
2012
Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity
Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity. Environmental Research 2012, 118: 86-93. PMID: 22863552, PMCID: PMC3604733, DOI: 10.1016/j.envres.2012.07.005.Peer-Reviewed Original ResearchMeSH KeywordsAllergensAsthmaChildChild, PreschoolDustEnvironmental ExposureFemaleFungiHumansMaleResidence CharacteristicsConceptsRisk of wheezeSpecific allergen sensitizationRescue medication useChildhood asthma morbidityAsthma severity scoreMedication useAllergen sensitizationPersistent coughAsthma morbiditySeverity scoreHigher asthma severity scoresCommon household allergensCommon indoor allergensFel d 1Der p 1Asthma exacerbationsAllergen exposureLevel of exposureAsthmatic childrenDer pAllergy testingIndoor allergensSchool-aged childrenPet allergensDust allergensAn environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBloodEffects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children
DellaValle CT, Triche EW, Leaderer BP, Bell ML. Effects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children. Epidemiology 2012, 23: 55-63. PMID: 22082997, PMCID: PMC3246281, DOI: 10.1097/ede.0b013e31823b66b8.Peer-Reviewed Original ResearchConceptsShortness of breathRescue medication useAsthma maintenance medicationsMaintenance medicationPersistent coughSensitized childrenChest tightnessNight symptomsAsthmatic childrenMedication usePollen exposureSeverity of asthmaDaily respiratory symptomsWeed pollenLogistic regression analysisLow exposureSeparate logistic regression analysesAsthmatic symptomsRespiratory symptomsDaily symptomsAntibiotic useSymptom outcomesDaily ambientMedicationsAmbient pollen concentrations
2011
Urban land-use and respiratory symptoms in infants
Ebisu K, Holford TR, Belanger KD, Leaderer BP, Bell ML. Urban land-use and respiratory symptoms in infants. Environmental Research 2011, 111: 677-684. PMID: 21530957, PMCID: PMC3114197, DOI: 10.1016/j.envres.2011.04.004.Peer-Reviewed Original Research
2009
Integrated exposure modeling: A model using GIS and GLM
Holford TR, Ebisu K, McKay LA, Gent JF, Triche EW, Bracken MB, Leaderer BP. Integrated exposure modeling: A model using GIS and GLM. Statistics In Medicine 2009, 29: 116-129. PMID: 19823976, PMCID: PMC3182125, DOI: 10.1002/sim.3732.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsConnecticutEnvironmental ExposureGeographic Information SystemsHumansInfantModels, StatisticalNitrogen DioxideVehicle EmissionsConceptsGeneralized linear modelLinear modelLayout of roadsDispersion functionStatistical modelStandard regression techniquesTraffic-related health effectsSecond examplePollutant dispersionSpline modelSpatial modelRegression techniquesDaily trafficConnecticut homesIntegralsModelTraffic densityDispersionGLMTrafficVariablesFunctionMeteorologyTraffic-related pollutionHousehold airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAsthmaChildEnvironmental ExposureFemaleHousingHumansLogistic ModelsMaleMitosporic FungiOdds RatioPeak Expiratory Flow RatePenicilliumConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalence
2001
Carbon Monoxide As a Tracer for Assessing Exposures to Particulate Matter in Wood and Gas Cookstove Households of Highland Guatemala
Naeher L, Smith K, Leaderer B, Neufeld L, Mage D. Carbon Monoxide As a Tracer for Assessing Exposures to Particulate Matter in Wood and Gas Cookstove Households of Highland Guatemala. Environmental Science And Technology 2001, 35: 575-581. PMID: 11351731, DOI: 10.1021/es991225g.Peer-Reviewed Original ResearchAir Pollution, IndoorCarbon MonoxideCookingEnvironmental ExposureGuatemalaHumansParticle SizePropaneWood
2000
Indoor and outdoor PM2.5 and CO in high- and low-density Guatemalan villages
NAEHER L, SMITH K, LEADERER B, MAGE D, GRAJEDA R. Indoor and outdoor PM2.5 and CO in high- and low-density Guatemalan villages. Journal Of Exposure Science & Environmental Epidemiology 2000, 10: 544-551. PMID: 11140438, DOI: 10.1038/sj.jea.7500113.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorCarbon MonoxideCookingDeveloping CountriesEnvironmental ExposureEnvironmental MonitoringGuatemalaHousingHumansParticle SizePublic HealthParticulate Matter and Carbon Monoxide in Highland Guatemala: Indoor and Outdoor Levels from Traditional and Improved Wood Stoves and Gas Stoves
Naeher L, Leaderer B, Smith K. Particulate Matter and Carbon Monoxide in Highland Guatemala: Indoor and Outdoor Levels from Traditional and Improved Wood Stoves and Gas Stoves. Indoor Air 2000, 10: 200-205. PMID: 10979201, DOI: 10.1034/j.1600-0668.2000.010003200.x.Peer-Reviewed Original Research
1999
Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters.
Leaderer B, Naeher L, Jankun T, Balenger K, Holford T, Toth C, Sullivan J, Wolfson J, Koutrakis P. Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters. Environmental Health Perspectives 1999, 107: 223-231. PMID: 10064553, PMCID: PMC1566377, DOI: 10.1289/ehp.99107223.Peer-Reviewed Original Research
1998
Correlates of Residential Wiring Code Used in Studies of Health Effects of Residential Electromagnetic Fields
Bracken M, Belanger K, Hellenbrand K, Addesso K, Patel S, Triche E, Leaderer B. Correlates of Residential Wiring Code Used in Studies of Health Effects of Residential Electromagnetic Fields. American Journal Of Epidemiology 1998, 148: 467-474. PMID: 9737559, DOI: 10.1093/oxfordjournals.aje.a009672.Peer-Reviewed Original ResearchMeSH KeywordsAdultConfounding Factors, EpidemiologicConnecticutElectromagnetic FieldsEnvironmental ExposureFemaleHousingHumans
1996
Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
Beckett W, Belanger K, Gent J, Holford T, Leaderer B. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 894-899. PMID: 8887582, DOI: 10.1164/ajrccm.154.4.8887582.Peer-Reviewed Original ResearchConceptsRisk factorsPuerto Rican HispanicsSocioeconomic statusHispanic ethnicityHispanic mothersEnvironmental tobacco smoke exposureIndependent risk factorPhysician-diagnosed asthmaPrevalence of asthmaTobacco smoke exposureStrong risk factorAfrican American ethnicityEnvironmental risk factorsYr of ageLow socioeconomic statusStudy of asthmaNon-Hispanic whitesMo of ageActive smokingAsthmatic childrenSmoke exposureChildhood asthmaCigarette smokersMaternal ageMaternal history
1995
EXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS
Bracken M, Belanger K, Hellenbrand K, Dlugosz L, Holford T, McSharry J, Addesso K, Leaderer B. EXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS. Epidemiology 1995, 6: 263-270. PMID: 7619934, DOI: 10.1097/00001648-199505000-00013.Peer-Reviewed Original ResearchConceptsFetal growth retardationGrowth retardationBed useIntrauterine growth retardationVideo display terminal useDose-response relationPersonal monitorsEMF exposureTime-weighted analysisMonitoring of exposureThird trimesterProspective studyFetal growthWire codesHome measurementsReproductive outcomesHuman studiesPregnancyStudy designVideo display terminalsExposure measuresHours of useMeaningful increaseRiskExposure
1993
Assessing exposures to inhaled complex mixtures.
Leaderer B, Lioy P, Spengler J. Assessing exposures to inhaled complex mixtures. Environmental Health Perspectives 1993, 101: 167-177. PMID: 8206025, PMCID: PMC1519694, DOI: 10.1289/ehp.93101s4167.Peer-Reviewed Original Research
1990
Assessing Exposures to Environmental Tobacco Smoke
Leaderer B. Assessing Exposures to Environmental Tobacco Smoke. Risk Analysis 1990, 10: 19-26. PMID: 2184472, DOI: 10.1111/j.1539-6924.1990.tb01016.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBiomarkersEnvironmental ExposureHumansModels, TheoreticalNicotinePlants, ToxicRisk FactorsSmokeSmokingSurveys and QuestionnairesTobacco