2023
Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAsthmaChildEnvironmental MonitoringFeasibility StudiesHumansNitrogen DioxideProspective StudiesConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir Pollution, IndoorAsthmaChildHousehold ProductsHumansMassachusettsNitrogen DioxideParticulate MatterConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2017
NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management. Journal Of Allergy And Clinical Immunology 2017, 140: 933-949. PMID: 28502823, PMCID: PMC5632590, DOI: 10.1016/j.jaci.2017.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAnimalsAsthmaBiomedical ResearchChildConsensus Development Conferences, NIH as TopicDrug IndustryEnvironmental HealthFund RaisingHumansNational Heart, Lung, and Blood Institute (U.S.)National Institute of Allergy and Infectious Diseases (U.S.)National Institute of Environmental Health Sciences (U.S.)Organizations, NonprofitUnited StatesConceptsEnvironmental exposuresCommon chronic childhood diseaseEnvironmental interventionsMerck Childhood Asthma NetworkControl of asthmaExacerbation of asthmaManagement of asthmaChronic childhood diseaseHome environmental interventionsExposure reduction techniquesNational InstituteAirway allergyAsthma preventionAsthma managementAsthma NetworkBlood InstituteChildhood asthmaNational HeartChildhood diseasesAsthmaEnvironmental Health SciencesInfectious diseasesStudy designBiologic propertiesIndoor exposure
2016
Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children. Journal Of Allergy And Clinical Immunology 2016, 138: 76-83.e1. PMID: 26851966, PMCID: PMC5357886, DOI: 10.1016/j.jaci.2015.11.027.Peer-Reviewed Original ResearchConceptsAsthma severityAtopic statusAtopic childrenNonatopic childrenLogistic regressionMicrobial exposureChildhood asthma severityCohort of childrenAsthmatic childrenAllergenic fungal speciesTotal fungal concentrationsSeverityHouse dustCryptococcus speciesExposure metricsChildrenT-testCohortQuantitative PCRFungal concentrationsAssociationExposureNext-generation DNA sequencingStatusRegressionHousehold concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels
Li T, Cao S, Fan D, Zhang Y, Wang B, Zhao X, Leaderer BP, Shen G, Zhang Y, Duan X. Household concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels. The Science Of The Total Environment 2016, 548: 6-12. PMID: 26799802, PMCID: PMC4760902, DOI: 10.1016/j.scitotenv.2016.01.038.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir Pollution, IndoorChinaCookingEnvironmental MonitoringFamily CharacteristicsHumansInhalation ExposureParticulate MatterConceptsInhalation exposure levelsExposure levelsEnvironmental risk factorsTotal PM2.5 exposuresDifferent cooking fuelsDifferent age groupsRisk factorsPM2.5 exposureAge groupsPremature deathHousehold concentrationsPersonal exposureIndoor combustion sourcesHigher indoor concentrationsCooking fuelExposureOutdoor PM2.5 concentrationsNon-heating seasonLevelsIndoor concentrationsDisease
2015
Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children. Indoor Air 2015, 26: 179-192. PMID: 25833176, PMCID: PMC4591094, DOI: 10.1111/ina.12205.Peer-Reviewed Original ResearchMeSH KeywordsAir MicrobiologyAir Pollution, IndoorAsthmaBacteriaChildEnvironmental ExposureFungiHousingHumansConceptsHousing characteristicsCommunity structureFungal community structureAC usePresence of petsBacterial community structureIndoor microbial communitiesBeneficial bacterial taxaNext-generation DNA sequencingAir conditioning useMicrobial assemblyFungal communitiesMicrobial ecologyCommunity compositionMicrobial communitiesBacterial communitiesBacterial taxaSpecies segregationLevel of urbanizationMicrobial richnessOccupancy characteristicsSuburban homesWater leaksSouthern New EnglandOccupant characteristics
2014
Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAir Pollution, IndoorAsthmaFemaleHumansHypoxiaNitrogen DioxidePregnancyPregnancy ComplicationsRespiratory SoundsRisk FactorsYoung AdultConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbation
2013
Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity
Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology 2013, 24: 320-330. PMID: 23337243, PMCID: PMC3686297, DOI: 10.1097/ede.0b013e318280e2ac.Peer-Reviewed Original ResearchConceptsAsthma severityNight symptomsAsthma morbiditySeverity scoreNO2 exposureHigher asthma severity scoresFrequency of wheezeIndoor NO2 exposurePediatric asthma severityRescue medication useIndoor allergen exposureAsthma severity scoreAdverse respiratory effectsDose-dependent increaseYears of ageInner-city childrenLogistic regression modelsRescue medicationActive asthmaAllergen exposureAsthmatic childrenMedication useRespiratory effectsChildren 5Health outcomes
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorAsthmaChildEnvironmental ExposureFemaleHousingHumansLogistic ModelsMaleMitosporic FungiOdds RatioPeak Expiratory Flow RatePenicilliumConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalence
2006
Comparison of parental reports of smoking and residential air nicotine concentrations in children
Gehring U, Leaderer B, Heinrich J, Oldenwening M, Giovannangelo M, Nordling E, Merkel G, Hoek G, Bellander T, Brunekreef B. Comparison of parental reports of smoking and residential air nicotine concentrations in children. Occupational And Environmental Medicine 2006, 63: 766. PMID: 16912089, PMCID: PMC2077986, DOI: 10.1136/oem.2006.027151.Peer-Reviewed Original ResearchConceptsAir nicotine concentrationsEnvironmental tobacco smokeUrinary cotinine measurementsNicotine concentrationsETS exposureResidential exposureCotinine measurementsPredictive valueAir nicotine levelsUrinary cotinine levelsUrinary cotinine concentrationsChildren's residential exposureQuestionnaire reportsDose-response fashionResidential ETS exposureNegative predictive valuePositive predictive valueAir nicotineCotinine levelsCotinine concentrationsSymptomatic childrenOccasional smokersSymptom statusTobacco smokeNicotine levels
2005
Indoor nitrous acid and respiratory symptoms and lung function in adults
Jarvis D, Leaderer B, Chinn S, Burney P. Indoor nitrous acid and respiratory symptoms and lung function in adults. Thorax 2005, 60: 474. PMID: 15923247, PMCID: PMC1747426, DOI: 10.1136/thx.2004.032177.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollution, IndoorFemaleForced Expiratory VolumeHumansMaleNitrous AcidRespiration DisordersVital CapacityConceptsLung functionRespiratory symptomsHealth effectsIndoor NO2Lower lung functionMore respiratory symptomsNon-significant increaseFEV1/Expiratory volumeVital capacityRelevant confoundersSecond percentageEpidemiological studiesSignificant associationSymptomsHome levelAssociationAdultsOutdoor levelsHigh levelsLevelsFailureConfoundersMonths
2004
The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States
Van Strien R, Gehring U, Belanger K, Triche E, Gent J, Bracken M, Leaderer B. The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States. Allergy 2004, 59: 645-652. PMID: 15147450, DOI: 10.1111/j.1398-9995.2004.00470.x.Peer-Reviewed Original Research
2001
The relation between fungal propagules in indoor air and home characteristics
Ren P, Jankun T, Belanger K, Bracken M, Leaderer B. The relation between fungal propagules in indoor air and home characteristics. Allergy 2001, 56: 419-424. PMID: 11350305, DOI: 10.1034/j.1398-9995.2001.056005419.x.Peer-Reviewed Original ResearchMeSH KeywordsAir MicrobiologyAir Pollution, IndoorAnimalsAnimals, DomesticAsthmaCatsEnvironmental MonitoringEpidemiological MonitoringFamily CharacteristicsFungiHeatingHousingHumansHumidityIncomeInfantNew EnglandPredictive Value of TestsProspective StudiesSeasonsSurveys and QuestionnairesTime FactorsVentilationConceptsCFU/m3 airInfants' bedroomsMain living areaProspective cohort studyDevelopment of asthmaHome characteristicsAnnual household incomeAllergen exposureCohort studyEpidemiologic studiesM3 airPresence of petsExposure levelsExposure assessmentSignificant differencesBurkard portable air samplerLiving areasQuestionnaireIndoor airFungal exposure assessmentHouse characteristicsHousehold incomeHomeDG-18AsthmaCarbon Monoxide As a Tracer for Assessing Exposures to Particulate Matter in Wood and Gas Cookstove Households of Highland Guatemala
Naeher L, Smith K, Leaderer B, Neufeld L, Mage D. Carbon Monoxide As a Tracer for Assessing Exposures to Particulate Matter in Wood and Gas Cookstove Households of Highland Guatemala. Environmental Science And Technology 2001, 35: 575-581. PMID: 11351731, DOI: 10.1021/es991225g.Peer-Reviewed Original ResearchAir Pollution, IndoorCarbon MonoxideCookingEnvironmental ExposureGuatemalaHumansParticle SizePropaneWood
2000
Indoor and outdoor PM2.5 and CO in high- and low-density Guatemalan villages
NAEHER L, SMITH K, LEADERER B, MAGE D, GRAJEDA R. Indoor and outdoor PM2.5 and CO in high- and low-density Guatemalan villages. Journal Of Exposure Science & Environmental Epidemiology 2000, 10: 544-551. PMID: 11140438, DOI: 10.1038/sj.jea.7500113.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollution, IndoorCarbon MonoxideCookingDeveloping CountriesEnvironmental ExposureEnvironmental MonitoringGuatemalaHousingHumansParticle SizePublic HealthParticulate Matter and Carbon Monoxide in Highland Guatemala: Indoor and Outdoor Levels from Traditional and Improved Wood Stoves and Gas Stoves
Naeher L, Leaderer B, Smith K. Particulate Matter and Carbon Monoxide in Highland Guatemala: Indoor and Outdoor Levels from Traditional and Improved Wood Stoves and Gas Stoves. Indoor Air 2000, 10: 200-205. PMID: 10979201, DOI: 10.1034/j.1600-0668.2000.010003200.x.Peer-Reviewed Original Research
1999
Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters.
Leaderer B, Naeher L, Jankun T, Balenger K, Holford T, Toth C, Sullivan J, Wolfson J, Koutrakis P. Indoor, outdoor, and regional summer and winter concentrations of PM10, PM2.5, SO4(2)-, H+, NH4+, NO3-, NH3, and nitrous acid in homes with and without kerosene space heaters. Environmental Health Perspectives 1999, 107: 223-231. PMID: 10064553, PMCID: PMC1566377, DOI: 10.1289/ehp.99107223.Peer-Reviewed Original Research
1995
The accuracy of environmental tobacco smoke exposure measures among asthmatic children
Emerson J, Hovell M, Meltzer S, Zakarian J, Hofstetter C, Wahlgren D, Leaderer B, Meltzer E. The accuracy of environmental tobacco smoke exposure measures among asthmatic children. Journal Of Clinical Epidemiology 1995, 48: 1251-1259. PMID: 7561987, DOI: 10.1016/0895-4356(95)00021-u.Peer-Reviewed Original ResearchConceptsResidential ETS exposureETS exposureAsthmatic childrenParent-report measuresEnvironmental tobacco smoke exposureResidential exposureUrine cotinine assayTobacco smoke exposureChildren's residential exposureTest-retest reliability assessmentSmoke exposureCotinine assaysHome exposureEpidemiological investigationsClinical programsExposure measuresConstruct validity testParent reportExposureDiscriminant validityChildrenReportNicotineMeasuresEffect of nitrous acid on lung function in asthmatics: a chamber study.
Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.Peer-Reviewed Original ResearchConceptsSignificant airflow obstructionChamber exposure studiesFiltered room airModerate cycle exerciseNitrous acid exposureIndoor nitrogen dioxideMucous membrane symptomsDuration of exposureAirflow obstructionLung functionIrritant symptomsVital capacityCycle exerciseLung mechanicsRespiratory effectsAcid exposureRespiratory parametersAdult subjectsRoom airHealth effectsSymptomsSignificant decreaseAsthmaticsExposure studiesCommon indoor air pollutants
1991
Indoor exposures to fine aerosols and acid gases.
Koutrakis P, Brauer M, Briggs S, Leaderer B. Indoor exposures to fine aerosols and acid gases. Environmental Health Perspectives 1991, 95: 23-28. PMID: 1821374, PMCID: PMC1568412, DOI: 10.1289/ehp.919523.Peer-Reviewed Original ResearchConceptsAir Quality StudyParticle elemental compositionAcid gasesIndoor air quality studiesDiverse industrial activitiesIdentification of sourcesNumerous indoor sourcesFine aerosolsAir pollution sourcesPollution sourcesAerosolsIndoor aerosolsImportance of reactionsIndustrial activitiesAir qualityIndoor environmentIndoor air qualityCoal combustionElemental compositionFine particlesAir exchange rateIndoor/outdoor ratiosParticle sizeOutdoor sourcesQuality studies