2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2009
Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
2005
Indoor nitrous acid and respiratory symptoms and lung function in adults
Jarvis D, Leaderer B, Chinn S, Burney P. Indoor nitrous acid and respiratory symptoms and lung function in adults. Thorax 2005, 60: 474. PMID: 15923247, PMCID: PMC1747426, DOI: 10.1136/thx.2004.032177.Peer-Reviewed Original ResearchConceptsLung functionRespiratory symptomsHealth effectsIndoor NO2Lower lung functionMore respiratory symptomsNon-significant increaseFEV1/Expiratory volumeVital capacityRelevant confoundersSecond percentageEpidemiological studiesSignificant associationSymptomsHome levelAssociationAdultsOutdoor levelsHigh levelsLevelsFailureConfoundersMonths
2003
Asthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies
Bracken M, Triche E, Belanger K, Saftlas A, Beckett W, Leaderer B. Asthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies. Obstetrics And Gynecology 2003, 102: 739. DOI: 10.1097/00006250-200310000-00016.Peer-Reviewed Original ResearchAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaPregnant patientsAsthma therapySymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionΒ2 agonistsAsthmaSymptomsMedications
2001
A childhood asthma severity scale: symptoms, medications, and health care visits
Ortega A, Belanger K, Bracken M, Leaderer B. A childhood asthma severity scale: symptoms, medications, and health care visits. Annals Of Allergy Asthma & Immunology 2001, 86: 405-413. PMID: 11345283, DOI: 10.1016/s1081-1206(10)62486-6.Peer-Reviewed Original ResearchConceptsHealth care visitsChildhood asthma severityCare visitsAsthma severityLarge-scale epidemiologic studiesAsthma severity scaleMedication useSeverity ScaleEpidemiologic studiesHome interviewsProspective cohort studyHealth care utilizationCohort studyAsthmatic childrenCare utilizationDaily symptomsInsurance statusConnecticut hospitalsGeneral populationClinimetric propertiesClinimetric validityMaternal educationClinical diagnosisParticipant characteristicsSymptoms
2000
Model for the Analysis of Binary Time Series of Respiratory Symptoms
Zhang H, Triche E, Leaderer B. Model for the Analysis of Binary Time Series of Respiratory Symptoms. American Journal Of Epidemiology 2000, 151: 1206-1215. PMID: 10905533, DOI: 10.1093/oxfordjournals.aje.a010171.Peer-Reviewed Original ResearchConceptsDuration of symptomsRespiratory symptomsNew episodesStuffy nosePrior historyHistory of allergyDaily respiratory symptomsInfant Health StudyMeteorologic changesHealth StudySymptomsEpidemiologic researchDay careMarital statusIncidenceEnvironmental epidemiologic researchEpisodesMothersDurationSulfate levelsHusband's levelDemographic variablesNoseHigh levelsAllergy
1996
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response
Cain W, Leaderer B, Ginsberg G, Andrews L, Cometto-muñiz J, Gent J, Buck M, Berglund L, Mohsenin V, Monahan E, Kjaergaard S. Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response. Inhalation Toxicology 1996, 8: 21-48. DOI: 10.3109/08958379609005425.Peer-Reviewed Original ResearchDouble-blind studyEnd of exposureNasal inflammationBlood levelsAcute exposureComputerized performance testsHealthy adultsPharmacokinetic responseEye irritationSymptomsPharmacokinetic studyMethyl tertiary butyl etherDifferential effectsObjective effectsObjective correlatesExposureSubjectsPMNTertiary butyl etherOne-halfSubjects' ratingsInflammationLevelsBloodBaseline
1995
Effect of nitrous acid on lung function in asthmatics: a chamber study.
Beckett W, Russi M, Haber A, Rivkin R, Sullivan J, Tameroglu Z, Mohsenin V, Leaderer B. Effect of nitrous acid on lung function in asthmatics: a chamber study. Environmental Health Perspectives 1995, 103: 372-375. PMID: 7607138, PMCID: PMC1519093, DOI: 10.1289/ehp.95103372.Peer-Reviewed Original ResearchConceptsSignificant airflow obstructionChamber exposure studiesFiltered room airModerate cycle exerciseNitrous acid exposureIndoor nitrogen dioxideMucous membrane symptomsDuration of exposureAirflow obstructionLung functionIrritant symptomsVital capacityCycle exerciseLung mechanicsRespiratory effectsAcid exposureRespiratory parametersAdult subjectsRoom airHealth effectsSymptomsSignificant decreaseAsthmaticsExposure studiesCommon indoor air pollutants
1993
Personal Risk Factors Associated with Mucosal Symptom Prevalence in Office Workers
Hall H, Leaderer B, Cain W, Fidler A. Personal Risk Factors Associated with Mucosal Symptom Prevalence in Office Workers. Indoor Air 1993, 3: 206-209. DOI: 10.1111/j.1600-0668.1993.t01-1-00006.x.Peer-Reviewed Original ResearchPersonal risk factorsSymptom prevalenceRisk factorsMultivariate logistic regression analysisSelf-reported allergiesLogistic regression analysisAdverse health effectsChest illnessSymptom occurrenceHealth factorsHealth symptomsSymptom reportingHealth effectsIrritantsOffice workersRegression analysisPrevalenceWorkstation characteristicsAir breaksAllergyIllnessSymptomsFactorsComplaintsWomenMucosal irritation and thermal comfort among occupants of an office building
Hall H, Leaderer B, Cain W, Fidler A. Mucosal irritation and thermal comfort among occupants of an office building. Environment International 1993, 19: 253-259. DOI: 10.1016/0160-4120(93)90086-w.Peer-Reviewed Original Research
1989
Lower respiratory symptoms in children exposed to nitrogen dioxide from unvented combustion sources
Berwick M, Leaderer B, Stolwijk J, Zagraniski R. Lower respiratory symptoms in children exposed to nitrogen dioxide from unvented combustion sources. Environment International 1989, 15: 369-373. DOI: 10.1016/0160-4120(89)90050-0.Peer-Reviewed Original ResearchProspective epidemiologic studiesRespiratory symptomsRespiratory illnessIndoor air contaminant levelsRespiratory healthEpidemiologic studiesSubjects' homesExposure classificationStudy designSocioeconomic statusTwo-week periodYoung childrenNitrogen dioxide levelsChildrenAgeUnvented combustion sourcesNitrogen dioxideSymptomsIllnessWeeks
1987
A study of respiratory effects from exposure to 2.0 ppm formaldehyde in occupationally exposed workers
Schachter E, Witek T, Brody D, Tosun T, Beck G, Leaderer B. A study of respiratory effects from exposure to 2.0 ppm formaldehyde in occupationally exposed workers. Environmental Research 1987, 44: 188-205. PMID: 3691441, DOI: 10.1016/s0013-9351(87)80227-x.Peer-Reviewed Original ResearchConceptsPeak expiratory flow rateLung functionLaboratory workersExposure daysHospital laboratory workersLower airway symptomsLung function changesHealthy laboratory workersExpiratory flow rateAirway symptomsObstructive changesAsthmatic individualsIrritative symptomsSymptom diaryExercise regimenAsthmatic symptomatologyMild exerciseRespiratory effectsPEFR recordingsFrequent complaintEye irritationMore occasionsSymptomsPpm formaldehydeUnusual odorAn evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity.
Witek T, Schachter E, Tosun T, Beck G, Leaderer B. An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity. Archives Of Environmental & Occupational Health 1987, 42: 230-7. PMID: 3310924.Peer-Reviewed Original ResearchConceptsMethacholine inhalation challenge testFlow-volume parametersInhalation challenge testSignificant airway obstructionAirway reactivityAirway obstructionAirway responsesAsthmatic volunteersLung functionSore throatAirway resistanceMethacholine concentrationModerate exerciseRespiratory effectsFormaldehyde exposurePpm exposureChallenge testSeparate daysEye irritationMedian decrementAsthmaticsSymptomsExposurePpm formaldehydeDegrees C
1986
Controlled human studies on the pulmonary effects of indoor air pollution: Experiences with sulful dioxide and formaldehyde
Witek T, Schachter E, Tosun T, Leaderer B, Beck G. Controlled human studies on the pulmonary effects of indoor air pollution: Experiences with sulful dioxide and formaldehyde. Environment International 1986, 12: 129-135. DOI: 10.1016/0160-4120(86)90023-1.Peer-Reviewed Original Research
1985
Respiratory symptoms associated with sulfur dioxide exposure
Witek T, Schachter E, Beck G, Cain W, Colice G, Leaderer B. Respiratory symptoms associated with sulfur dioxide exposure. International Archives Of Occupational And Environmental Health 1985, 55: 179-183. PMID: 3988360, DOI: 10.1007/bf00378381.Peer-Reviewed Original ResearchConceptsAsthmatic subjectsHealthy subjectsDose-dependent bronchoconstrictionLower airway symptomsUpper airway complaintsSeverity of complaintsLower respiratory complaintsSulfur dioxide exposureAirway complaintsAirway symptomsChest tightnessRespiratory symptomsRespiratory complaintsClinical significanceSymptomsComplaintsAsthmaticsSubjective responsesSensitive individualsSubjectsExposureLevels of SO2DyspneaBronchoconstrictionSeverity
1979
Ambient sulfates, photochemical oxidants, and acute adverse health effects: An epidemiological study
Zagraniski R, Leaderer B, Stolwijk J. Ambient sulfates, photochemical oxidants, and acute adverse health effects: An epidemiological study. Environmental Research 1979, 19: 306-320. PMID: 315309, DOI: 10.1016/0013-9351(79)90058-6.Peer-Reviewed Original ResearchConceptsAcute adverse health effectsAdverse health effectsHealth effectsTelephone company employeesAsthma clinicChronic bronchitisGroups of subjectsHeavy smokersAcute symptomsSymptom ratesHay feverThroat irritationEpidemiological studiesMore symptomsSuch illnessesEye irritationSusceptible peopleConnecticut areaSmokersIllnessSymptomsIrritationOxidant levelsGroupNew Haven