2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2017
Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy
Warren JL, Son JY, Pereira G, Leaderer BP, Bell ML. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy. American Journal Of Epidemiology 2017, 187: 992-1000. PMID: 29053768, PMCID: PMC5928458, DOI: 10.1093/aje/kwx335.Peer-Reviewed Original ResearchConceptsLow birth weightTerm low birth weightMaternal residential mobilityBirth weightCritical windowBirth cohortWeekly exposurePregnancy week 16Adverse birth outcomesWindow of susceptibilityAmbient air pollutionPregnancy windowsBirth outcomesWeek 16Mother's residencePM10 exposurePregnancyResidential addressesExposure misclassificationDisease developmentCohortAir pollutionExposureAerodynamic diameterPossible mechanism
2016
Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children. Journal Of Allergy And Clinical Immunology 2016, 138: 76-83.e1. PMID: 26851966, PMCID: PMC5357886, DOI: 10.1016/j.jaci.2015.11.027.Peer-Reviewed Original ResearchConceptsAsthma severityAtopic statusAtopic childrenNonatopic childrenLogistic regressionMicrobial exposureChildhood asthma severityCohort of childrenAsthmatic childrenAllergenic fungal speciesTotal fungal concentrationsSeverityHouse dustCryptococcus speciesExposure metricsChildrenT-testCohortQuantitative PCRFungal concentrationsAssociationExposureNext-generation DNA sequencingStatusRegressionHousehold concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels
Li T, Cao S, Fan D, Zhang Y, Wang B, Zhao X, Leaderer BP, Shen G, Zhang Y, Duan X. Household concentrations and personal exposure of PM2.5 among urban residents using different cooking fuels. The Science Of The Total Environment 2016, 548: 6-12. PMID: 26799802, PMCID: PMC4760902, DOI: 10.1016/j.scitotenv.2016.01.038.Peer-Reviewed Original ResearchConceptsInhalation exposure levelsExposure levelsEnvironmental risk factorsTotal PM2.5 exposuresDifferent cooking fuelsDifferent age groupsRisk factorsPM2.5 exposureAge groupsPremature deathHousehold concentrationsPersonal exposureIndoor combustion sourcesHigher indoor concentrationsCooking fuelExposureOutdoor PM2.5 concentrationsNon-heating seasonLevelsIndoor concentrationsDisease
2014
Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbation
2012
Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation
Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012, 117: 83-89. PMID: 22705336, PMCID: PMC3418490, DOI: 10.1016/j.envres.2012.05.004.Peer-Reviewed Original ResearchConceptsLow birth weightBirth weightAdverse pregnancy outcomesPregnancy outcomesTerm infantsAirborne fine particulate matterStudy populationIQR increaseMothers' exposureAfrican American mothersFirst birthInfantsEffect estimatesConfidence intervalsWhite mothersPregnancyHealth impactsRiskExposureFine particulate matterMothersMost studiesGestationWeight
2010
Prenatal Exposure to Fine Particulate Matter and Birth Weight
Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP. Prenatal Exposure to Fine Particulate Matter and Birth Weight. Epidemiology 2010, 21: 884-891. PMID: 20811286, PMCID: PMC3055585, DOI: 10.1097/ede.0b013e3181f2f405.Peer-Reviewed Original Research
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalenceSymptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
1999
Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3
NAEHER L, HOLFORD T, BECKETT W, BELANGER K, TRICHE E, BRACKEN M, LEADERER B. Healthy Women's PEF Variations with Ambient Summer Concentrations of PM10, PM2.5, SO4 2 −, H+, and O3. American Journal Of Respiratory And Critical Care Medicine 1999, 160: 117-125. PMID: 10390388, DOI: 10.1164/ajrccm.160.1.9808153.Peer-Reviewed Original ResearchConceptsPeak expiratory flowPEF variationEvening peak expiratory flowMorning peak expiratory flowOutdoor monitoring sitePeak flow meterAmbient air pollutionMicrograms/m3Expiratory flowPhysiologic effectsPEF measurementsOnly exposureConcurrent measuresExposureMeteorologic variablesFine particulate sulfateDaily
1998
Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds
Belanger K, Leaderer B, Hellenbrand K, Holford T, McSharry J, Power M, Bracken M. Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds. Epidemiology 1998, 9: 36-42. PMID: 9430266, DOI: 10.1097/00001648-199801000-00009.Peer-Reviewed Original ResearchConceptsElectric blanket useSpontaneous abortionPregnancy lossBlanket useEarly pregnancy lossHeated water bedsTime of conceptionMonth of conceptionWire code categoriesWeeks' gestationProspective studyEarly pregnancyUnadjusted analysesBed useGreater riskPregnancyAbortionDose responseWomenRiskElectric bedElectric blanketExposureSlight increaseGestation
1996
Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response
Cain W, Leaderer B, Ginsberg G, Andrews L, Cometto-muñiz J, Gent J, Buck M, Berglund L, Mohsenin V, Monahan E, Kjaergaard S. Acute Exposure to Low-Level Methyl Tertiary-Butyl Ether (MTBE): Human Reactions and Pharmacokinetic Response. Inhalation Toxicology 1996, 8: 21-48. DOI: 10.3109/08958379609005425.Peer-Reviewed Original ResearchDouble-blind studyEnd of exposureNasal inflammationBlood levelsAcute exposureComputerized performance testsHealthy adultsPharmacokinetic responseEye irritationSymptomsPharmacokinetic studyMethyl tertiary butyl etherDifferential effectsObjective effectsObjective correlatesExposureSubjectsPMNTertiary butyl etherOne-halfSubjects' ratingsInflammationLevelsBloodBaseline
1995
Measurement of Exposure to Environmental Tobacco Smoke in Pregnant Women
O'Connor T, Holford T, Leaderer B, Hammond S, Bracken M. Measurement of Exposure to Environmental Tobacco Smoke in Pregnant Women. American Journal Of Epidemiology 1995, 142: 1315-1321. PMID: 7503052, DOI: 10.1093/oxfordjournals.aje.a117599.Peer-Reviewed Original ResearchConceptsUrine cotinineEnvironmental tobacco smokePregnant womenTobacco smokeWork exposureAir nicotine concentrationsSelf-reported exposurePersonal air monitorsExposure assessment methodsAir nicotineMeasurement of exposureHome exposureCotinineNicotine concentrationsExposure classificationWomenCohen's kappaExposureSpearman rank-order correlation coefficientAir monitorsRank-order correlation coefficientKappaSocial exposureSmokeHigh levelsThe accuracy of environmental tobacco smoke exposure measures among asthmatic children
Emerson J, Hovell M, Meltzer S, Zakarian J, Hofstetter C, Wahlgren D, Leaderer B, Meltzer E. The accuracy of environmental tobacco smoke exposure measures among asthmatic children. Journal Of Clinical Epidemiology 1995, 48: 1251-1259. PMID: 7561987, DOI: 10.1016/0895-4356(95)00021-u.Peer-Reviewed Original ResearchConceptsResidential ETS exposureETS exposureAsthmatic childrenParent-report measuresEnvironmental tobacco smoke exposureResidential exposureUrine cotinine assayTobacco smoke exposureChildren's residential exposureTest-retest reliability assessmentSmoke exposureCotinine assaysHome exposureEpidemiological investigationsClinical programsExposure measuresConstruct validity testParent reportExposureDiscriminant validityChildrenReportNicotineMeasuresEXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS
Bracken M, Belanger K, Hellenbrand K, Dlugosz L, Holford T, McSharry J, Addesso K, Leaderer B. EXPOSURE TO ELECTROMAGNETIC FIELDS DURING PREGNANCY WITH EMPHASIS ON ELECTRICALLY HEATED BEDS. Epidemiology 1995, 6: 263-270. PMID: 7619934, DOI: 10.1097/00001648-199505000-00013.Peer-Reviewed Original ResearchConceptsFetal growth retardationGrowth retardationBed useIntrauterine growth retardationVideo display terminal useDose-response relationPersonal monitorsEMF exposureTime-weighted analysisMonitoring of exposureThird trimesterProspective studyFetal growthWire codesHome measurementsReproductive outcomesHuman studiesPregnancyStudy designVideo display terminalsExposure measuresHours of useMeaningful increaseRiskExposure
1994
Reduction of Environmental Tobacco Smoke Exposure Among Asthmatic Children: A Controlled Trial
Hovell M, Meltzer S, Zakarian J, Wahlgren D, Emerson J, Hofstetter C, Leaderer B, Meltzer E, Zeiger R, O’Connor R, Mulvihill M, Atkins C. Reduction of Environmental Tobacco Smoke Exposure Among Asthmatic Children: A Controlled Trial. CHEST Journal 1994, 106: 440-446. PMID: 7774317, DOI: 10.1378/chest.106.2.440.Peer-Reviewed Original ResearchConceptsTreatment control groupEnvironmental tobacco smokeETS exposureControl groupAsthma symptomsChildren's ETS exposureChildren's asthma symptomsExperimental groupMonitoring control groupBehavioral medicine programRepeated-measures analysisAllergy clinicClinical trialsOutcome measuresTobacco smokeExposure reportsChildren's exposureMonitoring groupCounseling sessionsPercent decreaseMedicine programsCounseling groupDaily numberExposureCigarettes
1993
Assessing exposures to inhaled complex mixtures.
Leaderer B, Lioy P, Spengler J. Assessing exposures to inhaled complex mixtures. Environmental Health Perspectives 1993, 101: 167-177. PMID: 8206025, PMCID: PMC1519694, DOI: 10.1289/ehp.93101s4167.Peer-Reviewed Original Research
1990
Assessing Exposures to Environmental Tobacco Smoke
Leaderer B. Assessing Exposures to Environmental Tobacco Smoke. Risk Analysis 1990, 10: 19-26. PMID: 2184472, DOI: 10.1111/j.1539-6924.1990.tb01016.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1987
An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity.
Witek T, Schachter E, Tosun T, Beck G, Leaderer B. An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity. Archives Of Environmental & Occupational Health 1987, 42: 230-7. PMID: 3310924.Peer-Reviewed Original ResearchConceptsMethacholine inhalation challenge testFlow-volume parametersInhalation challenge testSignificant airway obstructionAirway reactivityAirway obstructionAirway responsesAsthmatic volunteersLung functionSore throatAirway resistanceMethacholine concentrationModerate exerciseRespiratory effectsFormaldehyde exposurePpm exposureChallenge testSeparate daysEye irritationMedian decrementAsthmaticsSymptomsExposurePpm formaldehydeDegrees C
1986
ASSESSMENT OF EXPOSURE TO INDOOR AIR CONTAMINANTS FROM COMBUSTION SOURCES: METHODOLOGY AND APPLICATION
LEADERER B, ZAGRANISKI R, BERWICK M, STOLWIJK J. ASSESSMENT OF EXPOSURE TO INDOOR AIR CONTAMINANTS FROM COMBUSTION SOURCES: METHODOLOGY AND APPLICATION. American Journal Of Epidemiology 1986, 124: 275-289. PMID: 3088984, DOI: 10.1093/oxfordjournals.aje.a114386.Peer-Reviewed Original ResearchConceptsAcute respiratory illnessIndoor air pollutant exposuresPersonal NO2 exposuresAir pollutant exposureIndoor NO2 levelsUnvented kerosene space heatersTobacco smokersIndoor air contaminant levelsRespiratory illnessAssessment of exposureIndoor NO2Health effectsEnvironmental exposuresLevels of NO2Unvented combustionNO2 exposureExposure assessmentNational health standardsGas cooking stovesKerosene space heatersPollutant exposureNO2 levelsKerosene heatersExcellent predictorExposure