2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2016
Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children. Journal Of Allergy And Clinical Immunology 2016, 138: 76-83.e1. PMID: 26851966, PMCID: PMC5357886, DOI: 10.1016/j.jaci.2015.11.027.Peer-Reviewed Original ResearchConceptsAsthma severityAtopic statusAtopic childrenNonatopic childrenLogistic regressionMicrobial exposureChildhood asthma severityCohort of childrenAsthmatic childrenAllergenic fungal speciesTotal fungal concentrationsSeverityHouse dustCryptococcus speciesExposure metricsChildrenT-testCohortQuantitative PCRFungal concentrationsAssociationExposureNext-generation DNA sequencingStatusRegression
2012
An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood
2009
Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children
Bundy KW, Gent JF, Beckett W, Bracken MB, Belanger K, Triche E, Leaderer BP. Household airborne Penicillium associated with peak expiratory flow variability in asthmatic children. Annals Of Allergy Asthma & Immunology 2009, 103: 26-30. PMID: 19663123, PMCID: PMC2746059, DOI: 10.1016/s1081-1206(10)60139-1.Peer-Reviewed Original ResearchConceptsPeak expiratory flow variabilityExpiratory flow variabilityAsthmatic childrenAirway hyperreactivityPeak expiratory flowYears of ageLogistic regression modelsAsthma prevalencePhysician diagnosisExpiratory flowChildren 6HyperreactivityChildrenAirborne mold concentrationsRegression modelsAgeCommon moldsIndoor fungiExposureMold concentrationsHomeAsthmaAirborne fungiTotal moldPrevalenceSymptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution
Gent JF, Koutrakis P, Belanger K, Triche E, Holford TR, Bracken MB, Leaderer BP. Symptoms and Medication Use in Children with Asthma and Traffic-Related Sources of Fine Particle Pollution. Environmental Health Perspectives 2009, 117: 1168-1174. PMID: 19654929, PMCID: PMC2717146, DOI: 10.1289/ehp.0800335.Peer-Reviewed Original ResearchConceptsMedication useInhaler useLikelihood of wheezeExacerbation of asthmaMeasures logistic regression modelsRisk of symptomsRespiratory health effectsYears of ageHealth outcomes riskLikelihood of symptomsLogistic regression modelsAsthma 4Outcome riskAsthmaHealth outcomesDaily exposureSymptomsHealth effectsStudy diariesParticle exposureHealth impactsChildrenPublic healthExposureRegression models
2001
Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Children
von Maffei J, Beckett W, Belanger K, Triche E, Zhang H, Machung J, Leaderer B. Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Children. Journal Of Asthma 2001, 38: 555-564. PMID: 11714078, DOI: 10.1081/jas-100107120.Peer-Reviewed Original ResearchConceptsRisk factorsUrban residenceAfrican American childrenMaternal cigarette smokingPhysician-diagnosed asthmaMultiple risk factorsYears of ageMaternal asthmaAsthmatic childrenAsthma prevalenceCigarette smokingAsthmaAmerican childrenAfrican American mothersIdentifiable factorsChildrenAmerican mothersResidenceFactorsSmokingAllergyNewbornsPrevalence
1995
The accuracy of environmental tobacco smoke exposure measures among asthmatic children
Emerson J, Hovell M, Meltzer S, Zakarian J, Hofstetter C, Wahlgren D, Leaderer B, Meltzer E. The accuracy of environmental tobacco smoke exposure measures among asthmatic children. Journal Of Clinical Epidemiology 1995, 48: 1251-1259. PMID: 7561987, DOI: 10.1016/0895-4356(95)00021-u.Peer-Reviewed Original ResearchConceptsResidential ETS exposureETS exposureAsthmatic childrenParent-report measuresEnvironmental tobacco smoke exposureResidential exposureUrine cotinine assayTobacco smoke exposureChildren's residential exposureTest-retest reliability assessmentSmoke exposureCotinine assaysHome exposureEpidemiological investigationsClinical programsExposure measuresConstruct validity testParent reportExposureDiscriminant validityChildrenReportNicotineMeasures
1989
Lower respiratory symptoms in children exposed to nitrogen dioxide from unvented combustion sources
Berwick M, Leaderer B, Stolwijk J, Zagraniski R. Lower respiratory symptoms in children exposed to nitrogen dioxide from unvented combustion sources. Environment International 1989, 15: 369-373. DOI: 10.1016/0160-4120(89)90050-0.Peer-Reviewed Original ResearchProspective epidemiologic studiesRespiratory symptomsRespiratory illnessIndoor air contaminant levelsRespiratory healthEpidemiologic studiesSubjects' homesExposure classificationStudy designSocioeconomic statusTwo-week periodYoung childrenNitrogen dioxide levelsChildrenAgeUnvented combustion sourcesNitrogen dioxideSymptomsIllnessWeeks