2023
Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2014
Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide
Gent JF, Kezik JM, Hill ME, McKay LA, Holford TR, Leaderer BP, Bracken MB. Asthma medication use during pregnancy, wheeze and estimated exposure to ambient nitrogen dioxide. European Respiratory Journal 2014, 45: 538-540. PMID: 25537555, PMCID: PMC4331059, DOI: 10.1183/09031936.00161514.Peer-Reviewed Original ResearchConceptsAsthma medication useMedication usePregnant womenRisk of wheezePoor pulmonary functionAdverse health outcomesPregnant asthmaticsAsthma exacerbationsAsthma medicationsPerinatal complicationsPulmonary functionFetal growthHealth outcomesPregnancyNO2 exposureWheezeAsthmaMedicationsWomenAmbient nitrogen dioxideMothersMinimal effectExposureAsthmaticsExacerbation
2012
Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity
Gent JF, Kezik JM, Hill ME, Tsai E, Li DW, Leaderer BP. Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity. Environmental Research 2012, 118: 86-93. PMID: 22863552, PMCID: PMC3604733, DOI: 10.1016/j.envres.2012.07.005.Peer-Reviewed Original ResearchConceptsRisk of wheezeSpecific allergen sensitizationRescue medication useChildhood asthma morbidityAsthma severity scoreMedication useAllergen sensitizationPersistent coughAsthma morbiditySeverity scoreHigher asthma severity scoresCommon household allergensCommon indoor allergensFel d 1Der p 1Asthma exacerbationsAllergen exposureLevel of exposureAsthmatic childrenDer pAllergy testingIndoor allergensSchool-aged childrenPet allergensDust allergensAn environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood