2024
Updated CP*Trends: An Online Tool to Compare Cohort and Period Trends across Cancer Sites
Holford T, Chen H, Kane M, Krapcho M, Annett D, Esclamado L, Melkonyan A, Feuer E. Updated CP*Trends: An Online Tool to Compare Cohort and Period Trends across Cancer Sites. American Journal Of Epidemiology 2024, kwae398. PMID: 39475089, DOI: 10.1093/aje/kwae398.Peer-Reviewed Original ResearchCancer sitesAfrican AmericansCervical cancer incidence trendsCancer incidence trendsMortality trendsCancer incidenceIncidence trendsEffect of cohortConfidence intervalsPeriod effectsInteractive websiteCohortAmericanSample sizeScoresWhiteEffects of periodMortalityCancerC-P scoreBootstrap confidence intervalsIncidenceSEERWebsitesTrends
2019
CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites
Holford TR, Chen HS, Annett D, Krapcho M, Dorogaeva A, Feuer EJ. CP*Trends: An Online Tool for Comparing Cohort and Period Trends Across Cancer Sites. American Journal Of Epidemiology 2019, 188: 1361-1370. PMID: 30989187, PMCID: PMC6601534, DOI: 10.1093/aje/kwz089.Peer-Reviewed Original ResearchConceptsColorectal cancer incidenceCancer incidenceCancer sitesContribution of periodMale prostate cancerEnd Results (SEER) dataStudy of etiologyFemale lungCancer mortalityBronchial cancerProstate cancerCohortDisease controlRelevant exposuresIncidenceAge shiftLungCancerMortalityP scoreAgeResult dataPeriod trendsPeriodPercentage of deviance
2015
Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate
Oh C, Holford TR. Age‐Period‐Cohort approaches to back‐calculation of cancer incidence rate. Statistics In Medicine 2015, 34: 1953-1964. PMID: 25715831, PMCID: PMC4980760, DOI: 10.1002/sim.6464.Peer-Reviewed Original ResearchConceptsCancer incidence ratesEstimates of incidenceHealth care planningCancer deathLung cancerCancer prevalenceCancer incidenceIncidence rateHealthy subjectsCare planningSurvival informationMortality statisticsCancerIncidence casesIncidenceAge periodDeathSubjectsCompartment modelCohortMortalityPrevalence
2012
Chapter 12: Yale Lung Cancer Model
Holford TR, Ebisu K, McKay L, Oh C, Zheng T. Chapter 12: Yale Lung Cancer Model. Risk Analysis 2012, 32: s151-s165. PMID: 22882886, PMCID: PMC3662537, DOI: 10.1111/j.1539-6924.2011.01754.x.Peer-Reviewed Original ResearchConceptsLung cancer deathsCarcinogenesis modelCancer deathLung cancer incidenceLung cancer modelTwo-stage clonal expansion modelCigarette smokingCancer incidenceCancer modelTobacco controlClonal expansion modelPopulation ratesCohort modelSmokingDeathHarmful effectsPopulation dataTemporal trendsMortalityObserved numberIncidenceControl
1997
The increase of Hodgkin's disease incidence among young adults
Chen Y, Zheng T, Chou M, Boyle P, Holford T. The increase of Hodgkin's disease incidence among young adults. Cancer 1997, 79: 2209-2218. PMID: 9179069, DOI: 10.1002/(sici)1097-0142(19970601)79:11<2209::aid-cncr20>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsHodgkin's disease incidenceHodgkin's diseaseRisk factorsVirus infectionYoung adultsEpstein-Barr virus infectionHuman immunodeficiency virus (HIV) infectionConnecticut Tumor RegistryImmunodeficiency virus infectionAnalytical epidemiologic studiesMajor risk factorIncidence rate changesAdults ages 20Young adults ages 20Tumor RegistryHistologic typeDisease incidenceCohort analysisEpidemiologic studiesAge 20Cohort patternsCohort phenomenonIncidenceDiseaseYoung females
1996
Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Mayne S, Liu W, Flannery J, Boyle P. Time trend and age‐period‐cohort effect on incidence of bladder cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 68: 172-176. PMID: 8900423, DOI: 10.1002/(sici)1097-0215(19961009)68:2<172::aid-ijc5>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsUrinary bladder cancerMajor risk factorBladder cancerRisk factorsIncidence rateBirth-cohort patternSmoking-related cancersAnalytical epidemiologic studiesTime trendsTobacco smokingCigarette smokingLung cancerOccupational exposureEpidemiologic studiesCancerMarked increaseSmokingCohort effectsMalesRecent studiesCurrent studyFemalesIncidenceStudyConnecticutTime trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992
Zheng T, Holford T, Chen Y, Z. J, Flannery J, Liu W, Russi M, Boyle P. Time trend and age‐period‐cohort effect on incidence of thyroid cancer in Connecticut, 1935–1992. International Journal Of Cancer 1996, 67: 504-509. PMID: 8759608, DOI: 10.1002/(sici)1097-0215(19960807)67:4<504::aid-ijc7>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsThyroid cancerChildhood conditionsOverall age-adjusted incidence rateStrong birth cohort effectAge-adjusted incidence ratesRadiation treatmentBirth cohort effectsBirth cohort analysisTime trendsCohort effectsObserved time trendsIncidence ratePapillary carcinomaCohort analysisCancerCohortIncidenceNeckMalesFemalesUnited StatesRecent studiesTreatmentCurrent studyCarcinomaA MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT
HOLFORD T, ZHANG Z, ZHENG T, MCKAY L. A MODEL FOR THE EFFECT OF CIGARETTE SMOKING ON LUNG CANCER INCIDENCE IN CONNECTICUT. Statistics In Medicine 1996, 15: 565-580. PMID: 8731001, DOI: 10.1002/(sici)1097-0258(19960330)15:6<565::aid-sim185>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsLung cancer incidenceCancer incidenceIncidence rateLung cancer incidence ratesLung cancer incidence trendsEffect of smokingCancer incidence ratesCancer incidence trendsCohort studyCurrent smokersLevel of exposureMale smokersSmoking historySmoking subgroupsSmoking informationCigarette smokingMean durationSmoking prevalenceIncidence trendsSmokersSmokingPrevalenceCohort effectsAge distributionIncidence
1995
Time trend in pancreatic cancer incidence in connecticut, 1935–1990
Zheng T, Holford T, Ward B, McKay L, Flannery J, Boyle P. Time trend in pancreatic cancer incidence in connecticut, 1935–1990. International Journal Of Cancer 1995, 61: 622-627. PMID: 7768634, DOI: 10.1002/ijc.2910610507.Peer-Reviewed Original ResearchConceptsOverall age-adjusted incidence rateAge-adjusted incidence ratesIncidence rateRecent birth cohortsPancreatic cancerBirth cohortIncident pancreatic cancer casesPancreatic cancer incidence ratesAge groupsAge-specific incidence ratesPancreatic cancer incidenceConnecticut Tumor RegistryBirth cohort trendsPancreatic cancer casesCancer incidence ratesTumor RegistryCancer incidenceCancer casesCohort modelingCohort trendsTime trendsCohortCancerIncidenceSex
1994
Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site
Chen Y, Zheng T, Holford T, Berwick M, Dubrow R. Malignant melanoma incidence in Connecticut (United States): time trends and age-period-cohort modeling by anatomic site. Cancer Causes & Control 1994, 5: 341-350. PMID: 8080946, DOI: 10.1007/bf01804985.Peer-Reviewed Original ResearchConceptsCutaneous malignant melanomaAnatomic sitesUpper limbPopulation-based Connecticut Tumor RegistryCohort patternsConnecticut Tumor RegistryMale-female ratioMalignant melanoma incidenceTime trendsCMM incidenceNeck melanomaTumor RegistryIncident casesMalignant melanomaMelanoma incidenceEtiologic distinctionsCarcinogenic exposuresLower limbsLargest absolute increaseMelanomaCohort modelingAbsolute increaseIncidenceLimbLargest relative increaseTime trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989
Katz D, Zheng T, Holford T, Flannery J. Time trends in the incidence of renal carcinoma: Analysis of connecticut tumor registry data, 1935‐1989. International Journal Of Cancer 1994, 58: 57-63. PMID: 8014016, DOI: 10.1002/ijc.2910580111.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaConnecticut Tumor RegistryCell carcinomaIncidence rateRenal cancerPopulation-based cancer registriesIncidence of adenocarcinomaTime trendsCohort effectsRegression modellingEffect of ageTumor RegistryCancer RegistryIncident casesUrinary tractRenal carcinomaBirth cohortCarcinomaAdenocarcinomaRate of riseIncidenceNegative cohort effectRegistryCancerMales
1993
Age‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in connecticut
Dubrow R, Bernstein J, Holford T. Age‐period‐cohort modelling of large‐bowel‐cancer incidence by anatomic sub‐site and sex in connecticut. International Journal Of Cancer 1993, 53: 907-913. PMID: 8473049, DOI: 10.1002/ijc.2910530607.Peer-Reviewed Original ResearchConceptsLeft colonCohort patternsTransverse colonLarge bowelCancer incidenceEtiologic distinctionsConnecticut Tumor RegistryTumor RegistrySigmoid colonCancer casesCohort modellingBirth cohortConnecticut residentsColonRectumCohort modelSexBowelIncidenceDiagnosisMalesFemalesCommon patternRegistryCohort
1992
Analysing the temporal effects of age, period and cohort
Holford T. Analysing the temporal effects of age, period and cohort. Statistical Methods In Medical Research 1992, 1: 317-337. PMID: 1341663, DOI: 10.1177/096228029200100306.Peer-Reviewed Original ResearchCross-cultural association between dietary animal protein and hip fracture: A hypothesis
Abelow B, Holford T, Insogna K. Cross-cultural association between dietary animal protein and hip fracture: A hypothesis. Calcified Tissue International 1992, 50: 14-18. PMID: 1739864, DOI: 10.1007/bf00297291.Peer-Reviewed Original ResearchConceptsHip fracture incidenceFracture incidenceDietary animal proteinHigh animal protein dietTotal caloric intakeAnimal protein dietHip fractureDietary calciumFracture ratesCaloric intakeBone bufferingFracture associationMetabolic acid productionBone dissolutionProtein dietFurther studiesPositive associationProtein consumptionAnimal proteinIncidenceAssociationAnimal protein consumptionRecent studies
1991
Trends in female breast cancer in Connecticut and the United States
Holford T, Roush G, McKay L. Trends in female breast cancer in Connecticut and the United States. Journal Of Clinical Epidemiology 1991, 44: 29-39. PMID: 1986055, DOI: 10.1016/0895-4356(91)90198-i.Peer-Reviewed Original ResearchConceptsBreast cancer mortalityBirth-cohort patternFemale breast cancerBreast cancerCancer mortalityCohort patternsPostmenopausal breast cancerInvasive breast cancerBlind biopsyBirth cohortMortalityCancerCohort modelingEarly detectionPrior reportsImproved treatmentTime trendsCohortU.S. mortalityModest declineLittle evidenceImportant differencesBiopsyIncidenceUnderdetection
1987
Time and age trends for sinonasal cancer in connecticut incidence and US mortality rates
Roush G, Schymura M, Stevenson J, Holford T. Time and age trends for sinonasal cancer in connecticut incidence and US mortality rates. Cancer 1987, 60: 422-428. PMID: 3594381, DOI: 10.1002/1097-0142(19870801)60:3<422::aid-cncr2820600324>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsUS mortality ratesSinonasal cancerMortality rateBirth cohortMortality dataPostmenopausal age groupFemale breast cancerPopulation-based ratesUS mortality dataAge distributionClemmesen's hookCigarette smokingNongynecologic malignanciesEtiologic roleSex hormonesBreast cancerAge 50Male subjectsAge groupsFemale subjectsIncidence dataCohortAge rangeCancerIncidence
1985
Risk for cutaneous melanoma in recent Connecticut birth cohorts.
Roush G, Schymura M, Holford T. Risk for cutaneous melanoma in recent Connecticut birth cohorts. American Journal Of Public Health 1985, 75: 679-82. PMID: 4003640, PMCID: PMC1646211, DOI: 10.2105/ajph.75.6.679.Peer-Reviewed Original Research
1978
Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia
Livolsi V, Stadel B, Kelsey J, Holford T, White C. Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia. New England Journal Of Medicine 1978, 299: 381-385. PMID: 566853, DOI: 10.1056/nejm197808242990803.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseOral contraceptivesLong-term usersBreast cancerEpithelial atypiaFibrocystic diseaseBreast diseaseOral contraceptive usersLong-term usePremenopausal womenHistopathological evaluationHistologic standpointCystic diseasePremalignant formsEpidemiological studiesDiseaseContraceptivesAtypiaCancerWomenSignificant differencesNontakersIncidence