2021
Incidence and prevalence of tuberculosis in incarcerated populations: a systematic review and meta-analysis
Cords O, Martinez L, Warren JL, O’Marr J, Walter KS, Cohen T, Zheng J, Ko AI, Croda J, Andrews JR. Incidence and prevalence of tuberculosis in incarcerated populations: a systematic review and meta-analysis. The Lancet Public Health 2021, 6: e300-e308. PMID: 33765455, PMCID: PMC8168455, DOI: 10.1016/s2468-2667(21)00025-6.Peer-Reviewed Original ResearchConceptsPrevalence of tuberculosisIncidence of tuberculosisM tuberculosis infectionIncidence rate ratiosTuberculosis infectionGeneral populationSystematic reviewSouth-East Asia RegionIncarcerated populationsPopulation-level incidenceMycobacterium tuberculosis infectionRate ratioTuberculosis Control ProgrammeLILACS electronic databasesWHO Eastern Mediterranean RegionWHO South-East Asia RegionWeb of KnowledgeCohort studyUS National InstitutesSubgroup analysisPooled estimatesHigh riskElectronic databasesPreventive interventionsTuberculosis
2020
Time Since Infection and Risks of Future Disease for Individuals with Mycobacterium tuberculosis Infection in the United States
Menzies NA, Swartwood N, Testa C, Malyuta Y, Hill AN, Marks SM, Cohen T, Salomon JA. Time Since Infection and Risks of Future Disease for Individuals with Mycobacterium tuberculosis Infection in the United States. Epidemiology 2020, 32: 70-78. PMID: 33009253, PMCID: PMC7707158, DOI: 10.1097/ede.0000000000001271.Peer-Reviewed Original ResearchConceptsLatent TB infectionMycobacterium tuberculosis infectionTB infectionTuberculosis infectionTB natural historyRisk of tuberculosisMost TB casesRate of progressionYounger age groupsLower future riskTransmission dynamic modelTB casesTB riskPrevalent infectionProgression riskLifetime riskRisk factorsIncidence trendsClinical diseaseCumulative riskGeneral populationAverage ageNew infectionsUS populationAge groups
2017
Drivers of Tuberculosis Transmission
Mathema B, Andrews JR, Cohen T, Borgdorff MW, Behr M, Glynn JR, Rustomjee R, Silk BJ, Wood R. Drivers of Tuberculosis Transmission. The Journal Of Infectious Diseases 2017, 216: s644-s653. PMID: 29112745, PMCID: PMC5853844, DOI: 10.1093/infdis/jix354.Peer-Reviewed Original ResearchConceptsRecent transmissionTuberculosis transmissionTuberculosis casesCulture-positive tuberculosis casesInterferon-γ release assaysΓ release assaysTuberculin skin testMycobacterium tuberculosis infectionTuberculosis case notificationTransmission of tuberculosisPublic health systemPrevalent tuberculosisTuberculosis infectionSkin testIncident diseaseCase notificationClinical diseaseHealth systemCapacity of healthcareOngoing transmissionTuberculosisYoung childrenHighlight knowledge gapsInfection eventsWhole-genome sequencing
2016
Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study
Cohen T, Chindelevitch L, Misra R, Kempner ME, Galea J, Moodley P, Wilson D. Within-Host Heterogeneity of Mycobacterium tuberculosis Infection Is Associated With Poor Early Treatment Response: A Prospective Cohort Study. The Journal Of Infectious Diseases 2016, 213: 1796-1799. PMID: 26768249, PMCID: PMC4857469, DOI: 10.1093/infdis/jiw014.Peer-Reviewed Original ResearchConceptsMonths of treatmentMycobacterium tuberculosis infectionTuberculosis infectionTreatment responsePoor early treatment responseProspective cohort studyInitiation of treatmentM. tuberculosis infectionRepetitive units-variable numberEarly treatment responsePersistent culture positivityCohort studyClinical managementCulture positivityHigher oddsInfectionTuberculosisPrevalenceTreatmentMonthsResponsePatientsKwaZulu-NatalHost heterogeneityPositivity
2012
Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control
Cohen T, van Helden PD, Wilson D, Colijn C, McLaughlin MM, Abubakar I, Warren RM. Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control. Clinical Microbiology Reviews 2012, 25: 708-719. PMID: 23034327, PMCID: PMC3485752, DOI: 10.1128/cmr.00021-12.Peer-Reviewed Original ResearchConceptsMixed infectionsTuberculosis infectionM. tuberculosis infectionTuberculosis control strategiesMycobacterium tuberculosis infectionTreatment of patientsMultiple distinct strainsTuberculosis treatmentInfectionMycobacterium tuberculosisEpidemiological importanceDistinct strainsTreatmentNumerous studiesPatientsTuberculosisDiagnosisHighlight challengesIndividualsModeling the Dynamic Relationship Between HIV and the Risk of Drug-Resistant Tuberculosis
Sergeev R, Colijn C, Murray M, Cohen T. Modeling the Dynamic Relationship Between HIV and the Risk of Drug-Resistant Tuberculosis. Science Translational Medicine 2012, 4: 135ra67. PMID: 22623743, PMCID: PMC3387814, DOI: 10.1126/scitranslmed.3003815.Peer-Reviewed Original ResearchConceptsMultidrug-resistant TBDrug-resistant tuberculosisDrug-resistant TBHIV-seropositive individualsHIV statusTB patientsLatent Mycobacterium tuberculosis infectionIndividual HIV statusIncident HIV infectionMultidrug-resistant tuberculosisMycobacterium tuberculosis infectionEffects of HIVCross-sectional studyDrug-resistant formsRise of HIVIndividual-level associationsAcquisition of resistanceAverage CD4HIV infectionResistance-conferring mutationsTB controlTuberculosis infectionResistant tuberculosisTB drugsHIV epidemic
2010
Mixed-Strain Mycobacterium tuberculosis Infections among Patients Dying in a Hospital in KwaZulu-Natal, South Africa
Cohen T, Wilson D, Wallengren K, Samuel EY, Murray M. Mixed-Strain Mycobacterium tuberculosis Infections among Patients Dying in a Hospital in KwaZulu-Natal, South Africa. Journal Of Clinical Microbiology 2010, 49: 385-388. PMID: 20980576, PMCID: PMC3020455, DOI: 10.1128/jcm.01378-10.Peer-Reviewed Original ResearchConceptsMycobacterium tuberculosis infectionCulture-positive samplesTuberculosis infectionBiopsy specimensClonal heterogeneityKwaZulu-NatalHospitalPatientsInfectionSpoligotyping
2006
Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV–tuberculosis coinfected populations
Cohen T, Lipsitch M, Walensky RP, Murray M. Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV–tuberculosis coinfected populations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 7042-7047. PMID: 16632605, PMCID: PMC1459015, DOI: 10.1073/pnas.0600349103.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyDrug-resistant TBCommunity-wide isoniazid preventive therapyPreventive therapyTuberculosis infectionTB controlLatent Mycobacterium tuberculosis infectionLatent tuberculosis infectionProportion of patientsMycobacterium tuberculosis infectionIncidence of TBTuberculosis case notificationCommunity-wide implementationEmergence of HIVCommunity-wide strategiesHIV-tuberculosisTB-HIVCoinfected individualsTB epidemicCase notificationTreatment policyHIVTherapyInfectionTB