2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancy
2023
Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study
Vollmar A, Rattray N, Cai Y, Jain A, Yan H, Deziel N, Calafat A, Wilcox A, Jukic A, Johnson C. Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environmental Health Perspectives 2023, 131: 097006. PMID: 37702489, PMCID: PMC10498870, DOI: 10.1289/ehp12125.Peer-Reviewed Original ResearchConceptsUrinary paraben concentrationsDiet-related metabolitesEarly Pregnancy StudyUrinary metabolomePregnancy StudyParaben concentrationsReproductive functionMultivariable linear regressionFemale reproductive functionDietary exposure assessmentUltrahigh-performance liquid chromatography-quadrupole timeMetabolomic analysisParaben exposureProspective cohortLiquid chromatography-quadrupole timeOrthogonal partial least squares discriminant analysisPericonceptional periodPotential confoundersUrinary concentrationsMetabolomic markersNutritional epidemiologyUnivariate statistical analysisExposure informationCritical windowUrine samplesResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metrics
2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive functionHemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study
Jain A, Morris M, Lin EZ, Khan SA, Ma X, Deziel NC, Godri Pollitt KJ, Johnson CH. Hemoglobin normalization outperforms other methods for standardizing dried blood spot metabolomics: A comparative study. The Science Of The Total Environment 2022, 854: 158716. PMID: 36113793, DOI: 10.1016/j.scitotenv.2022.158716.Peer-Reviewed Original ResearchUnconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsPrenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2021
Invited Perspective: Oil and Gas Development and Adverse Birth Outcomes: What More Do We Need to Know?
Deziel NC. Invited Perspective: Oil and Gas Development and Adverse Birth Outcomes: What More Do We Need to Know? Environmental Health Perspectives 2021, 129: 071301. PMID: 34287014, PMCID: PMC8312483, DOI: 10.1289/ehp9715.Peer-Reviewed Original ResearchExposure to atmospheric metals using moss bioindicators and neonatal health outcomes in Portland, Oregon
Comess S, Donovan G, Gatziolis D, Deziel NC. Exposure to atmospheric metals using moss bioindicators and neonatal health outcomes in Portland, Oregon. Environmental Pollution 2021, 284: 117343. PMID: 34030082, DOI: 10.1016/j.envpol.2021.117343.Peer-Reviewed Original Research
2020
Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women
Deziel NC, Warren JL, Huang H, Zhou H, Sjodin A, Zhang Y. Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women. Environmental Research 2020, 192: 110333. PMID: 33068584, PMCID: PMC7736223, DOI: 10.1016/j.envres.2020.110333.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerThyroid cancerPCBs/OCPsOdds ratioSubsequent thyroid cancer riskMulti-pollutant modelingSerum Polychlorinated BiphenylsBody mass indexConfidence intervalsThyroid cancer riskThyroid cancer incidenceEarly life exposureEnvironmental risk factorsSingle-pollutant modelsLogistic regression modelsIsotope dilution high-resolution mass spectrometryMass indexTumor sizeCancer incidenceRisk factorsConnecticut womenFamily historyMulti-pollutant analysisCancer riskThyroid hormone disruptorsBirth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesPrenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasmaAccounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling
Rosen Vollmar AK, Johnson CH, Weinberg CR, Deziel NC, Baird DD, Wilcox AJ, Jukic AMZ. Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling. Journal Of Exposure Science & Environmental Epidemiology 2020, 31: 356-365. PMID: 32424331, PMCID: PMC7671945, DOI: 10.1038/s41370-020-0227-1.Peer-Reviewed Original ResearchConceptsCreatinine adjustmentCreatinine concentrationUrinary dilutionUrinary estrogen metabolitesEffect of pregnancyUrinary creatinine concentrationCreatinine levelsWeeks' gestationEarly pregnancyCreatinine excretionEstrogen metabolitesCreatinine measuresUrine specimensPooled measureBiomarker measurementsPooled specimensEnvironmental exposuresExposure measuresLinear mixed modelsBiomonitoring resultsPregnancyT-testKappa coefficientMixed modelsPerson sampleZinc Levels and Birth Weight in Pregnant Women with Gestational Diabetes Mellitus: A Matched Cohort Study in China
Luo J, Wu W, Zhang P, Chen X, Feng Y, Ma N, Yang H, Wang Y, Li M, Xie B, Guo P, Liew Z, Deziel NC, Vasiliou V, Shi X, Wang S, Zhang Y. Zinc Levels and Birth Weight in Pregnant Women with Gestational Diabetes Mellitus: A Matched Cohort Study in China. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa171. PMID: 32285111, DOI: 10.1210/clinem/dgaa171.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBirth weightMaternal bloodDiabetes mellitusFetal growthZn intakeMatched Cohort StudyZn levelsDietary Zn intakeCohort studyPregnant womenPlacental transportMultinomial logistic regressionZ-scoreZinc levelsLogistic regressionAdverse effectsWomenMellitusPregnancyLow groupInadequate ZnSuggestive associationAssociationIntakeDioxin exposure and breast cancer risk in a prospective cohort study
VoPham T, Bertrand KA, Jones RR, Deziel NC, DuPré NC, James P, Liu Y, Vieira VM, Tamimi RM, Hart JE, Ward MH, Laden F. Dioxin exposure and breast cancer risk in a prospective cohort study. Environmental Research 2020, 186: 109516. PMID: 32305677, PMCID: PMC7363533, DOI: 10.1016/j.envres.2020.109516.Peer-Reviewed Original ResearchConceptsNurses' Health Study IIBreast cancer riskInvasive breast cancer riskHealth Study IICancer riskDioxin exposureHazard ratioBreast cancer risk factorsInvasive breast cancer casesInvasive breast cancer diagnosisER- breast cancerMedical record reviewProspective cohort studyCancer risk factorsConfidence intervalsBreast cancer casesResidential proximityGeocoded residential addressesPositive associationBreast cancer diagnosisBiennial questionnairesCohort studyMenopausal statusRecord reviewRisk factorsAssessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls
Howland RE, Deziel NC, Bentley GR, Booth M, Choudhury OA, Hofmann JN, Hoover RN, Katki HA, Trabert B, Fox SD, Troisi R, Houghton LC. Assessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls. International Journal Of Environmental Research And Public Health 2020, 17: 1185. PMID: 32069802, PMCID: PMC7068451, DOI: 10.3390/ijerph17041185.Peer-Reviewed Original ResearchConceptsEstrogen metabolitesBPA-glucuronideBreast developmentMigrant studiesBreast cancer incidenceEndogenous estrogen levelsBisphenol A (BPA) exposureExogenous hormone exposureCross-sectional studyBangladeshi girlsTime of interviewUrine spot samplesHazard ratioEstrogen levelsA ExposureCancer incidenceEarlier thelarcheTanner stageUbiquitous exposureHormone exposureThelarcheLiquid chromatography-tandem mass spectrometryConfidence intervalsWhite BritishAdolescent girlsA Multiregion Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States
Johnson NP, Warren JL, Elliott EG, Niccolai LM, Deziel NC. A Multiregion Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States. Sexually Transmitted Diseases 2020, 47: 254-260. PMID: 32168285, PMCID: PMC7077974, DOI: 10.1097/olq.0000000000001127.Peer-Reviewed Original ResearchUnconventional oil and gas development and health outcomes: A scoping review of the epidemiological research
Deziel NC, Brokovich E, Grotto I, Clark CJ, Barnett-Itzhaki Z, Broday D, Agay-Shay K. Unconventional oil and gas development and health outcomes: A scoping review of the epidemiological research. Environmental Research 2020, 182: 109124. PMID: 32069745, DOI: 10.1016/j.envres.2020.109124.Peer-Reviewed Original ResearchConceptsHealth outcomesLow birth weightAdverse birth outcomesAdverse health outcomesFull-text evaluationOutcomes of interestHuman health outcomesAsthma exacerbationsPreterm deliveryPregnancy outcomesBirth outcomesPotential confoundersBirth weightBody of evidenceCancer incidenceEligible studiesExposure assessment methodologyPotential environmental health hazardInclusion criteriaStudy populationEpidemiological studiesExposure assessment approachHealth problemsEnvironmental health hazardsSignificant association
2019
Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population-based case-control study in Connecticut
Luo J, Li H, Deziel NC, Huang H, Zhao N, Ma S, Ni X, Udelsman R, Zhang Y. Genetic susceptibility may modify the association between cell phone use and thyroid cancer: A population-based case-control study in Connecticut. Environmental Research 2019, 182: 109013. PMID: 31918310, PMCID: PMC7061309, DOI: 10.1016/j.envres.2019.109013.Peer-Reviewed Original ResearchExposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches
Deziel NC, Alfonso-Garrido J, Warren JL, Huang H, Sjodin A, Zhang Y. Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches. Cancer Epidemiology Biomarkers & Prevention 2019, 28: 1755-1764. PMID: 31387967, PMCID: PMC6774868, DOI: 10.1158/1055-9965.epi-19-0526.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerThyroid cancerPTC riskLipid-adjusted serum concentrationsPapillary thyroid cancer casesMulti-pollutant approachSerum samplesMulti-pollutant modelingThyroid cancer incidenceInterquartile range increaseThyroid cancer casesMulti-pollutant modelsSingle-pollutant modelsLogistic regression modelsPBB exposureDecreased riskProspective studySerum concentrationsCancer incidenceCancer casesAlcohol consumptionFemale controlsLow categoryConfidence intervalsPBB mixture