Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice
Wang T, Li H, Li Y, Li M, Zhao H, Zhang W, Zhao T, Wang Y, Wang J, Wang J. Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice. The Science Of The Total Environment 2024, 951: 175458. PMID: 39142410, DOI: 10.1016/j.scitotenv.2024.175458.Peer-Reviewed Original ResearchParkin-mediated mitophagyCysteinyl aspartate specific proteinase 3Protein expression levelsLight chain 3Expression levelsInterleukin-6Wild-typeLiver damageContents of proinflammatory factorsTumor necrosis factor-aNuclear factor kappa BLevels of liver functionMitochondrial fusionFactor kappa BParkin-/-Inflammatory signaling pathwaysMicrotubule-associated protein light chain 3MitophagyInterferon-gMitochondrial alterationsProtein light chain 3Gene knockoutIFN-gFluorosis miceLiver functionCalcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice
Hu Y, Li Y, Li M, Zhao T, Zhang W, Wang Y, He Y, Zhao H, Li H, Wang T, Zhao Y, Wang J, Wang J. Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice. Journal Of Hazardous Materials 2024, 465: 133411. PMID: 38181596, DOI: 10.1016/j.jhazmat.2023.133411.Peer-Reviewed Original ResearchCalcium supplementationBone injuryBone damageFluoride-exposed miceParkin knockout miceSkeletal fluorosisMitochondrial apoptosisImpairment of mitochondriaTherapy of animalsBone disordersMouse modelFluoride exposureKnockout micePINK1/Parkin-mediated mitophagyNovel targetInjuryBone trabeculaeMiceParkin-mediated mitophagyPrecise mechanismProvide protectionApoptosisExcessive consumptionSupplementationPINK1/Parkin pathway