Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice
Hu Y, Li Y, Li M, Zhao T, Zhang W, Wang Y, He Y, Zhao H, Li H, Wang T, Zhao Y, Wang J, Wang J. Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice. Journal Of Hazardous Materials 2024, 465: 133411. PMID: 38181596, DOI: 10.1016/j.jhazmat.2023.133411.Peer-Reviewed Original ResearchCalcium supplementationBone injuryBone damageFluoride-exposed miceParkin knockout miceSkeletal fluorosisMitochondrial apoptosisImpairment of mitochondriaTherapy of animalsBone disordersMouse modelFluoride exposureKnockout micePINK1/Parkin-mediated mitophagyNovel targetInjuryBone trabeculaeMiceParkin-mediated mitophagyPrecise mechanismProvide protectionApoptosisExcessive consumptionSupplementationPINK1/Parkin pathway