2017
Antimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers
Kunkel A, Lewnard JA, Pitzer VE, Cohen T. Antimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers. Antimicrobial Agents And Chemotherapy 2017, 61: 10.1128/aac.00026-17. PMID: 28533237, PMCID: PMC5527623, DOI: 10.1128/aac.00026-17.Peer-Reviewed Original ResearchConceptsDrug-resistant infectionsAntimicrobial chemoprophylaxisDrug-sensitive infectionsDrug resistance generationCholera importationChemoprophylaxisDrug resistanceImportation eventsInfectionAntibiotic resistanceAntimicrobial resistance risksRiskRelative benefitsResistance generationCholeraPotential resistance risksPotential benefitsResistance riskProphylaxisPrevalence
2015
Classic reaction kinetics can explain complex patterns of antibiotic action
Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T. Classic reaction kinetics can explain complex patterns of antibiotic action. Science Translational Medicine 2015, 7: 287ra73. PMID: 25972005, PMCID: PMC4554720, DOI: 10.1126/scitranslmed.aaa8760.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsEscherichia coliKineticsMicrobial Sensitivity TestsVibrio choleraeConceptsOptimal dosing strategiesAntibiotic treatment strategiesTime-kill curvesAntibiotic effectGrowth suppressionCell formationChemotherapeutic regimensClinical trialsDosing strategiesTreatment strategiesTuberculosis therapyPersister cell formationDrug effectsBacterial infectionsVariety of antibiotics