2016
High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions
Marx FM, Floyd S, Ayles H, Godfrey-Faussett P, Beyers N, Cohen T. High burden of prevalent tuberculosis among previously treated people in Southern Africa suggests potential for targeted control interventions. European Respiratory Journal 2016, 48: 1227-1230. PMID: 27390274, PMCID: PMC5512114, DOI: 10.1183/13993003.00716-2016.Peer-Reviewed Original ResearchConceptsHigh-burden settingsHigh TB prevalenceRecurrent tuberculosisExogenous reinfectionPrevalent tuberculosisTB prevalenceSuccessful treatmentHigh burdenImportant underlying mechanismHigh riskHigh incidenceControl interventionsTargeted interventionsTuberculosisUnderlying mechanismOne-thirdInterventionBurdenCape TownIndividualsReinfectionPrevalenceIncidenceDiseaseSetting
2014
Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection
Plazzotta G, Cohen T, Colijn C. Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection. Journal Of Theoretical Biology 2014, 368: 67-73. PMID: 25553967, PMCID: PMC7011203, DOI: 10.1016/j.jtbi.2014.12.009.Peer-Reviewed Original ResearchConceptsMixed infectionsM. tuberculosis infectionIncidence of TBOutcome of treatmentPopulation-level interventionsFraction of casesTuberculosis infectionMinority strainsActual prevalenceInfected individualsInfectionStudy designMycobacterium tuberculosisPrevalenceSputumTuberculosisDistinct strainsDifferent strainsSources of biasPrevious studiesPatientsSpecific reasonsIncidenceIndividuals
2012
Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control
Cohen T, van Helden PD, Wilson D, Colijn C, McLaughlin MM, Abubakar I, Warren RM. Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control. Clinical Microbiology Reviews 2012, 25: 708-719. PMID: 23034327, PMCID: PMC3485752, DOI: 10.1128/cmr.00021-12.Peer-Reviewed Original ResearchConceptsMixed infectionsTuberculosis infectionM. tuberculosis infectionTuberculosis control strategiesMycobacterium tuberculosis infectionTreatment of patientsMultiple distinct strainsTuberculosis treatmentInfectionMycobacterium tuberculosisEpidemiological importanceDistinct strainsTreatmentNumerous studiesPatientsTuberculosisDiagnosisHighlight challengesIndividuals