1989
Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I
Mathis J, Houser W, Bresnick E, Cidlowski J, Hines R, Prough R, Simpson E. Glucocorticoid regulation of the rat cytochrome P450c (P450IA1) gene: Receptor binding within intron I. Archives Of Biochemistry And Biophysics 1989, 269: 93-105. PMID: 2916850, DOI: 10.1016/0003-9861(89)90090-8.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorConcentrations of dexamethasoneUntreated cellsMRNA contentFetal rat hepatocytesHalf-maximal increaseAddition of dexamethasonePresence of dexamethasoneCultured fetal rat hepatocytesGlucocorticoid-responsive elementRat hepatocytesDexamethasoneCytochrome P450cGlucocorticoid regulationHepG2 hepatoma cellsGlucocorticoidsAcetyltransferase activityHepatic cytochromeChloramphenicol acetyltransferase activityReceptorsNorthern blot analysisBlot analysisHepatoma cellsReceptor fraction
1986
Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes
Mathis J, Prough R, Hines R, Bresnick E, Simpson E. Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Archives Of Biochemistry And Biophysics 1986, 246: 439-448. PMID: 2870681, DOI: 10.1016/0003-9861(86)90490-x.Peer-Reviewed Original Research
1985
Implication of the "4S" polycyclic aromatic hydrocarbon binding protein in the transregulation of rat cytochrome P-450c expression.
Houser W, Hines R, Bresnick E. Implication of the "4S" polycyclic aromatic hydrocarbon binding protein in the transregulation of rat cytochrome P-450c expression. Biochemistry 1985, 24: 7839-45. PMID: 4092041, DOI: 10.1021/bi00347a050.Peer-Reviewed Original Research3-Methylcholanthrene-induced expression of the cytochrome P-450c gene
Foldes R, Hines R, Ho K, Shen M, Nagel K, Bresnick E. 3-Methylcholanthrene-induced expression of the cytochrome P-450c gene. Archives Of Biochemistry And Biophysics 1985, 239: 137-146. PMID: 4004253, DOI: 10.1016/0003-9861(85)90820-3.Peer-Reviewed Original ResearchConceptsNuclear RNA speciesCytochrome P-450c mRNARNA speciesCytochrome P-450c geneP-450c geneClone 46Nuclear transcription systemNuclear RNA precursorsNuclear RNA transportRat serum albumin geneDot hybridization experimentsSerum albumin geneNorthern blot analysisTranscriptional controlRNA transportRNA precursorsNuclear RNARegulation of inductionHybridization experimentsTranscription systemM13 subclonesAlbumin geneCytochrome P-450cRNA inductionSpecies
1984
Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo[a]pyrene by thin-layer chromatography
Raha C, Hines R, Bresnick E. Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo[a]pyrene by thin-layer chromatography. Journal Of Chromatography 1984, 291: 231-239. PMID: 6539786, DOI: 10.1016/s0021-9673(00)95024-6.Peer-Reviewed Original Research
1983
Molecular induction by phenobarbital of a rat hepatic form of cytochrome P-450: Expression of a 4-kilobase messenger RNA
Omiecinski C, Hines R, Foldes R, Levy J, Bresnick E. Molecular induction by phenobarbital of a rat hepatic form of cytochrome P-450: Expression of a 4-kilobase messenger RNA. Archives Of Biochemistry And Biophysics 1983, 227: 478-493. PMID: 6141764, DOI: 10.1016/0003-9861(83)90478-2.Peer-Reviewed Original Research
1982
Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line p815) cells
Wiebkin P, Sieg M, Nelson R, Hines R, Prough R. Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line p815) cells. Biochemical Pharmacology 1982, 31: 2921-2928. PMID: 6814447, DOI: 10.1016/0006-2952(82)90264-7.Peer-Reviewed Original Research
1981
The molecular cloning of cytochrome P-450c information
Bresnick E, Levy J, Hines R, Levin W, Thomas P. The molecular cloning of cytochrome P-450c information. Archives Of Biochemistry And Biophysics 1981, 212: 501-507. PMID: 7034652, DOI: 10.1016/0003-9861(81)90393-3.Peer-Reviewed Original ResearchInhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815).
Wiebkin P, Hines R, Nelson R, Prough R. Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815). 1981, 136 Pt B: 1067-75. PMID: 7344500.Peer-Reviewed Original Research