2020
Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals
Burman A, Garcia-Milian R, Whirledge S. Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals. Human Genomics 2020, 14: 19. PMID: 32448403, PMCID: PMC7247264, DOI: 10.1186/s40246-020-00269-1.Peer-Reviewed Original ResearchConceptsTranscriptional responseCellular environmentCellular contextGenetic sexUnique gene networksGene regulatory networksEnvironment interactionEnvironmental chemicalsGene expression studiesUnique transcriptional profileGene expression array dataExpression array dataPhenotype of cellsGene networksRegulatory networksTranscriptional profilesBiological functionsCellular organizationExpression studiesFemale cellsCellular responsesPhysiological cuesHuman gene expression studiesMolecular pathwaysGenetic results
2017
Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease
Guo X, Qiu W, Garcia-Milian R, Lin X, Zhang Y, Cao Y, Tan Y, Wang Z, Shi J, Wang J, Liu D, Song L, Xu Y, Wang X, Liu N, Sun T, Zheng J, Luo J, Zhang H, Xu J, Kang L, Ma C, Wang K, Luo X. Genome-wide significant, replicated and functional risk variants for Alzheimer’s disease. Journal Of Neural Transmission 2017, 124: 1455-1471. PMID: 28770390, PMCID: PMC5654670, DOI: 10.1007/s00702-017-1773-0.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesNon-coding RNAsRisk variantsRisk genesProtein-coding genesProtein-coding RNAsLong non-coding RNAsFunctional risk variantsPotential biological functionsAD-related pathwaysExpression of piRNAsAlterations of proteinsGenomic regionsExpression correlationBiological functionsProtein structureAssociation studiesMetabolism pathwaysLipoprotein metabolism pathwaysRisk SNPsGenesSNPsPiRNAsRNARegulatory effects