The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R, Baker VL, Santoro N, Steiner AZ. The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Journal Of Assisted Reproduction And Genetics 2021, 38: 3005-3013. PMID: 34455507, PMCID: PMC8609082, DOI: 10.1007/s10815-021-02301-2.Peer-Reviewed Original ResearchConceptsPlasma antioxidant levelsLive birthsClinical trialsSemen parametersAntioxidant levelsVitamin ERank sum testSecondary analysisClinical outcomesNormal rangeBaseline plasma valuesVitamin E levelsWilcoxon rank sum testMale fertilityConclusionsAmong menPrimary endpointDNA fragmentationResultsAt baselineSerum levelsFertility centerE levelsMethodsThis studyMale infertilityFertility outcomesPlasma valuesMale vitamin D status and male factor infertility
Banks N, Sun F, Krawetz SA, Coward RM, Masson P, Smith JF, Trussell JC, Santoro N, Zhang H, Steiner AZ. Male vitamin D status and male factor infertility. Fertility And Sterility 2021, 116: 973-979. PMID: 34289935, PMCID: PMC8561776, DOI: 10.1016/j.fertnstert.2021.06.035.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultBiomarkersClomipheneDietary SupplementsDouble-Blind MethodFemaleFertilityFertility Agents, FemaleHumansInfertility, MaleInsemination, Artificial, HomologousLive BirthMalePregnancyPregnancy RateProspective StudiesRisk FactorsSemenSemen AnalysisTime FactorsTreatment OutcomeUnited StatesVitamin DVitamin D DeficiencyConceptsVitamin D deficiencyLive birth rateMale factor infertilityD deficiencyFactor infertilityD levelsSemen parametersMild male factor infertilityMale partnersVitamin D levelsVitamin D statusRate of miscarriageFemale partnersSperm concentrationBirth rateClinical pregnancyClomiphene citrateD statusDNA fragmentationCumulative pregnancySperm DNA fragmentationVitamin DFertility centerIntrauterine inseminationMonth 4