2022
Biomarkers of Stress and Male Fertility
Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Diamond MP, Krawetz SA, Sun F, Zhang H, Santoro N, Steiner AZ. Biomarkers of Stress and Male Fertility. Reproductive Sciences 2022, 29: 1262-1270. PMID: 35106743, PMCID: PMC9078052, DOI: 10.1007/s43032-022-00853-x.Peer-Reviewed Original ResearchConceptsLive birth rateSemen parametersSalivary levelsSperm countPregnancy/live birth rateBirth rateTotal motile sperm countMale factor infertilityMotile sperm countDNA fragmentationTotal sperm countSalivary cortisol levelsMale fertilityStress-related biomarkersChi-square testingSalivary alpha-amylaseInfertility trialsCohort studyHighest quintileIntrauterine inseminationPregnancy rateUpper quintileInfertile menPhysiologic measuresBiomarkers of stress
2021
Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males
Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ. Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males. F&S Reports 2021, 2: 282-288. PMID: 34553152, PMCID: PMC8441563, DOI: 10.1016/j.xfre.2021.06.003.Peer-Reviewed Original ResearchPregnancy outcomesInfertile menSperm deoxyribonucleic acid fragmentationMultivariable linear regression modelsTransferase-mediated dUTP nickDeoxyribonucleic acid fragmentationLower total sperm motilityOvarian stimulationBaseline visitFertility centerTubal patencyIntrauterine inseminationLive birthsFertility outcomesInfertile malesSecondary analysisOlder ageDUTP nickFemale partnersSpearman correlationSperm concentrationSignificant predictorsTotal sperm motilityModest correlationMen