Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males
Rios JS, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Sun F, Wild R, Smith JF, Santoro N, Zhang H, Steiner AZ. Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males. F&S Reports 2021, 2: 282-288. PMID: 34553152, PMCID: PMC8441563, DOI: 10.1016/j.xfre.2021.06.003.Peer-Reviewed Original ResearchPregnancy outcomesInfertile menSperm deoxyribonucleic acid fragmentationMultivariable linear regression modelsTransferase-mediated dUTP nickDeoxyribonucleic acid fragmentationLower total sperm motilityOvarian stimulationBaseline visitFertility centerTubal patencyIntrauterine inseminationLive birthsFertility outcomesInfertile malesSecondary analysisOlder ageDUTP nickFemale partnersSpearman correlationSperm concentrationSignificant predictorsTotal sperm motilityModest correlationMen