2014
The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures
Morishita M, Bard R, Wang L, Das R, Dvonch J, Spino C, Mukherjee B, Sun Q, Harkema J, Rajagopalan S, Brook R. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal Of Exposure Science & Environmental Epidemiology 2014, 25: 153-159. PMID: 25227729, PMCID: PMC4462122, DOI: 10.1038/jes.2014.62.Peer-Reviewed Original ResearchConceptsCoarse PMPM massEffects of coarse PMCoarse PM massAmbient coarse PMRural locationsSystolic BPMetrics of exposureBlood pressurePotential health effectsHeart ratePM elementsElevated systolic BPFiltered airAerodynamic diameterDiastolic BP changesMixed model analysisConcentration-response mannerParticulate massFilter samplesParticle constituentsDiastolic BPMeasured elementsHealthy adultsAssociated with similar degreesHemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location
Brook R, Bard R, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Kaplan M, Yalavarthi S, Oral E, Ajluni N, Sun Q, Brook J, Harkema J, Rajagopalan S. Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location. Environmental Health Perspectives 2014, 122: 624-630. PMID: 24618231, PMCID: PMC4050508, DOI: 10.1289/ehp.1306595.Peer-Reviewed Original ResearchConceptsCoarse PMParticulate matterAir pollutionRural locationsCoarse particlesParticulate matter air pollutionCoarse PM exposureAssociated with numerous adverse health effectsAcute CV eventsBlood pressureFine particulate matterAmbient coarse particlesNumerous adverse health effectsGlobal air pollutionAdverse health effectsHeart rateFrequency heart rate variabilityCoarse CAPPM exposureFiltered airRandomized double-blind crossover studyDiastolic BPDouble-blind crossover studyHealth effectsHealthy adultsNo effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function
Maiseyeu A, Yang H, Ramanathan G, Yin F, Bard R, Morishita M, Dvonch J, Wang L, Spino C, Mukherjee B, Badgeley M, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo J, Brook R. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014, 26: 23-29. PMID: 24417404, PMCID: PMC4445365, DOI: 10.3109/08958378.2013.850761.Peer-Reviewed Original ResearchConceptsRural locationsParticulate matter air pollutionHDL dysfunctionHDL anti-oxidative capacityRandomized double-blind crossover studyDouble-blind crossover studyHDL functionHDL-mediated cholesterol efflux capacityParaoxonase activityFiltered airVascular protective functionCholesterol efflux capacityHigh-density lipoprotein (HDL) particlesMetrics of HDL functionHDL-mediated effluxConcentrated ambient particlesCrossover studyImpact of PMEfflux capacityPM exposureVenous bloodAnimal studiesHealthy humansCoarse PMWilcoxon test
2013
The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
Brook R, Bard R, Kaplan M, Yalavarthi S, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Oral E, Sun Q, Brook J, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013, 25: 587-592. PMID: 23919441, PMCID: PMC4364610, DOI: 10.3109/08958378.2013.814733.Peer-Reviewed Original ResearchConceptsCirculating endothelial progenitor cellsRural locationsVascular endothelial growth factorEndothelial progenitor cellsCirculating EPC levelsCoarse PMWhite blood cellsParticulate matterConcentrated ambient particlesParticulate matter air pollutionAir pollutionFine particulate matterEPC levelsProgenitor cellsWilcoxon signed-rank testRandomized double-blind crossover studyDouble-blind crossover studyFiltered airSigned-rank testBlood cellsPeripheral venous bloodSympathetic nervous system activityEndothelial growth factorAssociated with alterationsCardiovascular disease
2012
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
Lewis T, Robins T, Mentz G, Zhang X, Mukherjee B, Lin X, Keeler G, Dvonch J, Yip F, O'Neill M, Parker E, Israel B, Max P, Reyes A, Committee C. Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area. The Science Of The Total Environment 2012, 448: 48-55. PMID: 23273373, PMCID: PMC4327853, DOI: 10.1016/j.scitotenv.2012.11.070.Peer-Reviewed Original ResearchConceptsParticulate matterAir pollutionAssociated with negative health impactsAmbient pollutant concentrationsAir quality standardsAmbient air pollutionAmbient particulate matterEffective risk reduction interventionsOdds of respiratory symptomsAsthmatic childrenFactors associated with heterogeneityAssociated with increased oddsObserved health effectsRespiratory symptomsRisk reduction interventionsPopulation of asthmatic childrenRespiratory symptom diariesOutdoor PMDaily concentrationsPollutant concentrationsMonitoring sitesGeneralized estimating equationsPollution modelLogistic regression modelsAerodynamic diameter
2011
Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects
Li S, Batterman S, Wasilevich E, Wahl R, Wirth J, Su F, Mukherjee B. Association of daily asthma emergency department visits and hospital admissions with ambient air pollutants among the pediatric Medicaid population in Detroit: Time-series and time-stratified case-crossover analyses with threshold effects. Environmental Research 2011, 111: 1137-1147. PMID: 21764049, DOI: 10.1016/j.envres.2011.06.002.Peer-Reviewed Original ResearchConceptsAmbient air pollutionGeneralized additive modelCase-crossover designConditional logistic regressionPediatric Medicaid populationAir pollutionAsthma morbidityAssociated with ambient air pollutionMedicaid populationEffects of air pollutionAsthma emergency department visitsAdditive modelLogistic regressionConditional logistic regression modelsAcute asthma eventsAssociations of SO2Interquartile range increaseCase-crossover analysisEmergency department visitsCase-crossover studyPM2.5 concentrationsPM2.5 thresholdLogistic regression modelsStrong effect sizesPM2.5PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio
Kamal A, Rohr A, Mukherjee B, Morishita M, Keeler G, Harkema J, Wagner J. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011, 23: 417-430. PMID: 21639710, DOI: 10.3109/08958378.2011.580387.Peer-Reviewed Original ResearchConceptsNE windsSW windsSource factorsMobile source factorsPositive matrix factorizationConcentrated ambient particlesPotential emission sourcesSources of PM(2.5Adverse health effectsPM constituentsWind directionParticulate matterMobile sourcesIndividual elemental componentsTrace elementsAmbient particlesIron/steel productionPM(2.5IncinerationAmbient PM(2.5Metal factorWindHealth effectsExposure to concentrated ambient particlesSouthwest