2022
Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals
Fang Y, Fritsche L, Mukherjee B, Sen S, Richmond-Rakerd L. Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals. Biological Psychiatry 2022, 92: 923-931. PMID: 35965108, PMCID: PMC10712651, DOI: 10.1016/j.biopsych.2022.06.004.Peer-Reviewed Original ResearchConceptsPhenome-wide association studyPolygenic risk scoresMDD PRSHealth recordsRisk scoreAssociation studiesGenome-wide polygenic risk scoreAssociated with multiple medical conditionsMeasures of genetic riskMichigan Genomics InitiativePsychiatric traitsElectronic health recordsEuropean ancestry participantsMajor depressive disorderAssociated with tobacco use disorderTests of associationMultiple medical conditionsGenitourinary conditionsTobacco use disorderDisease-associated disabilityMolecular genetic toolsMolecular genetic discoveriesPsychiatric disease categoriesHealth outcomesSubstance-related disordersDepression, Anxiety, and Patterns of Mental Health Care Among Men With Prostate Cancer Receiving Androgen Deprivation Therapy
Tsao P, Ross R, Bohnert A, Mukherjee B, Caram M. Depression, Anxiety, and Patterns of Mental Health Care Among Men With Prostate Cancer Receiving Androgen Deprivation Therapy. The Oncologist 2022, 27: 314-322. PMID: 35298660, PMCID: PMC8982372, DOI: 10.1093/oncolo/oyab033.Peer-Reviewed Original ResearchMeSH KeywordsAndrogen AntagonistsAndrogensAnxietyDepressionHumansMaleMental HealthProstatic NeoplasmsConceptsAndrogen deprivation therapyMental health careProstate cancerMental health treatmentDiagnosis of depressionHealth careOptum's de-identified Clinformatics Data Mart DatabaseProstate cancer treated with androgen deprivation therapyInitiation of androgen deprivation therapyHealth treatmentPatterns of mental health careClinformatics Data Mart DatabaseSerotonin reuptake inhibitorsAnxiety diagnosesPsychotropic medicationsSpecialty of providersData Mart DatabasePrimary care physiciansPrescribing of psychotropic medicationsIncidence of depressionProportion of menDeprivation therapyReuptake inhibitorsMedian timeProstate
2020
Methods to Account for Uncertainty in Latent Class Assignments When Using Latent Classes as Predictors in Regression Models, with Application to Acculturation Strategy Measures.
Elliott M, Zhao Z, Mukherjee B, Kanaya A, Needham B. Methods to Account for Uncertainty in Latent Class Assignments When Using Latent Classes as Predictors in Regression Models, with Application to Acculturation Strategy Measures. Epidemiology 2020, 31: 194-204. PMID: 31809338, PMCID: PMC7480960, DOI: 10.1097/ede.0000000000001139.Peer-Reviewed Original ResearchConceptsMeasurement error modelJoint modelRegression parametersLatent classesLikelihood-basedLatent class modelSimulation studyClass modelTwo-stage modelClassError modelPrimary interestAcculturation behaviorsMeasurement errorSouth Asian immigrantsLatent class analysisAsian immigrantsTrue classUncertaintyClass analysisEstimationStrategy measures
2017
Acculturation Strategies and Symptoms of Depression: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Needham B, Mukherjee B, Bagchi P, Kim C, Mukherjea A, Kandula N, Kanaya A. Acculturation Strategies and Symptoms of Depression: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Journal Of Immigrant And Minority Health 2017, 20: 792-798. PMID: 28748299, PMCID: PMC5785586, DOI: 10.1007/s10903-017-0635-z.Peer-Reviewed Original ResearchConceptsSymptoms of depressionDepressive symptomsUS cultureSouth Asian immigrantsAcculturation strategiesElevated symptoms of depressionSocial supportSelf-reported social supportUndertreated mental disordersCES-D scaleAsian immigrantsSouth Asian culturesElevated symptomsLatent class analysisMental disordersCES-DIntegrated classesSouth AsiansMediators of AtherosclerosisAsian culturesDepressionLatent classesClass analysisAcculturationSymptoms
2015
Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis
Ware E, Mukherjee B, Sun Y, Diez-Roux A, Kardia S, Smith J. Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis. BMC Genomic Data 2015, 16: 118. PMID: 26459564, PMCID: PMC4603946, DOI: 10.1186/s12863-015-0274-0.Peer-Reviewed Original ResearchConceptsMulti-Ethnic StudyGenome-wide association studiesStudies of depressive symptomsMulti-Ethnic Study of AtherosclerosisDepressive symptomsStudy of AtherosclerosisGenome-wide suggestive levelMeasures analysisSingle-nucleotide polymorphismsMultiple ethnicitiesBaseline measurementsMeta-analysisEuropean AmericansLongitudinal measurementsGenome-wide analysisLongitudinal frameworkSuggestive levelAssociation studiesMethodsThis studyEthnicityGenetic predictorsP-valueMood disordersHealthNovel variantsApplying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis
Ware E, Smith J, Mukherjee B, Lee S, Kardia S, Diez-Roux A. Applying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis. Behavior Genetics 2015, 46: 89-99. PMID: 26254610, PMCID: PMC4720563, DOI: 10.1007/s10519-015-9734-6.Peer-Reviewed Original ResearchConceptsDepressive symptom scoresMulti-Ethnic Study of AtherosclerosisGene regionNeighborhood levelMulti-Ethnic StudyPredictive of depressive symptomsStudy of AtherosclerosisMultiple race/ethnicitiesMultiple testing correctionAssess individual-SKAT analysisNeighborhood factorsEtiology of depressive illnessDepressive symptomsPsychosocial stressorsSymptom scoresComplex illnessTesting correctionRace/ethnicityRace/ethnicitiesEthnic groupsDepressive illnessGenetic predispositionIndividual-Genetic factors