2017
Robust distributed lag models using data adaptive shrinkage
Chen Y, Mukherjee B, Adar S, Berrocal V, Coull B. Robust distributed lag models using data adaptive shrinkage. Biostatistics 2017, 19: 461-478. PMID: 29040386, PMCID: PMC6454578, DOI: 10.1093/biostatistics/kxx041.Peer-Reviewed Original ResearchConceptsDistributed lag modelsDistributed LagLag modelTime series dataEffects of air pollutionBias-variance trade-offGeneralized ridge regressionShrinkage methodAir pollution studiesHierarchical Bayes approachShrinkage approachTime seriesDl functionAir pollutionPollution studiesEffect estimatesTrade-offsExtensive simulation studyDependent variableShrinking coefficientsMean square errorLagSimulation studyBayes approachRidge regressionExposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction
Sun Z, Mukherjee B, Estes J, Vokonas P, Park S. Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction. Statistics In Medicine 2017, 36: 2947-2960. PMID: 28497531, PMCID: PMC5523112, DOI: 10.1002/sim.7332.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyCase-only designLongitudinal studyG x E interactionNormative Aging StudyComplete-case analysisGene-environmentSampling designCase-controlVeterans AdministrationComplex human diseasesE interactionExposure informationAging StudyOutcome trajectoriesStratified samplingRetrospective genotypingIndividual exposureCovariate dataExposure effectsJoint effectsOutcomesTime-varying outcomeEnvironmental factors
2014
Latent variable models for gene–environment interactions in longitudinal studies with multiple correlated exposures
Tao Y, Sánchez B, Mukherjee B. Latent variable models for gene–environment interactions in longitudinal studies with multiple correlated exposures. Statistics In Medicine 2014, 34: 1227-1241. PMID: 25545894, PMCID: PMC4355187, DOI: 10.1002/sim.6401.Peer-Reviewed Original ResearchMeSH KeywordsBiostatisticsChild, PreschoolComputer SimulationEnvironmental ExposureFemaleGene-Environment InteractionHemochromatosis ProteinHistocompatibility Antigens Class IHumansInfantInfant, NewbornLead PoisoningLongitudinal StudiesMembrane ProteinsMexicoModels, GeneticModels, StatisticalPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsConceptsGene-environment interactionsOutcome measuresCohort studyHealth effects of environmental exposuresEnvironmental exposuresInvestigate health effectsGene-environment associationsEffects of environmental exposuresEarly life exposuresLV frameworkG x E effectsMultivariate exposuresGenotyped single nucleotide polymorphismsEffect modificationShrinkage estimatorsLife exposureExposure measurementsSingle nucleotide polymorphismsData-adaptive wayMultiple testingOutcome dataLongitudinal studyLongitudinal natureGenetic factorsNucleotide polymorphisms
2012
Incorporating auxiliary information for improved prediction in high-dimensional datasets: an ensemble of shrinkage approaches
Boonstra P, Taylor J, Mukherjee B. Incorporating auxiliary information for improved prediction in high-dimensional datasets: an ensemble of shrinkage approaches. Biostatistics 2012, 14: 259-272. PMID: 23087411, PMCID: PMC3590922, DOI: 10.1093/biostatistics/kxs036.Peer-Reviewed Original ResearchConceptsHigh-dimensional datasetsAuxiliary informationRidge estimatorBayesian alternativeOutcome YSimulation studyEstimates of BShrinkage approachBiological processesRidge regressionGene expression datasetsDatasetGenomic technologiesMicroarray technologyOptimal choiceBalance efficiencyX.EstimationPrediction errorPolymerase chain reactionBiological phenomenaInformationTechnologyQuantitative real-time polymerase chain reaction
2008
Inference of the Haplotype Effect in a Matched Case-Control Study Using Unphased Genotype Data
Sinha S, Gruber S, Mukherjee B, Rennert G. Inference of the Haplotype Effect in a Matched Case-Control Study Using Unphased Genotype Data. The International Journal Of Biostatistics 2008, 4: article 6. PMID: 20231916, PMCID: PMC2835450, DOI: 10.2202/1557-4679.1079.Peer-Reviewed Original ResearchConceptsCase-control studyUnphased genotype dataHardy-Weinberg equilibriumLocus-specific genotype dataGenotype dataBeta-Carotene Cancer Prevention StudyCancer Prevention StudyCase-control study designStudy of breast cancer patientsMatched case-control studyCase-control designPhasing of haplotypesDisease risk modelsBreast cancer patientsPrevention StudyHaplotype effectsStudy designGametic phasePolymorphic lociHaplotype frequenciesCancer patientsLociConditional likelihood approachAssociationHaplotypes