2018
Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study
Wang W, Moroi S, Bakulski K, Mukherjee B, Weisskopf M, Schaumberg D, Sparrow D, Vokonas P, Hu H, Park S. Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study. Environmental Health Perspectives 2018, 126: 087002. PMID: 30102601, PMCID: PMC6108844, DOI: 10.1289/ehp3442.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaIncident primary open-angle glaucomaRisk of primary open-angle glaucomaOpen-angle glaucomaHazard ratioIncident cases of POAGCases of primary open-angle glaucomaAsymmetric cup-to-disc ratioFollow-upPrimary open-angle glaucoma casesEtiology of primary open-angle glaucomaCup-to-disc ratioVisual field defectsCox proportional hazards regressionAssociated with hazard ratiosProportional hazards regressionOxidative stressEstimate hazard ratiosDisc hemorrhageOcular evaluationPatella leadField defectsCumulative lead doseProspective cohortSurvival curves
2013
Propensity score‐based diagnostics for categorical response regression models
Boonstra P, Bondarenko I, Park S, Vokonas P, Mukherjee B. Propensity score‐based diagnostics for categorical response regression models. Statistics In Medicine 2013, 33: 455-469. PMID: 23934948, PMCID: PMC3911784, DOI: 10.1002/sim.5940.Peer-Reviewed Original ResearchConceptsRetrospective sampling designsChi-square distributionCategorical response modelsGoodness-of-fit statisticsPredicted response probabilitiesResponse regression modelsConditional distributionProportional odds modelAssess model adequacyData examplesSimulation studyVA Normative Aging StudyNormative Aging StudyPropensity scoreCumulative lead exposureOdds modelModel diagnosticsCase-control studyAssociated with diabetesBalance scoresResponse probabilityModel adequacyCohort studyAging StudyNumerical summaries
2010
Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study
Park S, Elmarsafawy S, Mukherjee B, Spiro A, Vokonas P, Nie H, Weisskopf M, Schwartz J, Hu H. Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study. Hearing Research 2010, 269: 48-55. PMID: 20638461, PMCID: PMC2934752, DOI: 10.1016/j.heares.2010.07.004.Peer-Reviewed Original ResearchConceptsAge-related hearing lossPure-tone averagePatella lead levelsCumulative lead exposureHearing lossHearing thresholdsNormative Aging StudyAssociated with poorer hearing thresholdsOdds of hearing lossAir conduction hearing thresholdsAssociated with hearing lossConduction hearing thresholdsPoorer hearing thresholdsAging StudyDevelopment of age-related hearing lossReduction of lead exposureVA Normative Aging StudyCross-sectional analysisLead exposureOccupational noiseHearing abilityK X-ray fluorescencePotential confoundersEpidemiological researchLead levelsHFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
Zhang A, Park S, Wright R, Weisskopf M, Mukherjee B, Nie H, Sparrow D, Hu H. HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study. Environmental Health Perspectives 2010, 118: 1261-1266. PMID: 20478760, PMCID: PMC2944087, DOI: 10.1289/ehp.1002251.Peer-Reviewed Original ResearchConceptsCumulative lead exposureHFE H63D polymorphismC282Y variantBone lead levelsAssociated with steeper increasesLinear mixed-effects regression modelsFamily history of hypertensionMixed-effects regression modelsDaily intake of calciumNormative Aging StudyPredictor of cardiovascular diseaseWaist circumferenceIntake of calciumHistory of hypertensionLead exposureH63D polymorphismAlcohol intakeRandom interceptFamily historyMarker of arterial stiffnessTotal caloriesAging StudySteeper increasesLead levelsCardiovascular disease
2009
Bone Lead Level Prediction Models and Their Application to Examine the Relationship of Lead Exposure and Hypertension in the Third National Health and Nutrition Examination Survey
Park S, Mukherjee B, Xia X, Sparrow D, Weisskopf M, Nie H, Hu H. Bone Lead Level Prediction Models and Their Application to Examine the Relationship of Lead Exposure and Hypertension in the Third National Health and Nutrition Examination Survey. Journal Of Occupational And Environmental Medicine 2009, 51: 1422-1436. PMID: 19952788, PMCID: PMC2939477, DOI: 10.1097/jom.0b013e3181bf6c8d.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBone and BonesBostonCohort StudiesEnvironmental ExposureFemaleHumansHypertensionLeadLongitudinal StudiesMaleMiddle AgedNutrition SurveysPatellaRadiographyRegression AnalysisRisk AssessmentRisk FactorsSpectrometry, X-Ray EmissionTibiaUnited StatesUnited States Department of Veterans AffairsYoung AdultConceptsNational Health and Nutrition Examination SurveyThird National Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyCommunity-based cohortPatella leadExamination SurveyCohort of older menCommunity-based cohort of older menK X-ray fluorescenceNHANES-IIISignificant associationBlood lead levelsOlder menStandard covariatesPatellaExternal validationCorrelation coefficientBlood leadLead exposureTibiaLead levelsAssociationSurveyLead studies