2018
Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, Wicklund K, Eder B, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. Respiratory Research 2018, 19: 228. PMID: 30463560, PMCID: PMC6249926, DOI: 10.1186/s12931-018-0922-9.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaBiomarkersChildChild, PreschoolCytokinesFemaleHumansLongitudinal StudiesLungMaleNasal LavageRespiratory Tract InfectionsVirus DiseasesConceptsViral infectionLung functionAbsence of viral infectionIL-13IL-4Viral-induced asthma exacerbationsRespiratory illnessRespiratory viral infectionsAssociated with increased cytokinesPro-inflammatory cytokinesLung function declineSelf-reported respiratory illnessInfluence of viral infectionAirway cytokinesMDA5 mRNACXCL10 mRNACytokine levelsAirway responsivenessNasal lavageAirflow obstructionAssociated with FVCAsthma exacerbationsAssociated with decreased lung functionInflammatory responseNasal samplesImpact of community respiratory viral infections in urban children with asthma
Lewis T, Metitiri E, Mentz G, Ren X, Goldsmith A, Eder B, Wicklund K, Walsh M, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M, SteeringCommittee T. Impact of community respiratory viral infections in urban children with asthma. Annals Of Allergy Asthma & Immunology 2018, 122: 175-183.e2. PMID: 30385348, PMCID: PMC6360098, DOI: 10.1016/j.anai.2018.10.021.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaBlack or African AmericanChemokine CXCL10ChildCommunity-Acquired InfectionsFemaleHumansMaleRespiratory Tract InfectionsViral LoadVirus DiseasesConceptsRespiratory viral infectionsViral infectionBiomarker elevationAirway functionSymptom scoresUpper respiratory tract viral infectionC-C motif chemokine ligand (CCL)-2Fraction of exhaled nitric oxideRespiratory tract viral infectionsRespiratory illnessUpper respiratory viral infectionReduced airway functionC-X-C motif chemokine ligandUpper respiratory tract symptomsExhaled nitric oxideMelanoma differentiation-associated protein 5Respiratory tract symptomsRespiratory tract inflammationCold-like illnessMotif chemokine ligandNormal airway functionSelf-reported respiratory illnessChemokine levelsForced expiratory flowNasal biomarkers
2012
Nasal cytokine responses to natural colds in asthmatic children
Lewis T, Henderson T, Carpenter A, Ramirez I, McHenry C, Goldsmith A, Ren X, Mentz G, Mukherjee B, Robins T, Joiner T, Mohammad L, Nguyen E, Burns M, Burke D, Hershenson M. Nasal cytokine responses to natural colds in asthmatic children. Clinical & Experimental Allergy 2012, 42: 1734-1744. PMID: 23181789, PMCID: PMC4219353, DOI: 10.1111/cea.12005.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAsthmaChemokinesChildCytokinesFemaleHumansImmunity, InnateInterferonsMaleNasal CavityRespiratory Tract InfectionsVirus DiseasesVirusesConceptsViral infectionMarker elevationSymptom scoresMarkers of viral infectionRespiratory viral infectionsRobust innate immune responsePresence of viral infectionRespiratory symptom scoresMultiplex immune assaysRespiratory tract symptomsSelf-reported respiratory illnessCCL11/eotaxin-1IFN-responsive genesInnate immune responseWeeks of assessmentNasal aspiratesCXCL10/IP-10CCL7/MCP-3IFN-gCCL2/MCP-1IRF7 mRNACXCL8/IL-8Asthma exacerbationsImmune responseMRNA signal