2017
Update on the State of the Science for Analytical Methods for Gene-Environment Interactions
Gauderman W, Mukherjee B, Aschard H, Hsu L, Lewinger J, Patel C, Witte J, Amos C, Tai C, Conti D, Torgerson D, Lee S, Chatterjee N. Update on the State of the Science for Analytical Methods for Gene-Environment Interactions. American Journal Of Epidemiology 2017, 186: 762-770. PMID: 28978192, PMCID: PMC5859988, DOI: 10.1093/aje/kwx228.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesG x EGene-environment interactionsAssociation studiesAnalysis of gene-environment interactionsQuantitative trait studiesComplex traitsGenetic dataGene setsTrait studiesGene-environmentCase-controlEnvironmental dataConsortium settingFormation of consortiaGenesConsortiumAnalytical challengesTraitsSetsStudyInteractionStatistical approachData
2014
Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting
Ko Y, Mukherjee B, Smith J, Park S, Kardia S, Allison M, Vokonas P, Chen J, Diez‐Roux A. Testing departure from additivity in Tukey's model using shrinkage: application to a longitudinal setting. Statistics In Medicine 2014, 33: 5177-5191. PMID: 25112650, PMCID: PMC4227925, DOI: 10.1002/sim.6281.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAtherosclerosisBone and BonesComputer SimulationEnvironmental ExposureEthnicityFemaleGene-Environment InteractionHumansIronLeadLeast-Squares AnalysisLikelihood FunctionsLongitudinal StudiesMaleMiddle AgedModels, GeneticUnited StatesUnited States Department of Veterans AffairsConceptsGene-environment interactionsMulti-Ethnic Study of AtherosclerosisModel of gene-environment interactionMulti-Ethnic StudyTukey's modelLongitudinal settingStudy of AtherosclerosisNormative Aging StudyCase-control studyIncreasing categoriesAging StudyTested interactionsLongitudinal studyCategorical variablesRobust to misspecificationInteraction termsTest departuresShrinkage estimatorsWald testInteraction estimatesIncreased powerOne-degree-of-freedom modelInteraction effectsSetsEnvironmental markers
2006
A Score Test for Determining Sample Size in Matched Case‐Control Studies with Categorical Exposure
Sinha S, Mukherjee B. A Score Test for Determining Sample Size in Matched Case‐Control Studies with Categorical Exposure. Biometrical Journal 2006, 48: 35-53. PMID: 16544811, DOI: 10.1002/bimj.200510200.Peer-Reviewed Original ResearchConceptsCase-control studyCategorical exposureMatched case-control studyScore testDichotomous exposureNull hypothesisExposure variablesOdds ratioNatural orderDisease-gene associationsMatched setsDisease riskColorectal cancerPower functionSample sizeAssociationOddsGeneralizationDiseaseSetsScoresEstimationExposureStudyRisk