2023
Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidenceAssociations Between Repeated Measures of Urinary Phthalate Metabolites With Hormones and Timing of Natural Menopause
Ding N, Zheutlin E, Harlow S, Randolph J, Mukherjee B, Park S. Associations Between Repeated Measures of Urinary Phthalate Metabolites With Hormones and Timing of Natural Menopause. Journal Of The Endocrine Society 2023, 7: bvad024. PMID: 36846211, PMCID: PMC9945847, DOI: 10.1210/jendso/bvad024.Peer-Reviewed Original ResearchSex hormone-binding globulinFollicle-stimulating hormoneAnti-Mullerian hormoneUrinary phthalate metabolitesTiming of natural menopausePhthalate metabolitesNatural menopauseExposure to phthalatesMeasures of urinary phthalate metabolitesAssociations of phthalate metabolitesHazard ratioAssociations of urinary phthalate metabolitesSerum concentrations of estradiolHormone-binding globulinCox proportional-hazards modelStudy of Women's HealthConcentrations of estradiolCalculate hazard ratiosProportional-hazards modelStatistically significant associationCirculating levels of testosteroneLevels of testosteroneHormone therapyOvarian reserveMidlife women
2022
Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study. Environmental Research 2022, 216: 114685. PMID: 36341787, PMCID: PMC9870605, DOI: 10.1016/j.envres.2022.114685.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBody fat gainStudy of Women's HealthBaseline obesity statusFat massFat gainObesity statusPhthalate metabolitesMidlife womenPhthalate exposureWomen's HealthX-ray absorptiometryEtiology of obesityMono-carboxy-isononyl phthalateAttenuation of estimatesBody fat percentageBody weightMono-isobutyl phthalateMono(3-carboxypropyl) phthalateNormal/underweight womenAssociated with faster increasesMenopause-related factorsStudy obesityStratified analysisFM changesAssociations between Repeated Measures of Urinary Phthalate Metabolites with Hormones and Timing of Natural Menopause: The Study of Women's Health Across the Nation
Ding N, Zheutlin E, Harlow S, Randolph J, Mukherjee B, Park S. Associations between Repeated Measures of Urinary Phthalate Metabolites with Hormones and Timing of Natural Menopause: The Study of Women's Health Across the Nation. ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-1181.Peer-Reviewed Original ResearchBiomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortMaternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomes
2021
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico
Cathey A, Eaton J, Ashrap P, Watkins D, Rosario Z, Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154: 106565. PMID: 33882432, PMCID: PMC9923976, DOI: 10.1016/j.envint.2021.106565.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionPhthalate metabolitesEnvironmental risk scoreBiomarkers of oxidative stressPregnant womenPhthalate mixtureBayesian kernel machine regression analysisEffects of phthalate metabolitesOxidative stressIndividual phthalate metabolitesLipid oxidative stressUrinary biomarker measurementsKernel machine regressionAdverse birth outcomesPuerto Rico TestsiteOxidative stress biomarkersChemical fractionationContamination threatLongitudinal birth cohortPhthalate compoundsLinear mixed effects modelsBirth outcomesOxidative stress mechanismsStudy visitsPhthalate exposure
2020
Maternal Urinary Phthalate Metabolites are Associated with Lipidomic Profiles Among Pregnant Women in Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Rosario Z, M. C, Alshawabkeh A, Cordero J, Meeker J. Maternal Urinary Phthalate Metabolites are Associated with Lipidomic Profiles Among Pregnant Women in Puerto Rico. ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-1070.Peer-Reviewed Original Research
2019
Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates
Ferguson K, Lan Z, Yu Y, Mukherjee B, McElrath T, Meeker J. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environment International 2019, 131: 104903. PMID: 31288179, PMCID: PMC6728185, DOI: 10.1016/j.envint.2019.104903.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesOxidative stress biomarkersNon-null associationsPhthalate metabolitesBiomarkers of oxidative stressInterquartile rangeBenzophenone-3Associated with increasesOutcome biomarkersIncreased maternal oxidative stressStress biomarkersExposure to environmental phenolsOxidative stressReduced fetal growthUrinary oxidative stress biomarkersMaternal oxidative stressEffect estimatesAdaptive elastic net modelStudy populationPreterm birthFetal growthConcentration of phenolUrinary phenolPregnancyUrinary concentrationsCorrigendum to “Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy” [Placenta 36 (2015) 699–703]
Ferguson K, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Corrigendum to “Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy” [Placenta 36 (2015) 699–703]. Placenta 2019, 76: 54. PMID: 30661819, PMCID: PMC6398335, DOI: 10.1016/j.placenta.2019.01.004.Peer-Reviewed Original ResearchAngiogenic biomarkersPhthalate metabolitesErratum: “Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy”
Johns L, Ferguson K, McElrath T, Mukherjee B, Meeker J. Erratum: “Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy”. Environmental Health Perspectives 2019, 127: 019003. PMID: 30620213, PMCID: PMC6371679, DOI: 10.1289/ehp4856.Peer-Reviewed Original ResearchErratum: “Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis”
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Erratum: “Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis”. Environmental Health Perspectives 2019, 127: 019001. PMID: 30620211, PMCID: PMC6371643, DOI: 10.1289/ehp4854.Peer-Reviewed Original ResearchCorrigendum to: “Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth” [Environment International 94 (2016) 531-537]
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Corrigendum to: “Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth” [Environment International 94 (2016) 531-537]. Environment International 2019, 122: 416. PMID: 30594293, DOI: 10.1016/j.envint.2018.11.062.Peer-Reviewed Original Research
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociationUrinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
Ferguson K, Meeker J, Cantonwine D, Chen Y, Mukherjee B, McElrath T. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016, 94: 531-537. PMID: 27320326, PMCID: PMC4980186, DOI: 10.1016/j.envint.2016.06.013.Peer-Reviewed Original ResearchConceptsActual fetal weightUrinary phthalate metabolitesPhthalate metabolitesFetal weightFetal growthDi-2-ethylhexyl phthalate metabolitesNon-anomalous singleton pregnanciesAssociated with decreased fetal growthConcentrations of phthalate metabolitesTime pointsExposure to di-2-ethylhexyl phthalateSingleton pregnanciesLongitudinal birth cohortFetal sexDi-2-ethylhexyl phthalateInterquartile range increaseCross-sectional associationsUltrasound scanPregnancyInverse associationMaternal exposureDelivery indexUrine samplesStandard deviation decreaseBirth cohortUrinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Cantonwine D, Meeker J, Ferguson K, Mukherjee B, Hauser R, McElrath T. Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia. Environmental Health Perspectives 2016, 124: 1651-1655. PMID: 27177253, PMCID: PMC5047771, DOI: 10.1289/ehp188.Peer-Reviewed Original ResearchRisk of preeclampsiaUrinary concentrations of BPAUrinary concentrations of bisphenol APhthalate metabolitesUrinary concentrationsAssociated with increased risk of preeclampsiaHazard ratioCases of preeclampsiaNested case-control studyDevelopment of preeclampsiaProspective birth cohort studyAssociated with increased riskPhthalate metabolite concentrationsCox proportional hazards modelsAdjusted Cox proportional hazards modelsCase-control studyAdjusted hazard ratiosCalculate hazard ratiosProportional hazards modelBirth cohort studyWeeks gestationPreterm birthAssociated with onsetPreeclampsiaUrinary BPAAssociations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Johns L, Ferguson K, McElrath T, Mukherjee B, Meeker J. Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy. Environmental Health Perspectives 2016, 124: 1808-1815. PMID: 27152641, PMCID: PMC5089879, DOI: 10.1289/ehp170.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesMaternal urinary phthalate metabolitesThyroid hormone parametersThyroid hormone levelsPregnant womenPhthalate metabolitesStudy visitsHormonal parametersNested case-control study of preterm birthMeasures of urinary phthalate metabolitesHormone levelsCase-control study of preterm birthStudy of preterm birthThyroid hormonesEnvironmental phthalate exposureNested case-control studyNormal thyroid functionLevels of thyroid hormonesThyroid function markersTime pointsCirculating levels of thyroid hormonesTotal thyroid hormonesPreterm birthFetal growthPlasma thyroid hormone levels
2015
Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy
Ferguson K, McElrath T, Mukherjee B, Loch-Caruso R, Meeker J. Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy. PLOS ONE 2015, 10: e0135601. PMID: 26317519, PMCID: PMC4552851, DOI: 10.1371/journal.pone.0135601.Peer-Reviewed Original ResearchConceptsC-reactive proteinPregnant womenPhthalate exposureInvestigate inflammationInflammation biomarkersAnalysis of pregnant womenAssociated with adverse reproductive outcomesBiomarkers of phthalate exposureUrinary phthalate metabolitesAssociated with IL-6Plasma inflammation biomarkersMono-benzyl phthalateAdverse reproductive outcomesStatistically significant associationUrinary metabolite concentrationsMaternal biomarkersPeripheral inflammationPhthalate effectsPhthalate metabolitesIL-6Reproductive outcomesInflammationMono-benzylSignificant associationTarget tissuesPhthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy
Ferguson K, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy. Placenta 2015, 36: 699-703. PMID: 25913709, PMCID: PMC4441857, DOI: 10.1016/j.placenta.2015.04.002.Peer-Reviewed Original ResearchConceptsSFlt-1 to PlGF ratioSFlt-1Biomarkers of angiogenesisPhthalate metabolitesPlGF ratioPlacental developmentSoluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Tyrosine kinase-1Placental growth factorUrinary DEHP metabolitesProspective birth cohortAdverse birth outcomesCase-control populationDelivered pretermGestational ageAngiogenic biomarkersExposure to phthalatesUrinary biomarkersDEHP metabolitesBirth outcomesPlasma biomarkersPregnancyPlGFAssociated with decreasesStatistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth
Chen Y, Ferguson K, Meeker J, McElrath T, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015, 14: 9. PMID: 25619201, PMCID: PMC4417225, DOI: 10.1186/1476-069x-14-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersBostonCase-Control StudiesCross-Sectional StudiesData Interpretation, StatisticalEnvironmental ExposureFemaleHazardous SubstancesHumansInfant, NewbornMaternal ExposureMiddle AgedModels, StatisticalPhthalic AcidsPregnancyPremature BirthSocioeconomic FactorsYoung AdultConceptsPreterm birthEnvironmental chemical exposuresMeasures of urinary phthalate metabolitesNested case-control studyCross-sectional analysisAverage exposureMeasures of exposureCase-control studyUrinary phthalate metabolitesModel repeated measuresEpidemiological research projectsLongitudinal exposureRepeated measuresPremature birthPretermEnvironmental exposure biomarkersExposure measurementsUrinary metabolitesMaternal factorsPhthalate metabolitesPregnancyStudy of phthalatesLongitudinal predictorsChemical exposureBirth